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Protein Overview: TOS3

General Information:
Name(s) found: TOS3 / YGL179C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 560 amino acids

    Gene Ontology:
    Cellular Component: [NOT]nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: glucose metabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLLKEPVQP LPRSSLLYNN ASNSSSRIKE TRKVKLLYNP LTKRQILNNF EILATLGNGQ  60
   61 YGKVKLARDL GTGALVAIKI LNRFEKRSGY SLQLKVENPR VNQEIEVMKR CHHENVVELY 120
  121 EILNDPESTK VYLVLEYCSR GPVKWCPENK MEIKAVGPSI LTFQQSRKVV LDVVSGLEYL 180
  181 HSQGITHRDI KPSNLLISSN GTVKISDFGV AMSTATGSTN IQSSHEQLLK SRALGTPAFF 240
  241 APELCSTEKE YSCSSAIDIW SLGVTIYCLL FGKLPFNANS GLELFDSIIN KPLEFPSYEE 300
  301 MLNGATSGIT MEEYTDAKDL LKKLLQKDPD KRIKLADIKV HPFMCHYGKS DAASVLTNLE 360
  361 TFHELKVSPP SSCKRVELVS LPVNSSFASL DSVYMENFDH NNLRTGADRN STYSPSIYDA 420
  421 NTLSPSAYHN IGSRESSYSS FSSFTSSTAF ASQISIQDAP AIGDQQCLIG ESGSSLRVNS 480
  481 CEFPQYTTMS PVGEYPFEST EASLSSTLTP VGNVPQRIKA HLVEGKSNSK DDLRIEADAS 540
  541 LVFEASDAQR TRRRMSLYKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AIP1 COF1 CYR1 ESL2 GCN1 KAP114 PHO81 REX2 SNF4 SRV2 TOS3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TOS3 DTR1 2 Unpublished Fields Lab Data
    View Screen TOS3 SMA1 2 Unpublished Fields Lab Data
    View Screen TOS3 KAR9 2 Unpublished Fields Lab Data
    View Screen TOS3 TUP1 2 Unpublished Fields Lab Data
    View Screen TOS3 SNQ2 2 Unpublished Fields Lab Data
    View Screen TOS3 ENT4 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..41]
    [97..119]
    [137..390]    		 PSI-BLAST 380.0 cAMP-dependent PK, catalytic subunit
    2 View Details [42..96]
    [120..136]
    [391..439]    		 PSI-BLAST 380.0 cAMP-dependent PK, catalytic subunit
    3 View Details [440..560] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein kinase activity
    		•  5.17195961442593 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.46123870227889 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • binding
    		•  2.31930216202447 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.282849280638519 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle