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Protein Overview: DCP1

General Information:
Name(s) found: DCP1 / YOL149W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 231 amino acids

    Gene Ontology:
    Cellular Component: cytoplasmic mRNA processing body [IDALink to PubMed article][IMPLink to PubMed article]
    Biological Process: deadenylation-dependent decapping of nuclear-transcribed mRNA [IDALink to PubMed article]
    mRNA catabolic process [TASLink to PubMed article]
    Molecular Function: enzyme activator activity [IDALink to PubMed article]
    mRNA binding [IPILink to PubMed article]
    m7G(5')pppN diphosphatase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [NCBI BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGAATAAEN SATQLEFYRK ALNFNVIGRY DPKIKQLLFH TPHASLYKWD FKKDEWNKLE  60
   61 YQGVLAIYLR DVSQNTNLLP VSPQEVDIFD SQNGSNNIQV NNGSDNSNRN SSGNGNSYKS 120
  121 NDSLTYNCGK TLSGKDIYNY GLIILNRINP DNFSMGIVPN SVVNKRKVFN AEEDTLNPLE 180
  181 CMGVEVKDEL VIIKNLKHEV YGIWIHTVSD RQNIYELIKY LLENEPKDSF A

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) Manuscript in preparation. DCP1 DCP2 EDC3
    View Details Krogan NJ, et al. (2006) DCP1 DCP2 EDC2 EDC3 PBY1
    View Details Gavin AC, et al. (2006) DCP1 DCP2 EDC3
    View Details Gavin AC, et al. (2002) DCP1 DCP2 EDC3 RPM2
    View Details Ho Y, et al. (2002) ABP1 ACO1 AIM41 ATP4 BUD14 CAR2 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 EDC3 EDE1 EGD2 ENP1 GAS1 GCN3 GPH1 HHF2, HHF1 HRR25 HSP104 HXT7 HYP2 IPP1 LOC1 LSP1 LTV1 MDH1 MDS3 MGE1 NSA1 NUG1 OYE2 PEX19 PIL1 PIN4 PTC4 PUF3 RIO2 RPC19 RPM2 SAP185 SAP190 SAS10 SEC2 SEC23 SES1 SFB3 SGM1 SIT4 TMA19 TSR1 VMA4 YBR225W YER138C
    View Details Qiu et al. (2008) DCP1 DCP2 DCS1 DCS2 EDC3 KEM1 LSM1 PAT1 RPB4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen LSM2 DCP1 2 Uetz P, et al. (2000)
    View Screen LSM4 DCP1 2 Uetz P, et al. (2000)
    View Screen LSM8 DCP1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DCP1 Huh WK, et al. (2003)
    [View in YRC Public Image Repository] (1 experiment(s)and 3 images)

    Protein Structure Data


    [What does the above image mean?] [View Top Sequence Alignments]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..231] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • m7G(5')pppN diphosphatase activity
    		•  7.99932341873003 bayes_pls_golite062009
  • RNA binding
    		•  2.55097133772064 bayes_pls_golite062009
  • binding
    		•  2.05807773136211 bayes_pls_golite062009
  • protein binding
    		•  1.42524730253104 bayes_pls_golite062009
  • mRNA binding
    		•  1.14723961298833 bayes_pls_golite062009
  • structural molecule activity
    		•  0.748515192577617 bayes_pls_golite062009
  • hydrolase activity
    		•  0.223484823985325 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0780836662661571 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by:     Michael Riffle