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Protein Overview: HRR25

General Information:
Name(s) found: HRR25 / YPL204W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 494 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    nucleus [IDALink to PubMed article]
    Biological Process: mitosis [IMPLink to PubMed article]
    meiosis [IMPLink to PubMed article]
    chromosome segregation [TASLink to PubMed article]
    DNA repair [IMPLink to PubMed articleLink to PubMed article]
    nuclear division [TASLink to PubMed article]
    ribosomal small subunit biogenesis [IMPLink to PubMed article]
    Molecular Function: casein kinase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [NCBI BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLRVGRKFR IGRKIGSGSF GDIYHGTNLI SGEEVAIKLE SIRSRHPQLD YESRVYRYLS  60
   61 GGVGIPFIRW FGREGEYNAM VIDLLGPSLE DLFNYCHRRF SFKTVIMLAL QMFCRIQYIH 120
  121 GRSFIHRDIK PDNFLMGVGR RGSTVHVIDF GLSKKYRDFN THRHIPYREN KSLTGTARYA 180
  181 SVNTHLGIEQ SRRDDLESLG YVLIYFCKGS LPWQGLKATT KKQKYDRIME KKLNVSVETL 240
  241 CSGLPLEFQE YMAYCKNLKF DEKPDYLFLA RLFKDLSIKL EYHNDHLFDW TMLRYTKAMV 300
  301 EKQRDLLIEK GDLNANSNAA SASNSTDNKS ETFNKIKLLA MKKFPTHFHY YKNEDKHNPS 360
  361 PEEIKQQTIL NNNAASSLPE ELLNALDKGM ENLRQQQPQQ QVQSSQPQPQ PQQLQQQPNG 420
  421 QRPNYYPEPL LQQQQRDSQE QQQQVPMATT RATQYPPQIN SNNFNTNQAS VPPQMRSNPQ 480
  481 QPPQDKPAGQ SIWL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) Manuscript in preparation. DIM1 ENP1 HRR25 LTV1 RIO2 TSR1
    View Details (MIPS) Mewes HW, et al. (2004) HRR25 YCK1 YCK2 YCK3
    View Details Gavin AC, et al. (2006) HRR25 LTV1 NOB1 RIO2 TSR1
    View Details Gavin AC, et al. (2002) ADH1 ARP9 ATG26 BEM2 BUD3 CBF5 COP1 CYR1 DIM1 ECM16 EMG1 ENP1 HRR25 IMG1 IMG2 IML1 IMP3 IMP4 KRE33 KRR1 LTV1 MHR1 MPP10 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 NOB1 NOC4 NOP1 NOP14 NUG1 PAA1 PFK1 PNO1 PRP43 PTC3 RAD50 RCL1 RET2 RIO2 ROM2 RRP12 RTC6 SAM1 SEC1 SEC26 SEC27 SIN4 SLX9 SNF12 SNF2 SNF5 SNF6 SOF1 SWI1 SWI3 SWP82 SYP1 TAF5 TSR1 UTP15 UTP20 UTP22 UTP6 UTP7 VPS1 VPS15 YDR115W YGR054W YML6
    View Details Ho Y, et al. (2002) ABP1 ACO1 AIM41 ARP4 ATE1 ATP4 BUD14 CAR2 CDC25 CDC33 CKA2 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 EAF1 EDC3 EDE1 EGD2 ENP1 EPL1 ESA1 FPR3 GAS1 GCN3 GLC7 GPH1 HHF2, HHF1 HRR25 HSP104 HXT7 HYP2 IPP1 LOC1 LSP1 LTV1 MDH1 MDS3 MGE1 NSA1 NUG1 OYE2 PEX19 PIL1 PIN4 POR1 PTC4 PUF3 RIO2 RPC19 RPM2 SAP185 SAP190 SAS10 SEC2 SEC23 SES1 SFB3 SGM1 SIT4 TAF14 TAF4 TGL1 TIP41 TMA19 TRA1 TSR1 TUF1 VMA4 YBR225W YER138C YRA1
    View Details Qiu et al. (2008) HRR25 YCK1 YCK2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HRR25 Huh WK, et al. (2003)
    [View in YRC Public Image Repository] (1 experiment(s)and 3 images)

    Protein Structure Data


    [What does the above image mean?] [View Top Sequence Alignments]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..52]
    [68..84]    		 PSI-BLAST 1370.0 Casein kinase-1, CK1
    2 View Details [53..67]
    [85..347]    		 PSI-BLAST 1370.0 Casein kinase-1, CK1
    3 View Details [348..494] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.54265774272269 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.16831387024372 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • growth factor binding
    		•  0.86076618871384 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.835012681606991 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.835012681606991 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.832111648073981 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.794058505655489 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.775404673285876 bayes_pls_golite062009
  • DNA binding
    		•  0.714163549867672 bayes_pls_golite062009
  • ligase activity
    		•  0.665445021164512 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transcription factor activity
    		•  0.563262875317016 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.451090007290896 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • telethonin binding
    		•  0.366817170817532 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.26024936404169 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.20643152368029 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.20643152368029 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.205652638854091 bayes_pls_golite062009
  • RNA binding
    		•  0.202560498527088 bayes_pls_golite062009
  • receptor binding
    		•  0.197402253061255 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.0795689006739899 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by:     Michael Riffle