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Protein Overview: BLM10

General Information:
Name(s) found: BLM10 / YFL007W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2143 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    proteasome core complex [IDALink to PubMed article][IMPLink to PubMed article]
    proteasome complex [IDALink to PubMed article]
    Biological Process: protein catabolic process [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    proteasome assembly [IMPLink to PubMed article]
    Molecular Function: proteasome activator activity [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTANNDDDIK SPIPITNKTL SQLKRFERSP GRPSSSQGEI KRKKSRLYAA DGRPHSPLRA  60
   61 RSATPTLQDQ KLFNGMDSTS LLNERLQHYT LDYVSDRAQH MKNIYDPSSR WFSRSVRPEF 120
  121 PIEEFLPYKT ESHEDQAKYL CHVLVNLYIA ISSLDIQGLI SISSKDLADL KKEVDDLALK 180
  181 TDLFRLSNNT AENDLLGNDI ADYDDAEGLE DELDEYFDLA GPDFNATGKI TAKSATIVNV 240
  241 NHWTNELKNC LHFDFPVALR KSLATVYYYL SLVQGQKVYR QMHVDMFERL VSLDDDRTNF 300
  301 TELLQKQGLL LDHQIMLNFL CEFLPYPDPD YARYELSSKE DLQLFRLLLK HAHNAKPFFD 360
  361 KSKESLLVDT MNFLLSSLAP STMMAVMPIV TSVVPYHYHI HSKIIDYFPF CYSIWSSVSA 420
  421 NVAIDTHMYD FVGSISKDVH NKILSSEHEK DVVGVEFGEF GIFTDDQMTF MFNRLQGHLR 480
  481 TDGQIHSYSR TVKPFVYAIN GSKKDRFFEK LVSLAKAIET FIHPSNNGFW TKPNAKFVHA 540
  541 FIKSYHGRVK YEEDICARGV TNGICLTSFC HEEIVEIFLN IISLGSQNKN PDIANYYISC 600
  601 FAYLLELDPS NAYLIYDKIL IDLYDTLADQ FINSRHRIIS SLKQFTRVIR FIVMDKLYRV 660
  661 HITNVLSMLV SKLDMNDTNL TSNLINGIVS IAAFIPIQDL TGEDDYISFE SDTLPLVQQH 720
  721 FYHIKCGESS KTFRVDDELL NNAFKASTTV FQSMLKVYVE KIFQLVDVDL EDSLVTKINQ 780
  781 TTMILQESMD DKIFNYFASL LQRNFWSNDS FKEKDPNYEL VTIPLAALVR RNNGLSKELV 840
  841 RTLLFHIKEQ IKRGAGSVRS TSEIQQRDVK LVLYLTALND VLRQCHESLL EYSDELITFM 900
  901 KYLYDNVTNP PLDVITSIVI HSALATLCTT EITDCRLFPE DSKIPEKDRW GGLQFDPRRF 960
  961 DKQHLSFQWH VPSSDEITLS ISILESLSEY CINNVEELMK APRHDSEYGD MIQKYVLVMT1020
 1021 HTLSGSSLLF DPDFNKYRTQ SNLSYREKLI LLKNIRENNC DPQELDIDIE QIRSGKDDED1080
 1081 YIESKDIEAG LNAGVSDVVQ LRDEFPDELI VDEEVVSEMP SGVNTPIAGT HGTDNSAMSS1140
 1141 DLAFRDLDIY TCNYYFGNTT EEKLQNPQYL QVHRVRARIG HFFHKLYVFL STNFENNTNM1200
 1201 FQILLHGLKV WFTDLGQETV FNEDPNAFID VDFLENVQSL SHVNEPFTRT NFAIRANSLH1260
 1261 QSRVLLHSTN RKASKLENLL LVDIIQLATS LYPDIYKPAQ GTLVHCMKQL VGSYGVVINK1320
 1321 IIPSLEKAIK DHDYMKIQVI LNVLLIKKIH RKLMTDYKDI GRLIFLLIEC CRVNELEIGM1380
 1381 YADKILTDIV IGIKIPSSVC VISDQAFLPL APPDGTINLQ VEAVKLAKKK KREYYLSLLV1440
 1441 DLQDKLLDKL DNEKDMGWKI RMFILRFVTQ IQSNLESKPD KRAVFSIISQ ISTKHPEIIH1500
 1501 LVVKSLLSTC NKIISLSDYE YDITRAYKNE FNPSFVEILD TSTTSFPKTF TEEMNNFDNP1560
 1561 KYFIDLRAYV GWLCWGRLMY VMSPKALKLN LRENELEVLK TAGHLLTREF LRDVTMNLVQ1620
 1621 DNETRGVFSS GNVSFFSLVI LLISSGFCEL NMSDLFELCE SYYNKDDKAS MIMSVEIVAG1680
 1681 LVCGSKFMSV SDLDKRDTFI ENFLAKCLDY ELNHDAFEIW STLAWWLPAV VDLRRSKTFF1740
 1741 CHFINADGMF DRESDAATHQ TSKIYMLRSI LMSMEFRAPD VGKLFDELVF DHPYDQVRQA1800
 1801 VAKLLTTLVQ NQSNPSISDP TTLLEAERND PDGLGLPLKS VPEKVDAYIK KQFEIIKNLE1860
 1861 DSVVGLNPQQ FIKTDYFYRT STIFYWIKEM ARGPNKVLLV PYLVDYVLPF LIGLVKHKDV1920
 1921 CALASLDPVR LYAGLGYMPI RKNHVAAIVD YVCSSNVALS SNQTKLQLAF IQHFLSAELL1980
 1981 QLTEEEKNKI LEFVVSNLYN EQFVEVRVRA ASILSDIVHN WKEEQPLLSL IERFAKGLDV2040
 2041 NKYTSKERQK LSKTDIKIHG NVLGLGAIIS AFPYVFPLPP WIPKQLSNLS SWARTSGMTG2100
 2101 QAAKNTISEF KKVRADTWKF DRASFNTEEL EDLEGVLWRS YYA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BLM10 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 SCL1
    View Details Gavin AC, et al. (2002) BLM10 CDC55 CDC6 CIN1 DAM1 DBP9 ECM29 ERG13 EST3 GFA1 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 INO4 KAP95 KEL1 LTE1 LYS12 MDS3 MLH2 MYO5 NUD1 PDA1 PDB1 PFK1 PGK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PSE1 PUP1 PUP2 PUP3 RGR1 RPN10 RPN11 RPN12 RPN13 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRD2 RRP12 RTS1 RTS3 SCL1 SET3 SIF2 SLX9 SNT1 SPA2 SRP1 TDH2 TDH3 TEF4 TPD3 UBP6 ULP1 YBL104C YFL006W YMR310C YOR1 YRA1 ZDS1 ZDS2
    View Details Ho Y, et al. (2002) BLM10 SEC53 SIR2 SIR3 SIR4 SRP1 YFL006W
    View Details Qiu et al. (2008) BLM10 PRE10 UMP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BLM10 Huh WK, et al. (2003)
    View Data BLM10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..230] deduced N/A No confident structure predictions are available.
    2 View Details [231..300] deduced N/A No confident structure predictions are available.
    3 View Details [301..377] deduced N/A No confident structure predictions are available.
    4 View Details [378..449] deduced N/A No confident structure predictions are available.
    5 View Details [450..554] deduced N/A No confident structure predictions are available.
    6 View Details [555..707] deduced N/A No confident structure predictions are available.
    7 View Details [708..856] deduced N/A No confident structure predictions are available.
    8 View Details [857..1034] deduced N/A No confident structure predictions are available.
    9 View Details [1035..1165] deduced N/A No confident structure predictions are available.
    10 View Details [1166..1328] deduced N/A No confident structure predictions are available.
    11 View Details [1329..1412] deduced N/A No confident structure predictions are available.
    12 View Details [1413..1588] deduced N/A No confident structure predictions are available.
    13 View Details [1589..1813] deduced N/A No confident structure predictions are available.
    14 View Details [1814..1982] deduced N/A No confident structure predictions are available.
    15 View Details [1983..2143] MSA 3.023948 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10
    Term Confidence Notes
  • binding
    		•  2.96084803796407 bayes_pls_golite062009
  • hydrolase activity
    		•  2.62777210765927 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.2915564382469 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.78626120336243 bayes_pls_golite062009
  • DNA binding
    		•  1.62962293446832 bayes_pls_golite062009
  • protein binding
    		•  1.61131270705552 bayes_pls_golite062009
  • transcription factor activity
    		•  0.931585995872658 bayes_pls_golite062009
  • structural molecule activity
    		•  0.907636867485115 bayes_pls_golite062009
  • translation regulator activity
    		•  0.845133720454593 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.825554268911902 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.594620724124658 bayes_pls_golite062009
  • mRNA binding
    		•  0.328122666854777 bayes_pls_golite062009
  • RNA binding
    		•  0.243875756041061 bayes_pls_golite062009
  • transcription activator activity
    		•  0.005251231402011 bayes_pls_golite062009
    11 No functions predicted.
    12 No functions predicted.
    13 No functions predicted.
    14 No functions predicted.
    15 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.57

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle