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Protein Overview: SEC18

General Information:
Name(s) found: SEC18 / YBR080C [SGD]
Description(s) found:
Found 25 descriptions.
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  • ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 758 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    extrinsic to plasma membrane [IDALink to PubMed article]
    Biological Process: vacuole inheritance [IDALink to PubMed article]
    ER to Golgi vesicle-mediated transport [TASLink to PubMed article]
    vacuole fusion, non-autophagic [IMPLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKIPGFGKA AANHTPPDMT NMDTRTRHLK VSNCPNNSYA LANVAAVSPN DFPNNIYIII  60
   61 DNLFVFTTRH SNDIPPGTIG FNGNQRTWGG WSLNQDVQAK AFDLFKYSGK QSYLGSIDID 120
  121 ISFRARGKAV STVFDQDELA KQFVRCYESQ IFSPTQYLIM EFQGHFFDLK IRNVQAIDLG 180
  181 DIEPTSAVAT GIETKGILTK QTQINFFKGR DGLVNLKSSN SLRPRSNAVI RPDFKFEDLG 240
  241 VGGLDKEFTK IFRRAFASRI FPPSVIEKLG ISHVKGLLLY GPPGTGKTLI ARKIGTMLNA 300
  301 KEPKIVNGPE ILSKYVGSSE ENIRNLFKDA EAEYRAKGEE SSLHIIIFDE LDSVFKQRGS 360
  361 RGDGTGVGDN VVNQLLAKMD GVDQLNNILV IGMTNRKDLI DSALLRPGRF EVQVEIHLPD 420
  421 EKGRLQIFDI QTKKMRENNM MSDDVNLAEL AALTKNFSGA EIEGLVKSAS SFAINKTVNI 480
  481 GKGATKLNTK DIAKLKVTRE DFLNALNDVT PAFGISEEDL KTCVEGGMML YSERVNSILK 540
  541 NGARYVRQVR ESDKSRLVSL LIHGPAGSGK TALAAEIALK SGFPFIRLIS PNELSGMSES 600
  601 AKIAYIDNTF RDAYKSPLNI LVIDSLETLV DWVPIGPRFS NNILQMLKVA LKRKPPQDRR 660
  661 LLIMTTTSAY SVLQQMDILS CFDNEIAVPN MTNLDELNNV MIESNFLDDA GRVKVINELS 720
  721 RSCPNFNVGI KKTLTNIETA RHDEDPVNEL VELMTQSA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RPN1 RPN10 RPN11 RPN12 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 SEC18 UBP6
    View Details (MIPS) Mewes HW, et al. (2004) SEC17 SEC18
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Ho Y, et al. (2002) AAC1 AAC3 ADE5,7 AHA1 ARC1 ARG4 ARO1 ARP2 ATG11 ATG12 ATG17 AYR1 BUD32 CAR2 COR1 CPA2 CPR6 CRM1 DIA4 ERG27 FET4 GCD11 GFA1 GPT2 GRX3 GRX4 GUS1 HEF3 IDP2 IMD2 IMD4 IPP1 KAE1 LIA1 MAE1 NPA3 OM45 PCT1 PDA1 PET10 PET9 PHO81 PIL1 PPX1 PRB1 PRE10 PRO3 PTC7 REP1 RET2 REX2 RNH202 RNR2 RPN1 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPT1 RPT3 RTN2 RVS161 SEC18 SEC21 SEC23 SEC26 SEC27 SEC28 SGO1 TCB1 TIF1, TIF2 TIF34 TIF35 TMA29 TPA1 TYR1 URA7 YHR020W YHR033W YNL181W YNL208W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB4 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx4 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC18 and COP1 Huh WK, et al. (2003)
    View Data SEC18 Huh WK, et al. (2003)
    View Data SEC18 and ANP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] PSI-BLAST 1136.522879 N-terminal domain of NSF-N, NSF-Nn; C-terminal domain of NSF-N, NSF-Nc
    2 View Details [104..218] PSI-BLAST 1136.522879 N-terminal domain of NSF-N, NSF-Nn; C-terminal domain of NSF-N, NSF-Nc
    3 View Details [219..410] PSI-BLAST 5.39794 Holliday junction helicase RuvB
    4 View Details [411..506] ORFEUS 14.82 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    5 View Details [507..690] PSI-BLAST 495.38764 Hexamerization domain of N-ethylmalemide-sensitive fusion (NSF) protein
    6 View Details [691..758] PSI-BLAST 495.38764 Hexamerization domain of N-ethylmalemide-sensitive fusion (NSF) protein


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle