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Protein Overview: UBR1

General Information:
Name(s) found: UBR1 / YGR184C [SGD]
Description(s) found:
Found 30 descriptions.
SHOW ALL
  • E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1950 amino acids

    Gene Ontology:
    Cellular Component: proteasome complex [IPILink to PubMed article]
    Biological Process: protein polyubiquitination [TASLink to PubMed article]
    protein monoubiquitination [TASLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVADDDLGS LQGHIRRTLR SIHNLPYFRY TRGPTERADM SRALKEFIYR YLYFVISNSG  60
   61 ENLPTLFNAH PKQKLSNPEL TVFPDSLEDA VDIDKITSQQ TIPFYKIDES RIGDVHKHTG 120
  121 RNCGRKFKIG EPLYRCHECG CDDTCVLCIH CFNPKDHVNH HVCTDICTEF TSGICDCGDE 180
  181 EAWNSPLHCK AEEQENDISE DPATNADIKE EDVWNDSVNI ALVELVLAEV FDYFIDVFNQ 240
  241 NIEPLPTIQK DITIKLREMT QQGKMYERAQ FLNDLKYEND YMFDGTTTAK TSPSNSPEAS 300
  301 PSLAKIDPEN YTVIIYNDEY HNYSQATTAL RQGVPDNVHI DLLTSRIDGE GRAMLKCSQD 360
  361 LSSVLGGFFA VQTNGLSATL TSWSEYLHQE TCKYIILWIT HCLNIPNSSF QTTFRNMMGK 420
  421 TLCSEYLNAT ECRDMTPVVE KYFSNKFDKN DPYRYIDLSI LADGNQIPLG HHKILPESST 480
  481 HSLSPLINDV ETPTSRTYSN TRLQHILYFD NRYWKRLRKD IQNVIIPTLA SSNLYKPIFC 540
  541 QQVVEIFNHI TRSVAYMDRE PQLTAIRECV VQLFTCPTNA KNIFENQSFL DIVWSIIDIF 600
  601 KEFCKVEGGV LIWQRVQKSN LTKSYSISFK QGLYTVETLL SKVHDPNIPL RPKEIISLLT 660
  661 LCKLFNGAWK IKRKEGEHVL HEDQNFISYL EYTTSIYSII QTAEKVSEKS KDSIDSKLFL 720
  721 NAIRIISSFL GNRSLTYKLI YDSHEVIKFS VSHERVAFMN PLQTMLSFLI EKVSLKDAYE 780
  781 ALEDCSDFLK ISDFSLRSVV LCSQIDVGFW VRNGMSVLHQ ASYYKNNPEL GSYSRDIHLN 840
  841 QLAILWERDD IPRIIYNILD RWELLDWFTG EVDYQHTVYE DKISFIIQQF IAFIYQILTE 900
  901 RQYFKTFSSL KDRRMDQIKN SIIYNLYMKP LSYSKLLRSV PDYLTEDTTE FDEALEEVSV 960
  961 FVEPKGLADN GVFKLKASLY AKVDPLKLLN LENEFESSAT IIKSHLAKDK DEIAKVVLIP1020
 1021 QVSIKQLDKD ALNLGAFTRN TVFAKVVYKL LQVCLDMEDS TFLNELLHLV HGIFRDDELI1080
 1081 NGKDSIPEAY LSKPICNLLL SIANAKSDVF SESIVRKADY LLEKMIMKKP NELFESLIAS1140
 1141 FGNQYVNDYK DKKLRQGVNL QETEKERKRR LAKKHQARLL AKFNNQQTKF MKEHESEFDE1200
 1201 QDNDVDMVGE KVYESEDFTC ALCQDSSSTD FFVIPAYHDH SPIFRPGNIF NPNEFMPMWD1260
 1261 GFYNDDEKQA YIDDDVLEAL KENGSCGSRK VFVSCNHHIH HNCFKRYVQK KRFSSNAFIC1320
 1321 PLCQTFSNCT LPLCQTSKAN TGLSLDMFLE SELSLDTLSR LFKPFTEENY RTINSIFSLM1380
 1381 ISQCQGFDKA VRKRANFSHK DVSLILSVHW ANTISMLEIA SRLEKPYSIS FFRSREQKYK1440
 1441 TLKNILVCIM LFTFVIGKPS MEFEPYPQQP DTVWNQNQLF QYIVRSALFS PVSLRQTVTE1500
 1501 ALTTFSRQFL RDFLQGLSDA EQVTKLYAKA SKIGDVLKVS EQMLFALRTI SDVRMEGLDS1560
 1561 ESIIYDLAYT FLLKSLLPTI RRCLVFIKVL HELVKDSENE TLVINGHEVE EELEFEDTAE1620
 1621 FVNKALKMIT EKESLVDLLT TQESIVSHPY LENIPYEYCG IIKLIDLSKY LNTYVTQSKE1680
 1681 IKLREERSQH MKNADNRLDF KICLTCGVKV HLRADRHEMT KHLNKNCFKP FGAFLMPNSS1740
 1741 EVCLHLTQPP SNIFISAPYL NSHGEVGRNA MRRGDLTTLN LKRYEHLNRL WINNEIPGYI1800
 1801 SRVMGDEFRV TILSNGFLFA FNREPRPRRI PPTDEDDEDM EEGEDGFFTE GNDEMDVDDE1860
 1861 TGQAANLFGV GAEGIAGGGV RDFFQFFENF RNTLQPQGNG DDDAPQNPPP ILQFLGPQFD1920
 1921 GATIIRNTNP RNLDEDDSDD NDDSDEREIW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AHA1 AHP1 ARF1 CCR4 CCT2 CCT3 CCT5 CCT6 CDC36 CDC39 COP1 CYS4 DCS1 DCS2 FZO1 GDB1 GFA1 GND1 GPG1 GSY1 HEF3 HTB1 LHS1 MGE1 MGT1 MYO2 NEW1 NUG1 PEX7 PIL1 POP2 RAD50 RFC4 RIP1 RNQ1 RPN6 RVB1 SEC27 SMC3 SOF1 STI1 TMA19 TSA2 UBP15 UBR1 URA7 VPS1 YAK1 YGL081W YHR033W YLR241W YPL247C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 sample 3121 run on DecaLCQ: searched for phosphorylation Green EM, et al (2005)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..75] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [76..205] Pfam 35.853872 Putative zinc finger in N-recognin No confident structure predictions are available.
    3 View Details [206..684] deduced N/A No confident structure predictions are available.
    4 View Details [685..1257] MSA 2.0159 View MSA. No confident structure predictions are available.
    5 View Details [1258..1556] deduced N/A No confident structure predictions are available.
    6 View Details [1557..1826] MSA 5.00995 View MSA. No confident structure predictions are available.
    7 View Details [1827..1950] deduced N/A No confident structure predictions are available.
    8 View Details [871..1009] FFAS03 2.35 No description for 2doaA was found.
    9 View Details [1010..1156] deduced N/A No confident structure predictions are available.
    10 View Details [1157..1327] MSA 2.060995 View MSA. No confident structure predictions are available.
    11 View Details [1328..1554] deduced N/A No confident structure predictions are available.
    12 View Details [1555..1654] MSA 1.044991 View MSA. No confident structure predictions are available.
    13 View Details [1655..1805] MSA 3.049987 View MSA. No confident structure predictions are available.
    14 View Details [1806..1950] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • hydrolase activity
    		•  2.37143167527915 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.23450316335876 bayes_pls_golite062009
  • binding
    		•  2.14387047687719 bayes_pls_golite062009
  • DNA binding
    		•  2.04297552772596 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.02735936435983 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.96945784119904 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.76884421390271 bayes_pls_golite062009
  • transcription factor activity
    		•  1.26194702122873 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.24657793410496 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.95341825085177 bayes_pls_golite062009
  • protein binding
    		•  0.863483803868456 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.111186019165274 bayes_pls_golite062009
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.
    13 No functions predicted.
    14 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle