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Protein Overview: SEC23

General Information:
Name(s) found: SEC23 / YPR181C [SGD]
Description(s) found:
Found 34 descriptions.
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  • GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 768 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    COPII vesicle coat [TASLink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IMPLink to PubMed article][TASLink to PubMed article]
    autophagy [IMPLink to PubMed article]
    ER-associated protein catabolic process [IMPLink to PubMed article]
    Molecular Function: GTPase activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFETNEDIN GVRFTWNVFP STRSDANSNV VPVGCLYTPL KEYDELNVAP YNPVVCSGPH  60
   61 CKSILNPYCV IDPRNSSWSC PICNSRNHLP PQYTNLSQEN MPLELQSTTI EYITNKPVTV 120
  121 PPIFFFVVDL TSETENLDSL KESIITSLSL LPPNALIGLI TYGNVVQLHD LSSETIDRCN 180
  181 VFRGDREYQL EALTEMLTGQ KPTGPGGAAS HLPNAMNKVT PFSLNRFFLP LEQVEFKLNQ 240
  241 LLENLSPDQW SVPAGHRPLR ATGSALNIAS LLLQGCYKNI PARIILFASG PGTVAPGLIV 300
  301 NSELKDPLRS HHDIDSDHAQ HYKKACKFYN QIAQRVAANG HTVDIFAGCY DQIGMSEMKQ 360
  361 LTDSTGGVLL LTDAFSTAIF KQSYLRLFAK DEEGYLKMAF NGNMAVKTSK DLKVQGLIGH 420
  421 ASAVKKTDAN NISESEIGIG ATSTWKMASL SPYHSYAIFF EIANTAANSN PMMSAPGSAD 480
  481 RPHLAYTQFI TTYQHSSGTN RIRVTTVANQ LLPFGTPAIA ASFDQEAAAV LMARIAVHKA 540
  541 ETDDGADVIR WLDRTLIKLC QKYADYNKDD PQSFRLAPNF SLYPQFTYYL RRSQFLSVFN 600
  601 NSPDETAFYR HIFTREDTTN SLIMIQPTLT SFSMEDDPQP VLLDSISVKP NTILLLDTFF 660
  661 FILIYHGEQI AQWRKAGYQD DPQYADFKAL LEEPKLEAAE LLVDRFPLPR FIDTEAGGSQ 720
  721 ARFLLSKLNP SDNYQDMARG GSTIVLTDDV SLQNFMTHLQ QVAVSGQA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SEC13 SEC16 SEC23 SFB2
    View Details (MIPS) Mewes HW, et al. (2004) EMP24 ERP1 ERP2 ERV25 ERV46 SAR1 SEC13 SEC16 SEC23 SEC24 SEC31
    View Details Krogan NJ, et al. (2006) BUG1 GRH1 SEC23 SEC24 SFB2
    View Details Gavin AC, et al. (2006) SEC13 SEC16 SEC23 SEC24 SFB2
    View Details Gavin AC, et al. (2002) CKA1 CKA2 CKB1 DBP2 MRPS28 NUP120 NUP145 NUP84 NUP85 RPP2B SEC13 SEC16 SEC23 SEC31 SEH1 STM1
    View Details Ho Y, et al. (2002) AAC3 ABP1 ACO1 ADH2 AIM41 ATP4 BUD14 BUD32 CAR2 CDC16 CDC25 CDC33 CKA2 COR1 CPR6 CRM1 CRZ1 CYS4 DCP1 DCP2 DIA4 DNM1 DUN1 EDC3 EDE1 EGD2 ENP1 ERB1 FPR3 GAS1 GCN3 GLC7 GPH1 GRX3 GRX4 HEF3 HHF1, HHF2 HRR25 HSP104 HXT7 HYP2 IDP2 IMD2 IMD4 IPP1 KAE1 KRE33 KRI1 LOC1 LSP1 LTV1 MDH1 MDS3 MES1 MGE1 MKT1 MMS4 MUS81 NHP2 NOP12 NOP2 NPA3 NSA1 NUG1 OYE2 PEX19 PHO81 PIL1 PIN4 PTC4 PUF3 PWP1 RAD53 RIO2 RNH202 RPC10 RPC19 RPF2 RPM2 RPN1 RPN5 RPN6 RPT1 SAP185 SAP190 SAS10 SEC18 SEC2 SEC23 SEC53 SES1 SFB3 SGM1 SGO1 SIT4 SRS2 TAF14 TGL1 TMA19 TMA29 TSR1 UBI4 URA7 UTP22 VMA4 YBR225W YER138C YHB1 YHR033W YRA1
    View Details Qiu et al. (2008) EMP24 ERP1 ERP2 ERV25 ERV46 GLO3 HLJ1 SAR1 SEC13 SEC16 SEC23 SEC24 SEC31 SFB2 SFB3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..626]
    [749..768]    		 PSI-BLAST 11000.0 Sec23
    2 View Details [627..748] PSI-BLAST 11000.0 Sec23


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle