YRC Public Data Repository - Protein Structure Prediction

Protein:	PRE3
Organism:	Saccharomyces cerevisiae
Length:	215 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRE3.

Description	E-value	Query Range	Subject Range
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1 PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1	3.0E-66	[2..214]	[20..232]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ... PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1	4.0E-65	[2..214]	[20..232]
PSA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=p... PSMA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus GN=psmA PE=3 SV=1	2.0E-64	[2..214]	[20..232]
PSA_THEK1 - Proteasome subunit alpha OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=psmA PE=3 SV=1 PSA_THEK1, PSMA_... - Proteasome subunit alpha OS=Thermococcus sp. (strain KS-1) GN=psmA PE=3 SV=1, Proteasome subunit alp... gi\|11265988 - pir\|\|T43887 proteasome alpha chain [imported] - Thermococcus sp	6.0E-62	[2..214]	[20..232]
PSB5_SPIOL - Proteasome subunit beta type-5 OS=Spinacia oleracea PE=2 SV=1	8.0E-62	[2..215]	[40..250]
gi\|18157533 - gi\|18157533\|dbj\|BAB83848.1\| PSMB8-A [Oryzias latipes]	1.0E-61	[8..215]	[60..266]
gi\|286250 - gi\|286250\|dbj\|BAA01587.1\| proteasome subunit R-IOTA [Rattus sp.] gi\|67969980 - gi\|67969980\|dbj\|BAE01337.1\| unnamed protein product [Macaca fascicularis] PSMA6 - proteasome (prosome, macropain) subunit, alpha type, 6 PSA6_BOVIN - Proteasome subunit alpha type-6 OS=Bos taurus GN=PSMA6 PE=1 SV=1 gi\|55640605, gi\|... - gi\|55640605\|ref\|XP_509906.1\| PREDICTED: proteasome alpha 6 subunit isoform 6 [Pan troglodytes], gi\|1... gi\|109083327, gi... - gi\|109083327\|ref\|XP_001086524.1\| PREDICTED: similar to Proteasome subunit alpha type 6 (Proteasome i... gi\|149692835 - gi\|149692835\|ref\|XP_001491320.1\| PREDICTED: similar to proteasome alpha 6 subunit [Equus caballus] ENSOCUP000000134... - pep:novel chromosome:oryCun2:17:55028440:55047757:1 gene:ENSOCUG00000015635 transcript:ENSOCUT000000... PSA6_RAT - Proteasome subunit alpha type-6 OS=Rattus norvegicus GN=Psma6 PE=1 SV=1 gi\|123983062 - gi\|123983062\|gb\|ABM83272.1\| proteasome (prosome, macropain) subunit, alpha type, 6 [synthetic constr... gi\|222154129 - gi\|222154129\|gb\|ACM47241.1\| proteasome subunit alpha type 6 [Capra hircus] tr\|M3WV20\|M3WV20... - Proteasome subunit alpha type OS=Felis catus GN=PSMA6 PE=3 SV=1	4.0E-61	[3..214]	[20..237]
gi\|1405323 - gi\|1405323\|dbj\|BAA10932.1\| LMPX of lamprey [Petromyzon marinus]	1.0E-60	[12..215]	[63..265]
gi\|6984140 - gi\|6984140\|gb\|AAF34770.1\|AF227625_1 proteasome 27 kDa subunit [Euphorbia esula]	1.0E-60	[3..215]	[8..228]

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Predicted Domain #1

Region A:
Residues: [1-215]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGIQVDINR LKKGEVSLGT SIMAVTFKDG VILGADSRTT TGAYIANRVT DKLTRVHDKI  60
   61 WCCRSGSAAD TQAIADIVQY HLELYTSQYG TPSTETAASV FKELCYENKD NLTAGIIVAG 120
  121 YDDKNKGEVY TIPLGGSVHK LPYAIAGSGS TFIYGYCDKN FRENMSKEET VDFIKHSLSQ 180
  181 AIKWDGSSGG VIRMVVLTAA GVERLIFYPD EYEQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1202.39794
Match:	1rypH_
Description:	Proteasome beta subunit (catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009
binding	1.18139971903068	bayes_pls_golite062009
nucleic acid binding	0.448212653390607	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: