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Protein Overview: RET2

General Information:
Name(s) found: RET2 / YFR051C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 546 amino acids

    Gene Ontology:
    Cellular Component: COPI vesicle coat [IMPLink to PubMed article][ISSLink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IMPLink to PubMed article]
    retrograde vesicle-mediated transport, Golgi to ER [IMPLink to PubMed article]
    Molecular Function: protein binding [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVLAASITT RQGKPLLSRQ FKDLSKDRVL ELLSNFQNLV SEISSDHTFV EDKHVRYVYR  60
   61 PFDNYYIILI TNRQSNIIKD LATLNLFSQT INSYLSSFQD QEIFHNAFEI LSSFDEIVSM 120
  121 GGYKENLSFT QVQTYLSMES HEERIQEIIE RNKEIEATEE RKRRAKEIAR KEHERKHGFM 180
  181 SSNGDYDGAN RFMGSKDPNV TNAINSYYSH ASPAAQQSYL QSSHAAAAEV APVASPMATS 240
  241 QRAGHSATGG MKLGGGAGRR AGAAPRPSAI SSASSGTPPP PEEDVPENNG ILISIKEVIN 300
  301 AEFSRDGTIH SSELKGVLEL RINDHDLSHS NLKLADSIDV RDKSFQFKTH PNIDKQSFLS 360
  361 TKLISLRDKS KAFPANDQSL GVLRWRKVAP AEDDSLIPLT LTTWVSPSES QQGFDVIIEY 420
  421 ESVLETELAD VIFTIPVFPQ EPVDINTESS TCSDAEVVNM DQEMGTSIKI SKIAANDAGA 480
  481 LAFTIEAPYE DALYPMTVSF QESTRDKLAK SFTGMAIQSV VMANDHDQEL PYDVITSLKS 540
  541 DEYLVQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) COP1 RET2 RET3 SEC21 SEC26 SEC27 SEC28
    View Details (MIPS) Mewes HW, et al. (2004) ARF1 COP1 RET2 RET3 SEC21 SEC26 SEC27 SEC28
    View Details Krogan NJ, et al. (2006) COP1 FCF2 FMP23 LCB5 PIP2 RET2 RET3 SCS2 SEC2 SEC21 SEC26 SEC27 SEC28
    View Details Gavin AC, et al. (2006) COP1 RET2 RET3 SEC21 SEC26 SEC27 SEC28
    View Details Gavin AC, et al. (2002) ATG26 BEM2 BUD3 COP1 CYR1 GLO3 GPT2 HRR25 ILV1 IMG1 IMG2 IML1 MHR1 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 NUG1 PGK1 PRP43 RET2 RET3 ROM2 RTC6 SAM1 SCJ1 SEC1 SEC21 SEC26 SEC27 SEC28 SEH1 SIN4 SNF2 SWI3 SYP1 TAF5 TOS1 UTP20 YDR115W YML6
    View Details Ho Y, et al. (2002) ADR1 ARG4 ATP3 AYR1 COP1 COR1 CPR6 ERG27 GPT2 LIA1 MAE1 OM45 PCT1 PDA1 PET10 PET9 PHO86 PIL1 PRB1 PRE10 PRO3 RET2 RNR2 RTN2 RVS161 SEC18 SEC21 SEC26 SEC27 SEC28 TIF34 TIF35 TPA1 TRP3 YNL181W
    View Details Qiu et al. (2008) ARF1 COP1 GDA1 GLO3 RET2 RET3 SEC21 SEC24 SEC26 SEC27 SEC28

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RET2 and COP1 Huh WK, et al. (2003)
    View Data RET2 Huh WK, et al. (2003)
    View Data RET2 and ANP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] PSI-BLAST 101.274545 Sigma2 adaptin (clathrin coat assembly protein AP17)
    2 View Details [86..177] PSI-BLAST 101.274545 Sigma2 adaptin (clathrin coat assembly protein AP17)
    3 View Details [178..233] deduced N/A No confident structure predictions are available.
    4 View Details [234..546] PSI-BLAST 77.522879 Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; Mu2 adaptin (clathrin coat assembly protein AP50)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle