Protein Overview: SNQ2

General Information:
Name(s) found:	SNQ2 / YDR011W [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species [SGD]
Organism:	Saccharomyces cerevisiae
Length:	1501 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ] plasma membrane [IDA]
Biological Process:	response to drug [TAS] response to singlet oxygen [IMP]
Molecular Function:	xenobiotic-transporting ATPase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNIKSTQDS SHNAVARSSS ASFAASEESF TGITHDKDEQ SDTPADKLTK MLTGPARDTA  60
   61 SQISATVSEM APDVVSKVES FADALSRHTT RSGAFNMDSD SDDGFDAHAI FESFVRDADE 120
  121 QGIHIRKAGV TIEDVSAKGV DASALEGATF GNILCLPLTI FKGIKAKRHQ KMRQIISNVN 180
  181 ALAEAGEMIL VLGRPGAGCS SFLKVTAGEI DQFAGGVSGE VAYDGIPQEE MMKRYKADVI 240
  241 YNGELDVHFP YLTVKQTLDF AIACKTPALR VNNVSKKEYI ASRRDLYATI FGLRHTYNTK 300
  301 VGNDFVRGVS GGERKRVSIA EALAAKGSIY CWDNATRGLD ASTALEYAKA IRIMTNLLKS 360
  361 TAFVTIYQAS ENIYETFDKV TVLYSGKQIY FGLIHEAKPY FAKMGYLCPP RQATAEFLTA 420
  421 LTDPNGFHLI KPGYENKVPR TAEEFETYWL NSPEFAQMKK DIAAYKEKVN TEKTKEVYDE 480
  481 SMAQEKSKYT RKKSYYTVSY WEQVKLCTQR GFQRIYGNKS YTVINVCSAI IQSFITGSLF 540
  541 YNTPSSTSGA FSRGGVLYFA LLYYSLMGLA NISFEHRPIL QKHKGYSLYH PSAEAIGSTL 600
  601 ASFPFRMIGL TCFFIILFFL SGLHRTAGSF FTIYLFLTMC SEAINGLFEM VSSVCDTLSQ 660
  661 ANSISGILMM SISMYSTYMI QLPSMHPWFK WISYVLPIRY AFESMLNAEF HGRHMDCANT 720
  721 LVPSGGDYDN LSDDYKVCAF VGSKPGQSYV LGDDYLKNQF QYVYKHTWRN FGILWCFLLG 780
  781 YVVLKVIFTE YKRPVKGGGD ALIFKKGSKR FIAHADEESP DNVNDIDAKE QFSSESSGAN 840
  841 DEVFDDLEAK GVFIWKDVCF TIPYEGGKRM LLDNVSGYCI PGTMTALMGE SGAGKTTLLN 900
  901 TLAQRNVGII TGDMLVNGRP IDASFERRTG YVQQQDIHIA ELTVRESLQF SARMRRPQHL 960
  961 PDSEKMDYVE KIIRVLGMEE YAEALVGEVG CGLNVEQRKK LSIGVELVAK PDLLLFLDEP1020
 1021 TSGLDSQSSW AIIQLLRKLS KAGQSILCTI HQPSATLFEE FDRLLLLRKG GQTVYFGDIG1080
 1081 KNSATILNYF ERNGARKCDS SENPAEYILE AIGAGATASV KEDWHEKWLN SVEFEQTKEK1140
 1141 VQDLINDLSK QETKSEVGDK PSKYATSYAY QFRYVLIRTS TSFWRSLNYI MSKMMLMLVG1200
 1201 GLYIGFTFFN VGKSYVGLQN AMFAAFISII LSAPAMNQIQ GRAIASRELF EVRESQSNMF1260
 1261 HWSLVLITQY LSELPYHLFF STIFFVSSYF PLRIFFEASR SAVYFLNYCI MFQLYYVGLG1320
 1321 LMILYMSPNL PSANVILGLC LSFMLSFCGV TQPVSLMPGF WTFMWKASPY TYFVQNLVGI1380
 1381 MLHKKPVVCK KKELNYFNPP NGSTCGEYMK PFLEKATGYI ENPDATSDCA YCIYEVGDNY1440
 1441 LTHISSKYSY LWRNFGIFWI YIFFNIIAMV CVYYLFHVRQ SSFLSPVSIL NKIKNIRKKK1500
 1501 Q

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ACK1 CIN8 DCG1 GNA1 MCM6 MLP1 PMD1 PMT4 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RFT1 SCL1 SGA1 SNQ2 TOS8 UMP1 YCR076C YDR179W-A YJL132W YKR070W YLR211C YLR290C
View Details	Qiu et al. (2008)		PDR5 QDR3 SNQ2 YOR1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	TOS3	SNQ2	2	Unpublished Fields Lab Data
View Screen	NSE4	SNQ2	2	Unpublished Fields Lab Data
View Screen	YLR415C	SNQ2	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SNQ2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..150]	deduced	N/A	No confident structure predictions are available.
2	View Details	[151..432]	PSI-BLAST	125.9897	MJ0796
3	View Details	[433..498]	deduced	N/A	No confident structure predictions are available.
4	View Details	[499..633] [652..831]	PSI-BLAST	169.9897	MsbA
5	View Details	[634..651] [832..1101]	PSI-BLAST	169.9897	MsbA
6	View Details	[1102..1392]	MSA	9.532969	View MSA. No confident structure predictions are available.
7	View Details	[1393..1501]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
lipid transporter activity	7.47642599298853	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	5.57844095962502	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	5.57813579764186	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	5.57813579764186	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	5.5689620139321	bayes_pls_golite062009
primary active transmembrane transporter activity	5.55992639965745	bayes_pls_golite062009
active transmembrane transporter activity	5.50005167063544	bayes_pls_golite062009
ATPase activity, coupled	4.98276715440477	bayes_pls_golite062009
ATPase activity	4.69795387297193	bayes_pls_golite062009
nucleoside-triphosphatase activity	4.45923622153365	bayes_pls_golite062009
sterol transporter activity	4.45355165759136	bayes_pls_golite062009
pyrophosphatase activity	4.39781350157199	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	4.38133275795019	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4.38085303582726	bayes_pls_golite062009
transporter activity	3.71239480053329	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.57926427233638	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
hydrolase activity	3.14498892233323	bayes_pls_golite062009
transmembrane transporter activity	3.13960906549884	bayes_pls_golite062009
substrate-specific transporter activity	3.1318898376276	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
iron ion transmembrane transporter activity	3.05511942104215	bayes_pls_golite062009
ATP binding	3.01346604299372	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.00745742755195	bayes_pls_golite062009
drug transmembrane transporter activity	2.97119034312001	bayes_pls_golite062009
adenyl ribonucleotide binding	2.96271391116269	bayes_pls_golite062009
adenyl nucleotide binding	2.91131545957759	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.88476360771975	bayes_pls_golite062009
cholesterol transporter activity	2.72457626066894	bayes_pls_golite062009
purine ribonucleotide binding	2.70262534541085	bayes_pls_golite062009
ribonucleotide binding	2.70178191749524	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
purine nucleotide binding	2.6583477492092	bayes_pls_golite062009
nucleotide binding	2.62374702628143	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.61311581579476	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
amine-transporting ATPase activity	2.26176677225712	bayes_pls_golite062009
	2.20174656498665	bayes_pls_golite062009
syntaxin-13 binding	2.15656963765495	bayes_pls_golite062009
apolipoprotein A-I binding	2.15656963765495	bayes_pls_golite062009
apolipoprotein receptor activity	2.15656963765495	bayes_pls_golite062009
apolipoprotein A-I receptor activity	2.15656963765495	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	1.95782378818812	bayes_pls_golite062009
binding	1.84115074893083	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	1.82177108193332	bayes_pls_golite062009
fluconazole transporter activity	1.75428613304237	bayes_pls_golite062009
azole transporter activity	1.75428613304237	bayes_pls_golite062009
nucleic acid binding	1.62884148289979	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.58971273330352	bayes_pls_golite062009
DNA binding	1.53176391519962	bayes_pls_golite062009
transcription regulator activity	1.49517431175162	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	1.41230790551643	bayes_pls_golite062009
peptide-transporting ATPase activity	1.37783759788533	bayes_pls_golite062009
cation channel activity	1.33585529285301	bayes_pls_golite062009
signal recognition particle binding	1.23869719200594	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
peptide transporter activity	1.19353064661766	bayes_pls_golite062009
potassium channel activity	1.17288958041707	bayes_pls_golite062009
GTPase activity	1.16964908174651	bayes_pls_golite062009
voltage-gated cation channel activity	1.00384984515681	bayes_pls_golite062009
voltage-gated ion channel activity	0.889208591820696	bayes_pls_golite062009
voltage-gated channel activity	0.871525745291603	bayes_pls_golite062009
	0.869999622006359	bayes_pls_golite062009
ion channel activity	0.848261056209476	bayes_pls_golite062009
channel activity	0.806331380134838	bayes_pls_golite062009
passive transmembrane transporter activity	0.806331380134838	bayes_pls_golite062009
substrate-specific channel activity	0.799997700906738	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
phospholipid transporter activity	0.755445322666929	bayes_pls_golite062009
motor activity	0.677658554107	bayes_pls_golite062009
gated channel activity	0.650050847753837	bayes_pls_golite062009
DNA-dependent ATPase activity	0.62832939629645	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	0.442220326523999	bayes_pls_golite062009
anion transmembrane transporter activity	0.43332053110728	bayes_pls_golite062009
catalytic activity	0.368034275052766	bayes_pls_golite062009
transcription factor activity	0.344643343870781	bayes_pls_golite062009
canalicular bile acid transmembrane transporter activity	0.301752323171649	bayes_pls_golite062009
signal transducer activity	0.286367085584159	bayes_pls_golite062009
molecular transducer activity	0.286367085584159	bayes_pls_golite062009
G-protein coupled receptor activity	0.169034229773346	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
microtubule motor activity	0.11674780318211	bayes_pls_golite062009
protein transporter activity	0.104820191623932	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
structure-specific DNA binding	0.050232896280066	bayes_pls_golite062009
transcription activator activity	0.0291047953833683	bayes_pls_golite062009
ribonucleoprotein binding	0.0181245554613096	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	0.0122470146764899	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2