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Protein Overview: GSH1

General Information:
Name(s) found: GSH1 / YJL101C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 678 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IDALink to PubMed article]
    Biological Process: response to hydrogen peroxide [IEPLink to PubMed article][IMPLink to PubMed article]
    response to heat [IEPLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    glutathione biosynthetic process [IDALink to PubMed article][IMPLink to PubMed article]
    response to cold [IEPLink to PubMed article]
    response to mercury ion [IEPLink to PubMed article]
    response to cadmium ion [IDALink to PubMed article][IEPLink to PubMed article]
    Molecular Function: glutamate-cysteine ligase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [NCBI BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLLALGTPL QWFESRTYNE HIRDEGIEQL LYIFQAAGKR DNDPLFWGDE LEYMVVDFDD  60
   61 KERNSMLDVC HDKILTELNM EDSSLCEAND VSFHPEYGRY MLEATPASPY LNYVGSYVEV 120
  121 NMQKRRAIAE YKLSEYARQD SKNNLHVGSR SVPLTLTVFP RMGCPDFINI KDPWNHKNAA 180
  181 SRSLFLPDEV INRHVRFPNL TASIRTRRGE KVCMNVPMYK DIATPETDDS IYDRDWFLPE 240
  241 DKEAKLASKP GFIYMDSMGF GMGCSCLQVT FQAPNINKAR YLYDALVNFA PIMLAFSAAA 300
  301 PAFKGWLADQ DVRWNVISGA VDDRTPKERG VAPLLPKYNK NGFGGIAKDV QDKVLEIPKS 360
  361 RYSSVDLFLG GSKFFNRTYN DTNVPINEKV LGRLLENDKA PLDYDLAKHF AHLYIRDPVS 420
  421 TFEELLNQDN KTSSNHFENI QSTNWQTLRF KPPTQQATPD KKDSPGWRVE FRPFEVQLLD 480
  481 FENAAYSVLI YLIVDSILTF SDNINAYIHM SKVWENMKIA HHRDAILFEK FHWKKSFRND 540
  541 TDVETEDYSI SEIFHNPENG IFPQFVTPIL CQKGFVTKDW KELKHSSKHE RLYYYLKLIS 600
  601 DRASGELPTT AKFFRNFVLQ HPDYKHDSKI SKSINYDLLS TCDRLTHLDD SKGELTSFLG 660
  661 AEIAEYVKKN KPSIESKC

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) ALD6 GSH1 GSP2 IDH2 NEW1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GSH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?] [View Top Sequence Alignments]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..237] MSA 2.013924 View MSA. No confident structure predictions are available.
    2 View Details [238..678] Pfam 300.721246 Glutamate-cysteine ligase No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by:     Michael Riffle