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Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein. Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. Catalysis of the reaction IAA + an amino acid = an IAA amide conjugate. Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. Catalysis of the reaction: 4 ATP + citrate + N6-acetyl-N6-hydroxylysine = 4 ADP + 4 phosphate + aerobactin. Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate. Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. Catalysis of the reaction: L-2-aminohexanedioate + L-cysteine + L-valine + 3 ATP + H2O = N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate. Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine. Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives. Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine. Catalysis of the reaction: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate. Catalysis of the reaction: ATP + L-tyrosine + L-arginine = AMP + diphosphate + L-tyrosyl-L-arginine. Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein. Catalysis of the reaction: (Z)-phenylacetaldehyde oxime = phenylacetonitrile + H2O. Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + beta-alanine = ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine. Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine. Catalyzes the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates, i.e. GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1 followed by GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate. Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O. Catalysis of the reaction: jasmonate (JA) + an amino acid (including non-standard amino acids, such as ACC (1-aminocyclopropane-1-carboxylate)) = a jasmonyl-amino acid (amide-linked) conjugate. Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid. Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown. Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine + ATP = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ADP. Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP. Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer). Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP. Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: acid-amino acid ligase activity
Acc: GO:0016881
Aspect: Molecular Function
Desc: Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.
Synonyms:
  • peptide synthase activity
Proteins in PDR annotated with:
   This term: 88 [Search]
   Term or descendants: 1289 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016881 - acid-amino acid ligase activity (interactive image map)
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