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Protein Overview: ADE5,7

General Information:
Name(s) found: ADE5,7 / YGL234W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 802 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: purine nucleotide biosynthetic process [TAS]
    'de novo' IMP biosynthetic process [TAS]
    purine base metabolic process [TASLink to PubMed article]
    Molecular Function: phosphoribosylamine-glycine ligase activity [TAS]
    phosphoribosylformylglycinamidine cyclo-ligase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNILVLGNG AREHVLVTKL AQSPTVGKIY VAPGNGGTAT MDPSRVINWD ITPDVANFAR  60
   61 LQSMAVEHKI NLVVPGPELP LVNGITSVFH SVGIPVFGPS VKAAQLEASK AFSKRFMSKH 120
  121 NIPTASYDVF TNPEEAISFL QAHTDKAFVI KADGIAAGKG VIIPSSIDES VQAIKDIMVT 180
  181 KQFGEEAGKQ VVIEQFLEGD EISLLTIVDG YSHFNLPVAQ DHKRIFDGDK GLNTGGMGAY 240
  241 APAPVATPSL LKTIDSQIVK PTIDGMRRDG MPFVGVLFTG MILVKDSKTN QLVPEVLEYN 300
  301 VRFGDPETQA VLSLLDDQTD LAQVFLAAAE HRLDSVNIGI DDTRSAVTVV VAAGGYPESY 360
  361 AKGDKITLDT DKLPPHTQIF QAGTKYDSAT DSLLTNGGRV LSVTSTAQDL RTAVDTVYEA 420
  421 VKCVHFQNSY YRKDIAYRAF QNSESSKVAI TYADSGVSVD NGNNLVQTIK EMVRSTRRPG 480
  481 ADSDIGGFGG LFDLAQAGFR QNEDTLLVGA TDGVGTKLII AQETGIHNTV GIDLVAMNVN 540
  541 DLVVQGAEPL FFLDYFATGA LDIQVASDFV SGVANGCIQS GCALVGGETS EMPGMYPPGH 600
  601 YDTNGTAVGA VLRQDILPKI NEMAAGDVLL GLASSGVHSN GFSLVRKIIQ HVALPWDAPC 660
  661 PWDESKTLGE GILEPTKIYV KQLLPSIRQR LLLGLAHITG GGLVENIPRA IPDHLQARVD 720
  721 MSTWEVPRVF KWFGQAGNVP HDDILRTFNM GVGMVLIVKR ENVKAVCDSL TEEGEIIWEL 780
  781 GSLQERPKDA PGCVIENGTK LY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE5,7 DAP1 GLG1 GLG2 GSY1 GSY2
    View Details Gavin AC, et al. (2006) ADE5,7 PDR5 REB1 RPS3 RPS5 TOP1
    View Details Gavin AC, et al. (2002) ADE5,7 HHF1, HHF2 IOC3 ISW1 ISW2 ITC1 MOT1 NPL6 REB1 RFA1 RFX1 RNR2 RPC34 RPC40 RPO31 RSC2 RSC3 RSC58 RSC8 RVB2 SFH1 STH1 STO1 TAF1 TFC7 TOP1 VPS1 YBR090C-A, NHP6B
    View Details Ho Y, et al. (2002) AAC1 AAC3 ACH1 ADE5,7 ADH2 AHA1 ARC1 ARO1 ARP2 ATG11 ATG12 ATG17 BCY1 CAR2 CPA2 CPR6 DHH1 FET4 GCD11 GFA1 GPH1 GUS1 HEF3 HSP104 IPP1 JJJ1 LSM2 LSM4 LSM7 LSM8 PAT1 PFK1 PGM2 PPX1 PRB1 PRP24 PTC7 REP1 REX2 RFC1 RFC2 RFC4 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPT1 RPT3 SEC18 SEC27 SRP1 TCB1 TIF1, TIF2 TPK1 TPK3 TYR1 YHR020W YHR033W YHR214W-A YNL208W YPT7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TIM50 No Comments Hazbun TR, et al. (2003)
    View Run NOP9 No Comments Hazbun TR, et al. (2003)
    View Run YMR185W No Comments Hazbun TR, et al. (2003)
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ADE5,7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..98] PSI-BLAST 1021.0 Glycinamide ribonucleotide synthetase (GAR-syn), C-domain; Glycinamide ribonucleotide synthetase (GAR-syn), N-domain; Glycinamide ribonucleotide synthetase (GAR-syn), domain 2
    2 View Details [99..126]
    [197..220]
    [241..342]    		 PSI-BLAST 1021.0 Glycinamide ribonucleotide synthetase (GAR-syn), C-domain; Glycinamide ribonucleotide synthetase (GAR-syn), N-domain; Glycinamide ribonucleotide synthetase (GAR-syn), domain 2
    3 View Details [127..196]
    [221..240]
    [343..445]    		 PSI-BLAST 1021.0 Glycinamide ribonucleotide synthetase (GAR-syn), C-domain; Glycinamide ribonucleotide synthetase (GAR-syn), N-domain; Glycinamide ribonucleotide synthetase (GAR-syn), domain 2
    4 View Details [446..511] ORFEUS 7.0 Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain; Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
    5 View Details [512..615] PSI-BLAST 982.0 Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain; Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
    6 View Details [616..635]
    [682..802]    		 PSI-BLAST 982.0 Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain; Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
    7 View Details [636..681] PSI-BLAST 982.0 Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain; Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle