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Protein Overview: PRE3

General Information:
Name(s) found: PRE3 / YJL001W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 215 amino acids

    Gene Ontology:
    Cellular Component: proteasome core complex, beta-subunit complex [IPILink to PubMed article][TASLink to PubMed article]
    Biological Process: ascospore formation [TASLink to PubMed article]
    response to stress [TASLink to PubMed article]
    ubiquitin-dependent protein catabolic process [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: endopeptidase activity [TASLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGIQVDINR LKKGEVSLGT SIMAVTFKDG VILGADSRTT TGAYIANRVT DKLTRVHDKI  60
   61 WCCRSGSAAD TQAIADIVQY HLELYTSQYG TPSTETAASV FKELCYENKD NLTAGIIVAG 120
  121 YDDKNKGEVY TIPLGGSVHK LPYAIAGSGS TFIYGYCDKN FRENMSKEET VDFIKHSLSQ 180
  181 AIKWDGSSGG VIRMVVLTAA GVERLIFYPD EYEQL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BLM10 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 SCL1 URH1 YCR076C
    View Details (MIPS) Mewes HW, et al. (2004) PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 SCL1 UMP1
    View Details Krogan NJ, et al. (2006) ACK1 CIN8 DCG1 GNA1 MCM6 MLP1 PMD1 PMT4 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RFT1 SCL1 SGA1 SNQ2 TOS8 UMP1 YCR076C YDR179W-A YJL132W YKR070W YLR211C YLR290C
    View Details Gavin AC, et al. (2006) PRE10 PRE2 PRE3 PRE6 PRE8 PUP3 SCL1
    View Details Gavin AC, et al. (2002) BLM10 CDC6 DAM1 DBP9 ECM29 EST3 GFA1 INO4 KAP95 LYS12 MDS3 MLH2 NAS6 NUD1 PDA1 PDB1 PGK1 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PSE1 PUP3 RGR1 RPN10 RPN11 RPN12 RPN13 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRP12 SCL1 SLX9 SPA2 SRP1 UBP6 ULP1 YFL006W YMR310C YRA1
    View Details Ho Y, et al. (2002) ADD66 BUD7 COR1 GAL7 PBA1 PRE1 PRE10 PRE2 PRE3 PRE5 PRE6 PRE7 PRE8 PRE9 PUP2 PUP3 QCR2 SCL1 SLT2 SMK1 STI1 YHR033W
    View Details Qiu et al. (2008) PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RPN10 RPN11 RPN12 RPN13 RPT1 RPT2 RPT3 RPT4 RPT6 SCL1 UMP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TID3 No Comments Cheeseman IM, et al. (2002)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PRE3 PUP1 2 Unpublished Fields Lab Data
    View Screen PRE3 AOS1 2 Unpublished Fields Lab Data
    View Screen PRE2 PRE3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRE3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 1202.39794 Proteasome beta subunit (catalytic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endopeptidase activity
    		•  6.91642761177919 bayes_pls_golite062009
  • peptidase activity
    		•  6.84511694091156 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.5973571808298 bayes_pls_golite062009
  • hydrolase activity
    		•  4.47652590304822 bayes_pls_golite062009
  • threonine-type endopeptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • threonine-type peptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009
  • binding
    		•  1.18139971903068 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.448212653390607 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle