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Protein Overview: PEX7

General Information:
Name(s) found: PEX7 / YDR142C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 375 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    peroxisomal matrix [IDALink to PubMed article][TAS]
    Biological Process: protein targeting to peroxisome [IMPLink to PubMed article][TASLink to PubMed article]
    peroxisome organization [TAS]
    Molecular Function: peroxisome matrix targeting signal-2 binding [IPILink to PubMed article]
    peroxisome targeting sequence binding [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRYHMQGFS GYGVQYSPFF DNRLAVAAGS NFGLVGNGKL FILEIDRSGR IVEVNSFLTQ  60
   61 DCLFDLAWNE SHENQVLVAQ GDGTLRLFDT TFKEFPIAIF KEHEREVFSC NWNLVNRQNF 120
  121 LSSSWDGSIK IWSPLRKQSL MTLTPRPLEI TKMVDPLNAI ILKKKSFTGI SKNRNCVYQA 180
  181 QFSPHDQNLV LSCSGNSYAS LFDIRLPSGK NQNNFLVHSG LEALTCDFNK YRPYVVATGG 240
  241 VDNAIRIWDI RMLNKNESAT IKRTVPGQLH NSSCINEIPN AHGLAIRKVT WSPHHSNILM 300
  301 SASYDMTCRI WRDLSNDGAK ETYKTNSTDA TKGSIFNFTQ HSEFVFGADW SLWGKPGYVA 360
  361 STAWDGNLFV WNGLG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Hazbun TR, et al. (2003) HOL1 MMP1 PEX7 PLB1 YJR012C
    View Details Krogan NJ, et al. (2006) PEX7 YJR012C
    View Details Ho Y, et al. (2002) CCT2 CCT3 CCT5 CCT6 FZO1 LAP4 MYO2 NEW1 PEX7 RPN6 SEC6 SEN2 UBR1
    View Details Qiu et al. (2008) INP2 PEX13 PEX7 PEX8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YJR012C No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..375] PSI-BLAST 58.0 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peroxisome targeting sequence binding
    		•  2.43196533618619 bayes_pls_golite062009
  • binding
    		•  2.2778252170547 bayes_pls_golite062009
  • peroxisome matrix targeting signal-2 binding
    		•  1.26984584070766 bayes_pls_golite062009
  • protein binding
    		•  1.24173112731149 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.520265606469501 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.518364053507325 bayes_pls_golite062009
    		• 0.45054027253231 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.359536347486199 bayes_pls_golite062009
  • snoRNA binding
    		•  0.283655461357951 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.261490211382488 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle