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Protein Overview: IML1

General Information:
Name(s) found: IML1 / YJR138W [SGD]
Description(s) found:
Found 27 descriptions.
SHOW ALL
  • Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1584 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFAKLHGKKQ RPISSINSQT PRTSNTTHAN SISLSSGNLI VGSNRNLRQK KEQFGSQQRA  60
   61 SGRKLISNKE NDDNVNNGGD NNYDNGERVH RHHIPGLKIK AYQAELGYHE SRFSENLVML 120
  121 NLVEFPDIKP GDLVELKTYH KNPSASNGDK KIYFIAKDFD GETKRRAKTS NVSILSGQLQ 180
  181 TLLDLPSRSR IWIKLKPNKF DLQADVVEFN IKDCLLNRGD MWVLSSKLVD TCVFMDQRLA 240
  241 FLDSIRGTIK GIYRNGKKIV SGYIGEQTRI IFRSESARLI FLIQITDEMW NFEETGEQLF 300
  301 QKMVNSFFPK IFKKWKDVDT HHTITIAFAI SMDLSDTSFK DLTPGESLKN SQDYFRIVVD 360
  361 QVSIIHWVDI METLREEFME IRKDLLNKQT DKGYSVANGR FSPVIKSNFL ELVNFATTIL 420
  421 TDPFKQLDLR HTTTHVMIIS PGSGLFDVDY SLLRLTGKKL LSLEMTMDLI CLSKAPLHIV 480
  481 PLFRYRDFEN KLHHCVPLWL SVFFWNDHDK KSNSEWTPRC KIYDLQMMGI TENELIREVD 540
  541 VEYLQLNKKV KSLSEFMNDY DKNAFEVKIL CAGSNTKQSK KLNSKFDTVF ENDVVVKARK 600
  601 IPATATTTHG NTKFIWRGPK VALPAIKDIQ KPNVIPDLSI KTIEASFYDD CNTTNDKIST 660
  661 PTTSNNDNLE MNDSLVSVRS ADNQNTSLAL DSLKGLSKRN SLKDFTQRVI TKFISNIDTS 720
  721 KNKKIKSTLL RDDVDNSPLG SNTPLPSSES KISGLKLQQK GLADENVISK RGNLIIKKNL 780
  781 SIFGLPSNEI MSGSPSSYLG SSHTRTSSKL SNMSDKAAFI TEGQKSKHDD SNTYSLTQQL 840
  841 KHRISETWVD IKSPSIPVSS EFANELLPIR WKDVWPKYVA RKYSKWRSFT TPAELPITIS 900
  901 DFPSKDDFDR NFIFRNHSVT LNTDQEQYNQ TYKDLLRDMI YMRLLTGFQI CVGRQVEKIE 960
  961 LSRESGESET VVNKYLDFNQ NDAFKLYLMI DSEIHRITCS SSGIIDVERY LRKDEANLFD1020
 1021 QVPSYIPLVK TRYESSFRDA MIDPLHVKRE SLNWNQIDQV LAGYGDNLID RKWHGFRAKY1080
 1081 VVLPTDIPPN TYSMVINGKS ETLNPEEIRV EGLRRLIGSI TRSRLRTEKE KKGRKTKREE1140
 1141 IQPEVMFYTG PLYNFINEQQ TSLESSAINF KDSIFVNDNN LLNRNVELSK LAYQIQRGED1200
 1201 RITLVNRKWH WKKHEKCFVG SEMVNWLIRN FSDIDTREDA IKYGQKVMKE GLFVHVLNKH1260
 1261 NFLDGHYFYQ FSPEYVMDTN KLEKTNSHRS TLSDPKQMLR KASTGSSNDP SAMTPFSSVV1320
 1321 PAISASNASV ADAKEPSRPI LMLSNSLVID VDPAGKSSKQ ESCTVHYDRV HNPDHCFHIR1380
 1381 LEWLTTTPKL IDDLVGNWSR LCERYGLKMI EIPWEELCTI PSVNPFHSFV EIKLAINPWE1440
 1441 DPEFKDRELF AKSKFYYHVY LLKASGFLLD NRASKFLQNQ DIEFDIMYSW GKPQFKYVQY1500
 1501 IHHTGAYVAE LRENGCLFLA PNNIYISRVN PGNIIGKIHS ASSSSLDAQK VILNFKSTCL1560
 1561 DYQKLRSIFL DAKEMWITGK IVED

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) CDC55 COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8 ECM5 IML1 PSD2
    View Details Gavin AC, et al. (2002) ACE2 ALT2 ATG26 BCK1 BDF2 BEM2 BLM10 BUD3 CDC11 CDC55 CDC73 CIN1 CKA1 CKA2 CKB1 CKB2 COP1 CTR3 CTR9 CYR1 DAL3 DRE2 DYN1 ECM30 ECM5 ENP2 ERG13 GLN1 GLY1 GTO3 GUS1 HAT1 HAT2 HCA4 HHF1, HHF2 HIF1 HOS2 HOS4 HRR25 HSM3 ICL1 IMG1 IMG2 IML1 KAP123 KAP95 KEL1 KRE33 LEO1 LHP1 LIP2 LTE1 LYS12 MAC1 MCM2 MDN1 MHR1 MIS1 MKS1 MNL1 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 MSB1 MTR4 MYO2 MYO5 NAB3 NAB6 NAM7 NIP1 NMD5 NPL3 NRD1 NRP1 NUG1 PAF1 PFK1 POB3 POL2 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PRO1 PRP43 PRT1 PSD2 PSE1 PSH1 PUB1 PUP1 PUP2 PUP3 REG1 RET2 RGC1 ROM2 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RRD2 RSC3 RTC6 RTF1 RTS1 RTS3 SAM1 SCL1 SEC1 SEC26 SEC27 SEC3 SET3 SGN1 SIF2 SIN4 SMD3 SNF2 SNT1 SPT16 SRP1 STO1 SWI1 SWI3 SYP1 TAF5 TDH2 TDH3 TEF4 TEL1 TIF1, TIF2 TIF4631 TIF4632 TPD3 TPS1 TPS2 TPS3 TSC10 TSC11 TSL1 UBP15 USO1 UTP20 VTH2 YBL044W YBL104C YDR115W YFR006W YIL177C YJR098C YML6 YNL313C YOR1 YPR077C YRA1 ZDS1 ZDS2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen IML1 RFC2 2 Unpublished Fields Lab Data
    View Screen IML1 YKL115C 2 Unpublished Fields Lab Data
    View Screen IML1 ENT4 2 Unpublished Fields Lab Data
    View Screen IML1 GIS3 2 Unpublished Fields Lab Data
    View Screen IML1 CBS2 2 Unpublished Fields Lab Data
    View Screen IML1 HAC1 2 Unpublished Fields Lab Data
    View Screen IML1 VPS45 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data IML1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [114..573] MSA 2.003826 View MSA. No confident structure predictions are available.
    3 View Details [574..852] deduced N/A No confident structure predictions are available.
    4 View Details [853..953] MSA 1.005979 View MSA. No confident structure predictions are available.
    5 View Details [954..1170] deduced N/A No confident structure predictions are available.
    6 View Details [1171..1304] PSI-BLAST 50.70927 Segment polarity protein Dishevelled-1
    7 View Details [1305..1584] deduced N/A No confident structure predictions are available.
    8 View Details [960..1151] deduced N/A No confident structure predictions are available.
    9 View Details [1152..1274] PSI-BLAST 27.0 Regulatory domain of epac2, domain 2; Regulatory domain of Epac2, domains 1 and 3
    10 View Details [1275..1337] deduced N/A No confident structure predictions are available.
    11 View Details [1338..1480] deduced N/A No confident structure predictions are available.
    12 View Details [1481..1584] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9
    Term Confidence Notes
  • binding
    		•  1.72090787140675 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.59132356860747 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.5215255296187 bayes_pls_golite062009
  • DNA binding
    		•  1.50188209285697 bayes_pls_golite062009
  • transcription factor activity
    		•  0.761675280117783 bayes_pls_golite062009
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle