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Catalysis of the covalent attachment of the ubiquitin-like protein UFM1 to other proteins or other substrate molecules. Catalysis of the covalent attachment of the ubiquitin-like protein FAT10 to other proteins. Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue. Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal glycine residues of the small ubiquitin-related modifier SUMO and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function. Catalysis of the covalent attachment of the ubiquitin-like protein Atg12 to other proteins. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the covalent attachment of the ubiquitin-like protein URM1 to other proteins or other substrate molecules. Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: small conjugating protein ligase activity
Acc: GO:0019787
Aspect: Molecular Function
Desc: Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase.
Synonyms:
  • GO:0008639
  • small protein conjugating enzyme activity
  • ubiquitin-like-protein ligase activity
  • ubiquitin-like conjugating enzyme activity
  • GO:0008640
  • E2
Proteins in PDR annotated with:
   This term: 173 [Search]
   Term or descendants: 986 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0019787 - small conjugating protein ligase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle