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Protein Overview: NEW1

General Information:
Name(s) found: NEW1 / YPL226W [SGD]
Description(s) found:
Found 24 descriptions.
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  • ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1196 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: ATPase activity [ISSLink to PubMed article]
    ATP binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPKKFKDLN SFLDDQPKDP NLVASPFGGY FKNPAADAGS NNASKKSSYQ QQRNWKQGGN  60
   61 YQQGGYQSYN SNYNNYNNYN NYNNYNNYNN YNKYNGQGYQ KSTYKQSAVT PNQSGTPTPS 120
  121 ASTTSLTSLN EKLSNLELTP ISQFLSKIPE CQSITDCKNQ IKLIIEEFGK EGNSTGEKIE 180
  181 EWKIVDVLSK FIKPKNPSLV RESAMLIISN IAQFFSGKPP QEAYLLPFFN VALDCISDKE 240
  241 NTVKRAAQHA IDSLLNCFPM EALTCFVLPT ILDYLSSGAK WQAKMAALSV VDRIREDSAN 300
  301 DLLELTFKDA VPVLTDVATD FKPELAKQGY KTLLDYVSIL DNLDLSPRYK LIVDTLQDPS 360
  361 KVPESVKSLS SVTFVAEVTE PSLSLLVPIL NRSLNLSSSS QEQLRQTVIV VENLTRLVNN 420
  421 RNEIESFIPL LLPGIQKVVD TASLPEVREL AEKALNVLKE DDEADKENKF SGRLTLEEGR 480
  481 DFLLDHLKDI KADDSCFVKP YMNDETVIKY MSKILTVDSN VNDWKRLEDF LTAVFGGSDS 540
  541 QREFVKQDFI HNLRALFYQE KERADEDEGI EIVNTDFSLA YGSRMLLNKT NLRLLKGHRY 600
  601 GLCGRNGAGK STLMRAIANG QLDGFPDKDT LRTCFVEHKL QGEEGDLDLV SFIALDEELQ 660
  661 STSREEIAAA LESVGFDEER RAQTVGSLSG GWKMKLELAR AMLQKADILL LDEPTNHLDV 720
  721 SNVKWLEEYL LEHTDITSLI VSHDSGFLDT VCTDIIHYEN KKLAYYKGNL AAFVEQKPEA 780
  781 KSYYTLTDSN AQMRFPPPGI LTGVKSNTRA VAKMTDVTFS YPGAQKPSLS HVSCSLSLSS 840
  841 RVACLGPNGA GKSTLIKLLT GELVPNEGKV EKHPNLRIGY IAQHALQHVN EHKEKTANQY 900
  901 LQWRYQFGDD REVLLKESRK ISEDEKEMMT KEIDIDDGRG KRAIEAIVGR QKLKKSFQYE 960
  961 VKWKYWKPKY NSWVPKDVLV EHGFEKLVQK FDDHEASREG LGYRELIPSV ITKHFEDVGL1020
 1021 DSEIANHTPL GSLSGGQLVK VVIAGAMWNN PHLLVLDEPT NYLDRDSLGA LAVAIRDWSG1080
 1081 GVVMISHNNE FVGALCPEQW IVENGKMVQK GSAQVDQSKF EDGGNADAVG LKASNLAKPS1140
 1141 VDDDDSPANI KVKQRKKRLT RNEKKLQAER RRLRYIEWLS SPKGTPKPVD TDDEED

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HFM1 LYS4 NEW1 RBG1 SGD1 SOK1 SSZ1 TCB1 TGL5 TMA46 YEF3 YLR072W ZUO1
    View Details Gavin AC, et al. (2006) ALD6 GSH1 GSP2 IDH2 NEW1
    View Details Gavin AC, et al. (2002) CAM1 EFB1 FAP1 GFA1 GUS1 ILV1 KAP123 MGA2 NEW1 OLA1 SBP1 SEC27 TEF1, TEF2 TEF4
    View Details Ho Y, et al. (2002) CCT2 CCT3 CCT5 CCT6 FZO1 MYO2 NEW1 PEX7 RPN6 UBR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NEW1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..172] MSA 1.018941 View MSA. No confident structure predictions are available.
    2 View Details [173..280] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [281..427] PSI-BLAST 6.09691 Crystal structure of the P. furiosus Rad50 ATPase domain
    4 View Details [428..498] PSI-BLAST 6.09691 Crystal structure of the P. furiosus Rad50 ATPase domain
    5 View Details [499..564] deduced N/A No confident structure predictions are available.
    6 View Details [565..767] PSI-BLAST 118.045757 Glucose transport protein GlcV, N-terminal domain
    7 View Details [768..1033] PSI-BLAST 93.679424 MsbA
    8 View Details [1034..1196] MSA 2.692976 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle