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Protein Overview: HXT7

General Information:
Name(s) found: HXT7 / YDR342C [SGD]
Description(s) found:
Found 31 descriptions.
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  • High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 570 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    plasma membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: hexose transport [TASLink to PubMed article]
    Molecular Function: fructose transmembrane transporter activity [TASLink to PubMed article]
    glucose transmembrane transporter activity [IDALink to PubMed article][TASLink to PubMed article]
    mannose transmembrane transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQDAAIAEQ TPVEHLSAVD SASHSVLSTP SNKAERDEIK AYGEGEEHEP VVEIPKRPAS  60
   61 AYVTVSIMCI MIAFGGFVFG WDTGTISGFI NQTDFIRRFG MKHKDGTNYL SKVRTGLIVS 120
  121 IFNIGCAIGG IILSKLGDMY GRKVGLIVVV VIYIIGIIIQ IASINKWYQY FIGRIISGLG 180
  181 VGGIAVLSPM LISEVSPKHL RGTLVSCYQL MITAGIFLGY CTNFGTKNYS NSVQWRVPLG 240
  241 LCFAWALFMI GGMTFVPESP RYLAEVGKIE EAKRSIAVSN KVAVDDPSVL AEVEAVLAGV 300
  301 EAEKLAGNAS WGELFSSKTK VLQRLIMGAM IQSLQQLTGD NYFFYYGTTI FKAVGLSDSF 360
  361 ETSIVLGIVN FASTFVGIYV VERYGRRTCL LWGAASMTAC MVVYASVGVT RLWPNGQDQP 420
  421 SSKGAGNCMI VFACFYIFCF ATTWAPIPYV VVSETFPLRV KSKAMSIATA ANWLWGFLIG 480
  481 FFTPFITGAI NFYYGYVFMG CLVFMFFYVL LVVPETKGLT LEEVNTMWEE GVLPWKSASW 540
  541 VPPSRRGANY DAEEMTHDDK PLYKRMFSTK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HXT6 HXT7
    View Details Krogan NJ, et al. (2006) AAC3 ATG32 HXT7 PET9 PMR1
    View Details Ho Y, et al. (2002) AAC3 ABP1 ACO1 ADK1 AHP1 AIM41 AIM46 ARO1 ARP3 ATP4 AVO1 BGL2 BUD14 BZZ1 CAR2 CBP6 CCT6 CDC14 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 EDC3 EDE1 EGD2 ENP1 ERB1 FET4 FRS2 FYV10 GAL2 GAS1 GCD11 GCN1 GCN3 GID7 GID8 GND1 GPH1 GUS1 HAS1 HEF3 HHF1, HHF2 HOR2 HRR25 HSP104 HXT6 HXT7 HYP2 IPP1 KAP95 LAS17 LEM3 LOC1 LSP1 LTV1 MCX1 MDH1 MDS3 MET6 MGE1 MNP1 MRT4 MTC5 MUB1 NDE1 NMD3 NMD5 NOC2 NOC3 NOG1 NPA3 NSA1 NUG1 OYE2 PDC6 PEP1 PET10 PET9 PEX19 PGM2 PHO84 PIL1 PIN4 PKH2 PRP43 PSR2 PTC4 PUF3 RFA3 RGI1 RHR2 RIO2 RMD5 RPC19 RPM2 RPN1 RPN12 RPP0 RTC3 RVS167 SAH1 SAP185 SAP190 SAS10 SCP1 SCS2 SEC2 SEC23 SEC53 SES1 SFB3 SGM1 SIT4 SLA1 SLC1 SPB4 SPS1 SQT1 SSQ1 TCP1 TFP1 TIF6 TIM21 TMA19 TRP3 TRP5 TSR1 TUP1 UBR2 VID28 VID30 VMA4 VMA6 VPS8 YBL036C YBR225W YER138C YHM2 YJR141W YLR326W YSC84 YTM1
    View Details Qiu et al. (2008) HXT6 HXT7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run YNL313C No Comments Hazbun TR, et al. (2003)
    View Run YMR185W No Comments Hazbun TR, et al. (2003)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run GWT1 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HXT7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..257]
    [306..517]    		 PSI-BLAST 504.0103 No description for 1ja5A_ was found.
    2 View Details [258..305]
    [518..570]    		 PSI-BLAST 504.0103 No description for 1ja5A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glycerol transmembrane transporter activity
    		•  7.11654923455995 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  6.7545566917184 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  6.7545566917184 bayes_pls_golite062009
  • glycerol-3-phosphate transmembrane transporter activity
    		•  5.74077413704789 bayes_pls_golite062009
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.54194478414824 bayes_pls_golite062009
  • hexose phosphate transmembrane transporter activity
    		•  3.3746965264994 bayes_pls_golite062009
  • glucose-6-phosphate transmembrane transporter activity
    		•  3.3746965264994 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  2.99050613058546 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  2.99050613058546 bayes_pls_golite062009
  • monosaccharide transmembrane transporter activity
    		•  2.63293544825311 bayes_pls_golite062009
  • carbohydrate transmembrane transporter activity
    		•  2.62141276633776 bayes_pls_golite062009
  • sugar transmembrane transporter activity
    		•  2.47557586092261 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.21266150105753 bayes_pls_golite062009
  • solute:hydrogen symporter activity
    		•  2.10485633822652 bayes_pls_golite062009
  • binding
    		•  1.89539096965643 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.79369588808394 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • sugar binding
    		•  0.285073104957756 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle