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Protein Overview: GUS1

General Information:
Name(s) found: GUS1 / YGL245W [SGD]
Description(s) found:
Found 18 descriptions.
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  • Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 708 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    methionyl glutamyl tRNA synthetase complex [IDALink to PubMed article]
    Biological Process: glutamyl-tRNA aminoacylation [IDALink to PubMed article]
    Molecular Function: glutamate-tRNA ligase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSTLTINGK APIVAYAELI AARIVNALAP NSIAIKLVDD KKAPAAKLDD ATEDVFNKIT  60
   61 SKFAAIFDNG DKEQVAKWVN LAQKELVIKN FAKLSQSLET LDSQLNLRTF ILGGLKYSAA 120
  121 DVACWGALRS NGMCGSIIKN KVDVNVSRWY TLLEMDPIFG EAHDFLSKSL LELKKSANVG 180
  181 KKKETHKANF EIDLPDAKMG EVVTRFPPEP SGYLHIGHAK AALLNQYFAQ AYKGKLIIRF 240
  241 DDTNPSKEKE EFQDSILEDL DLLGIKGDRI TYSSDYFQEM YDYCVQMIKD GKAYCDDTPT 300
  301 EKMREERMDG VASARRDRSV EENLRIFTEE MKNGTEEGLK NCVRAKIDYK ALNKTLRDPV 360
  361 IYRCNLTPHH RTGSTWKIYP TYDFCVPIVD AIEGVTHALR TIEYRDRNAQ YDWMLQALRL 420
  421 RKVHIWDFAR INFVRTLLSK RKLQWMVDKD LVGNWDDPRF PTVRGVRRRG MTVEGLRNFV 480
  481 LSQGPSRNVI NLEWNLIWAF NKKVIDPIAP RHTAIVNPVK IHLEGSEAPQ EPKIEMKPKH 540
  541 KKNPAVGEKK VIYYKDIVVD KDDADVINVD EEVTLMDWGN VIITKKNDDG SMVAKLNLEG 600
  601 DFKKTKHKLT WLADTKDVVP VDLVDFDHLI TKDRLEEDES FEDFLTPQTE FHTDAIADLN 660
  661 VKDMKIGDII QFERKGYYRL DALPKDGKPY VFFTIPDGKS VNKYGAKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARC1 EFB1 GUS1 HXK1 ILV1 MES1 SSZ1 TEF4 YEF3
    View Details Krogan NJ, et al. (2006) GUS1 QRI1 SLX4 UBA4 YOR097C
    View Details Gavin AC, et al. (2006) ARC1 GUS1 MES1
    View Details Gavin AC, et al. (2002) ACC1 ARO1 BLM10 CAM1 CCT8 CDC55 CIN1 CLU1 CPA2 EFB1 ERG13 FAP1 FDH1 GCN20 GFA1 GUS1 HHF1, HHF2 HOS2 HOS4 HSC82 IDH2 ILV1 IML1 KAP123 KAP95 KEL1 LTE1 LYS12 MGA2 MKT1 MRPL3 MYO5 NEW1 OLA1 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PSA1 PUP1 PUP2 PUP3 RAD51 RAD52 RFA1 RPA135 RPB2 RPN10 RPN11 RPN12 RPN8 RPN9 RPT3 RPT5 RPT6 RRD2 RTS1 RTS3 RVB2 SAM1 SBP1 SCL1 SEC27 SET3 SIF2 SMC3 SNT1 SRP1 TCB1 TDH2 TDH3 TEF1, TEF2 TEF4 TIF1, TIF2 TPD3 TSA1 TUB3 URA7 VAS1 YBL104C YHB1 YOL098C YOR1 YRA1 ZDS1 ZDS2
    View Details Ho Y, et al. (2002) AAC1 AAC3 AAT2 ACC1 ACH1 ACO1 ADE5,7 ADH2 ADR1 AFR1 AHA1 AHP1 ARC1 ARF1 ARO1 ARP2 ARP7 ATG11 ATG12 ATG17 ATP3 AVO1 BEM3 CAR2 CCT2 CCT6 CDC12 CDC14 CDC15 CDC33 CLU1 COF1 COR1 CPA2 CPR1 CPR3 CPR6 CYR1 CYS4 DIG1 DIG2 DOG1 DOG2 DUG2 DUT1 EGD1 EGD2 ELG1 ERB1 ERG13 ERG6 FET4 FPR1 FRS2 GCD11 GFA1 GND1 GND2 GPA2 GRX1 GUS1 HAS1 HEF3 HHF1, HHF2 HXT6 HXT7 IDH2 IMD4 IPP1 ISA2 KGD1 KSS1 LRO1 LSP1 MDH1 MEC1 MET18 MET6 MKT1 MRT4 MSE1 MSK1 MUB1 NAP1 NGL2 NOC2 NOC3 NOG1 NPA3 NSA1 NTF2 NUG1 OLA1 OYE2 PFK1 PHO84 PIL1 PIM1 PMA1 PMA2 PPX1 PRB1 PRM2 PRP43 PTC7 PYC1 PYC2 REP1 RET1 REX2 RFC1 RFC2 RFC4 RGC1 RGD1 RNQ1 RNR2 RPA135 RPA190 RPA49 RPB5 RPC19 RPC25 RPC34 RPC40 RPC82 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPO26 RPO31 RPT1 RPT3 RSN1 RVB1 RVS167 SAH1 SAN1 SCP160 SCS2 SEC18 SEC27 SEC53 SEN1 SEN15 SES1 SNU13 SOD1 SPB4 SSQ1 STE11 STE12 STE7 TBS1 TCB1 TEC1 TEF4 TEM1 TFP1 THS1 TIF1, TIF2 TIF6 TMA19 TMA29 TSA2 TSC11 TYR1 UBA1 UBI4 UBR2 VMA22 VMA4 VMA5 WTM1 YDR239C YFL042C YGR066C YHR020W YHR033W YHR112C YNK1 YNL208W YTM1
    View Details Qiu et al. (2008) ARC1 FRS1 FRS2 GUS1 MES1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GUS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..177] PSI-BLAST 8.30103 Crystal structure of an insect delta-class glutathione S-transferase from a DDT-resistant strain of the malaria vector Anopheles gambiae
    2 View Details [178..708] PSI-BLAST 150.0 Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain; Glutaminyl-tRNA synthetase (GlnRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.16276509815667 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.16276509815667 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.13957775963187 bayes_pls_golite062009
  • ligase activity
    		•  6.11211476973434 bayes_pls_golite062009
  • glutamate-tRNA ligase activity
    		•  5.13420185144914 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  4.61484562096458 bayes_pls_golite062009
  • glutamine-tRNA ligase activity
    		•  4.45248364270113 bayes_pls_golite062009
  • structural molecule activity
    		•  4.261982318682 bayes_pls_golite062009
  • methionine-tRNA ligase activity
    		•  2.56893064485672 bayes_pls_golite062009
  • catalytic activity
    		•  2.37674226834122 bayes_pls_golite062009
  • 5S rRNA binding
    		•  2.25646775578129 bayes_pls_golite062009
  • rRNA binding
    		•  2.12571610259264 bayes_pls_golite062009
  • tyrosine-tRNA ligase activity
    		•  1.88984817882585 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.64840822019417 bayes_pls_golite062009
  • arginine-tRNA ligase activity
    		•  1.50161401062914 bayes_pls_golite062009
  • tryptophan-tRNA ligase activity
    		•  1.14187887833901 bayes_pls_golite062009
  • binding
    		•  1.11291710031577 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.06535308346284 bayes_pls_golite062009
  • cysteine-tRNA ligase activity
    		•  0.844943947059557 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.625793556381714 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle