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Protein Overview: PPT1

General Information:
Name(s) found: PPT1 / YGR123C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 513 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: protein amino acid dephosphorylation [IDALink to PubMed article][ISSLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: protein serine/threonine phosphatase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTPTAADRA KALERKNEGN VFVKEKHFLK AIEKYTEAID LDSTQSIYFS NRAFAHFKVD  60
   61 NFQSALNDCD EAIKLDPKNI KAYHRRALSC MALLEFKKAR KDLNVLLKAK PNDPAATKAL 120
  121 LTCDRFIREE RFRKAIGGAE NEAKISLCQT LNLSSFDANA DLANYEGPKL EFEQLYDDKN 180
  181 AFKGAKIKNM SQEFISKMVN DLFLKGKYLP KKYVAAIISH ADTLFRQEPS MVELENNSTP 240
  241 DVKISVCGDT HGQFYDVLNL FRKFGKVGPK HTYLFNGDFV DRGSWSCEVA LLFYCLKILH 300
  301 PNNFFLNRGN HESDNMNKIY GFEDECKYKY SQRIFNMFAQ SFESLPLATL INNDYLVMHG 360
  361 GLPSDPSATL SDFKNIDRFA QPPRDGAFME LLWADPQEAN GMGPSQRGLG HAFGPDITDR 420
  421 FLRNNKLRKI FRSHELRMGG VQFEQKGKLM TVFSAPNYCD SQGNLGGVIH VVPGHGILQA 480
  481 GRNDDQNLII ETFEAVEHPD IKPMAYSNGG FGL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AHA1 BUD3 CNS1 CPR6 DIG2 DNM1 DSF1, YNR073C FRT2 GPA2 HOM6 HSC82 HSP104 HSP82 MBB1 MRPL50 PAM1 PPT1 QNS1 RMD8 RTS1 SMT3 STI1 STP4 TDH1 UTP20 YBL104C
    View Details Gavin AC, et al. (2002) HSC82 HSP82 PPT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SCH9 PPT1 2 Unpublished Fields Lab Data
    View Screen PPT1 ADR1 2 Uetz P, et al. (2000)
    View Screen YLR076C PPT1 2 Unpublished Fields Lab Data
    View Screen PPT1 ACA1 2 Unpublished Fields Lab Data
    View Screen PLB1 PPT1 2 Unpublished Fields Lab Data
    View Screen PPT1 YNL011C 2 Unpublished Fields Lab Data
    View Screen PPG1 PPT1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PPT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..44] PSI-BLAST 262.440336 Protein phosphatase 5
    2 View Details [45..166] PSI-BLAST 262.440336 Protein phosphatase 5
    3 View Details [167..513] PSI-BLAST 628.0 Protein phosphatase-1 (PP-1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  6.04386346716682 bayes_pls_golite062009
  • hydrolase activity
    		•  4.67522104695122 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  4.20017318089013 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36571535004008 bayes_pls_golite062009
  • DNA binding
    		•  1.71381351716702 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.61516860680687 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transcription factor activity
    		•  1.01338808398786 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • transcription factor binding
    		•  0.518146612491969 bayes_pls_golite062009
  • signal transducer activity
    		•  0.474250625448338 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.474250625448338 bayes_pls_golite062009
  • structural molecule activity
    		•  0.364610105488011 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30464889749774 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0593768116971065 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle