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Protein Overview: CCT6

General Information:
Name(s) found: CCT6 / YDR188W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 546 amino acids

    Gene Ontology:
    Cellular Component: chaperonin-containing T-complex [IPILink to PubMed article][TASLink to PubMed article]
    cytoskeleton [TASLink to PubMed article]
    cytoplasm [TASLink to PubMed article]
    Biological Process: cytoskeleton organization [TASLink to PubMed article]
    protein folding [TASLink to PubMed article]
    Molecular Function: unfolded protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLQLLNPKA ESLRRDAALK VNVTSAEGLQ SVLETNLGPK GTLKMLVDGA GNIKLTKDGK  60
   61 VLLTEMQIQS PTAVLIARAA AAQDEITGDG TTTVVCLVGE LLRQAHRFIQ EGVHPRIITD 120
  121 GFEIARKESM KFLDEFKISK TNLSNDREFL LQVARSSLLT KVDADLTEVL TPIVTDAVLS 180
  181 VYDAQADNLD LHMVEIMQMQ HLSPKDTTFI KGLVLDHGGR HPDMPTRVKN AYVLILNVSL 240
  241 EYEKTEVNSG FFYSSADQRD KLAASERKFV DAKLKKIIDL KNEVCGMDPD KGFVIINQKG 300
  301 IDPMSLDVFA KHNILALRRA KRRNMERLQL VTGGEAQNSV EDLSPQILGF SGLVYQETIG 360
  361 EEKFTYVTEN TDPKSCTILI KGSTHYALAQ TKDAVRDGLR AVANVLKDKN IIPGAGAFYI 420
  421 ALSRYLRSAN MNKLGAKGKT KTGIEAFAEA LLVIPKTLVK NSGFDPLDVL AMVEDELDDA 480
  481 QDSDETRYVG VDLNIGDSCD PTIEGIWDSY RVLRNAITGA TGIASNLLLC DELLRAGRST 540
  541 LKETPQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CCT2 CCT3 CCT4 CCT5 CCT6 GCN20 TCP1
    View Details (MIPS) Mewes HW, et al. (2004) CCT2 CCT3 CCT4 CCT5 CCT6 CCT7 CCT8 TCP1
    View Details Krogan NJ, et al. (2006) CCT2 CCT4 CCT6
    View Details Gavin AC, et al. (2002) AHA1 ATP11 CAF130 CAF40 CCR4 CCT6 CCT7 CDC36 CDC39 COP1 FAS2 GCN1 MOT2 NOT3 NOT5 PDC1 POL1 POL12 POP2 PRI1 PRI2 RVB2 SAM1 SEC27 TAP42 TFC7 TFP1 YRA1
    View Details Ho Y, et al. (2002) ACC1 ACO1 AHA1 ARP2 BGL2 BRX1 BTN2 BUD3 CAF4 CCT2 CCT3 CCT5 CCT6 CDC14 CDC33 CDC55 CFT1 CIN8 CLU1 COP1 CPR6 CTR1 DHH1 EAP1 EGD2 ENT2 ERB1 FAA1 FAA4 FMP10 FZO1 GAL7 GCD11 GDT1 GLT1 GND1 GPA1 GSF2 GUS1 HAS1 HGH1 HIR1 HTB1 HXT7 IDH1 KRE33 LAP4 MAE1 MDJ1 MEH1 MET6 MNP1 MRT4 MTC5 MUB1 MYO2 NAN1 NDE1 NEW1 NOC2 NOC3 NOG1 NOP56 NPA3 NPR2 NSA1 NUG1 OSH7 PEX7 PFK1 PFS2 POL5 POX1 PPH21 PPH22 PRB1 PRP43 PRP46 PWP1 RAD28 RMT2 RNQ1 RNR2 RPN6 RPN7 RPT3 RPT4 RRP12 RVB1 SAH1 SAP155 SAP185 SAP190 SCS2 SEC27 SEC28 SEC53 SEC6 SEH1 SEN2 SIT4 SOF1 SPB4 SRP54 SSD1 SSQ1 STE4 STI1 TAP42 TCP1 THI21 TIF4631 TIF6 TMA19 TPD3 UBR1 UBR2 UTP10 UTP22 UTP7 WTM1 WTM2 YBL029W YCR076C YHR033W YMR196W YTM1
    View Details Qiu et al. (2008) CCT2 CCT3 CCT4 CCT5 CCT6 CCT7 CCT8 SSA2 TCP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB3 No Comments Hazbun TR, et al. (2003)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103]
    [137..413]
    [504..546]    		 PSI-BLAST 854.9897 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
    2 View Details [104..136]
    [414..503]    		 PSI-BLAST 854.9897 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  7.60116801069598 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.6934849790316 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.40373598585301 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  3.28982639907979 bayes_pls_golite062009
  • binding
    		•  2.07154556649829 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.67284737458957 bayes_pls_golite062009
  • DNA binding
    		•  1.60256620441721 bayes_pls_golite062009
  • transporter activity
    		•  1.27879339110564 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08697283907212 bayes_pls_golite062009
  • chaperone binding
    		•  0.91200031047441 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.828920415160435 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.787685249362834 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.75018875403424 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.69634667457441 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.682843768728088 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.680378643689288 bayes_pls_golite062009
  • protein binding
    		•  0.634982583867058 bayes_pls_golite062009
  • ATPase activity
    		•  0.584574936611857 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.573106450426516 bayes_pls_golite062009
  • catalytic activity
    		•  0.424959044318554 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.280310103153739 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.275534581026027 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  0.26275673855778 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.252704226951294 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.243984617084631 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.205808843369749 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.202279803135899 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.20198255686005 bayes_pls_golite062009
  • transferase activity
    		•  0.18639662517366 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.16424934648837 bayes_pls_golite062009
  • kinase activity
    		•  0.0871496920547826 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0778814959589007 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0491351110520448 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle