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Protein Overview: AHA1

General Information:
Name(s) found: AHA1 / YDR214W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 350 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IPILink to PubMed article]
    Biological Process: protein folding [IMPLink to PubMed article][IPILink to PubMed article]
    response to stress [IEPLink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: chaperone binding [IDALink to PubMed article]
    chaperone activator activity [IDALink to PubMed article][IPILink to PubMed article]
    ATPase activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVNNPNNWH WVDKNCIGWA KEYFKQKLVG VEAGSVKDKK YAKIKSVSSI EGDCEVNQRK  60
   61 GKVISLFDLK ITVLIEGHVD SKDGSALPFE GSINVPEVAF DSEASSYQFD ISIFKETSEL 120
  121 SEAKPLIRSE LLPKLRQIFQ QFGKDLLATH GNDIQVPESQ VKSNYTRGNQ KSSFTEIKDS 180
  181 ASKPKKNALP SSTSTSAPVS STNKVPQNGS GNSTSIYLEP TFNVPSSELY ETFLDKQRIL 240
  241 AWTRSAQFFN SGPKLETKEK FELFGGNVIS ELVSCEKDKK LVFHWKLKDW SAPFNSTIEM 300
  301 TFHESQEFHE TKLQVKWTGI PVGEEDRVRA NFEEYYVRSI KLTFGFGAVL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AHA1 BUD3 CNS1 CPR6 DIG2 DNM1 DSF1, YNR073C FRT2 GPA2 HOM6 HSC82 HSP104 HSP82 MBB1 MRPL50 PAM1 PPT1 QNS1 RMD8 RTS1 SMT3 STI1 STP4 TDH1 UTP20 YBL104C
    View Details Gavin AC, et al. (2006) AHA1 ARO1 UFD4
    View Details Gavin AC, et al. (2002) AHA1 ATP11 CAF130 CAF40 CCR4 CCT6 CDC36 CDC39 COP1 FAS2 GCN1 MOT2 NOT3 NOT5 PDC1 POL1 POL12 POP2 PRI1 PRI2 RVB2 SAM1 SEC27 TFC7 TFP1 YRA1
    View Details Ho Y, et al. (2002) AAC1 AAC3 ACC1 ADE5,7 ADH2 ADH4 AGX1 AHA1 AHP1 ARC1 ARF1 ARO1 ARO4 ARP2 ATG11 ATG12 ATG17 ATP3 BCK1 BEM2 CAR2 CCT2 CCT3 CCT5 CCT6 CDC33 CDC60 CLU1 CPA2 CPR1 CPR6 DUN1 EAP1 ECM10 EGD2 FAA4 FET3 FET4 FOL2 GAL7 GCD11 GFA1 GND1 GPA1 GPG1 GUS1 HEF3 HOM2 HOM3 HOR2 HPR1 HSP104 HTB1 IDH1 ILS1 ILV2 ILV5 IPP1 KIC1 KIN2 LHS1 LYS12 MFT1 MGE1 MGT1 MKK2 MKT1 NMD5 NPA3 NTG1 OPY1 OYE2 PDC6 PDX3 PET10 PGM1 PGM2 PHO84 PIL1 PMA1 PPH21 PPH22 PPX1 PRB1 PTC3 PTC7 QCR2 RAD24 RAD52 RAD59 RCN2 REP1 REX2 RFC1 RFC2 RFC3 RFC4 RFC5 RHR2 RIP1 RNQ1 RPA135 RPA190 RPB3 RPC40 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPN8 RPT1 RPT3 SDH2 SEC18 SEC27 SEC53 SIS1 SKG3 SLT2 SMC4 SMK1 SNF4 SOD1 SOF1 SPS1 STE4 SUB2 TCB1 TCP1 TEF4 THO2 TIF1, TIF2 TIF34 TMA19 TMA29 TRP2 TRP5 TYR1 UBA1 UBR1 URE2 VMA4 VMA8 VPS74 YER138C YHR020W YHR033W YNL208W YPT31

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data AHA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..166] MSA 5.016973 View MSA. No confident structure predictions are available.
    2 View Details [167..350] MSA 41.058996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • chaperone binding
    		•  2.87169826684641 bayes_pls_golite062009
  • ATPase regulator activity
    		•  2.31076586548557 bayes_pls_golite062009
  • binding
    		•  2.05200237600398 bayes_pls_golite062009
  • ATPase activator activity
    		•  1.99816875782377 bayes_pls_golite062009
  • protein binding
    		•  1.12549021331477 bayes_pls_golite062009
  • heat shock protein binding
    		•  0.87871487226722 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  1.44038379867996 bayes_pls_golite062009
  • hydrolase activity
    		•  0.271155119882887 bayes_pls_golite062009
  • protein binding
    		•  0.186935278553638 bayes_pls_golite062009
  • catalytic activity
    		•  0.0116392906163881 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle