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Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of, within or between cells. Enables the transfer of a substance from one side of a membrane to the other. Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: xenobiotic-transporting ATPase activity
Acc: GO:0008559
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
Synonyms:
  • ATP phosphohydrolase (xenobiotic-exporting)
  • multidrug resistance exporter
  • GO:0008560
  • steroid ABC transporter
  • pleiotropic-drug-resistance protein
  • GO:0005226
  • multidrug-resistance protein
  • steroid-transporting ATPase activity
  • MDR protein
  • P-glycoprotein
  • ATP phosphohydrolase (steroid-exporting)
  • xenobiotic ABC transporter
  • PDR protein
Proteins in PDR annotated with:
   This term: 48 [Search]
   Term or descendants: 48 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008559 - xenobiotic-transporting ATPase activity (interactive image map)

YRC Informatics Platform - Version 3.0
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