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Protein Overview: VPS1

General Information:
Name(s) found: VPS1 / YKR001C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 704 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    peroxisome [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed article]
    Biological Process: protein retention in Golgi apparatus [IMPLink to PubMed article]
    peroxisome organization [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    vacuolar transport [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    actin cytoskeleton organization [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: GTPase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEHLISTIN KLQDALAPLG GGSQSPIDLP QITVVGSQSS GKSSVLENIV GRDFLPRGTG  60
   61 IVTRRPLVLQ LINRRPKKSE HAKVNQTANE LIDLNINDDD KKKDESGKHQ NEGQSEDNKE 120
  121 EWGEFLHLPG KKFYNFDEIR KEIVKETDKV TGANSGISSV PINLRIYSPH VLTLTLVDLP 180
  181 GLTKVPVGDQ PPDIERQIKD MLLKYISKPN AIILSVNAAN TDLANSDGLK LAREVDPEGT 240
  241 RTIGVLTKVD LMDQGTDVID ILAGRVIPLR YGYIPVINRG QKDIEHKKTI REALENERKF 300
  301 FENHPSYSSK AHYCGTPYLA KKLNSILLHH IRQTLPEIKA KIEATLKKYQ NELINLGPET 360
  361 MDSASSVVLS MITDFSNEYA GILDGEAKEL SSQELSGGAR ISYVFHETFK NGVDSLDPFD 420
  421 QIKDSDIRTI MYNSSGSAPS LFVGTEAFEV LVKQQIRRFE EPSLRLVTLV FDELVRMLKQ 480
  481 IISQPKYSRY PALREAISNQ FIQFLKDATI PTNEFVVDII KAEQTYINTA HPDLLKGSQA 540
  541 MVMVEEKLHP RQVAVDPKTG KPLPTQPSSS KAPVMEEKSG FFGGFFSTKN KKKLAALESP 600
  601 PPVLKATGQM TERETMETEV IKLLISSYFS IVKRTIADII PKALMLKLIV KSKTDIQKVL 660
  661 LEKLYGKQDI EELTKENDIT IQRRKECKKM VEILRNASQI VSSV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARP9 HHF1, HHF2 IOC3 ISW1 ISW2 ITC1 KAP114 MOT1 NPL6 RFA1 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 SPT15 STH1 TAF1 TAF5 VPS1
    View Details Krogan NJ, et al. (2006) CYB5 ETR1 NOT3 RPL40B, RPL40A VMA5 VPS1 YPT1
    View Details Gavin AC, et al. (2006) ABF2 VPS1
    View Details Gavin AC, et al. (2002) ABF2 ACT1 ADA2 ADE5,7 ADH1 ARP4 ARP8 ARP9 AVO1 BEM2 CAB3 CEG1 CET1 CHD1 CKA1 CKA2 CKB1 CKB2 CLU1 CMR1 CTI6 CTR9 DEP1 DIM1 DNA2 DOT6 DPB2 DPB4 EAF3 ECM16 ENP1 ESC8 FUN19 GCN1 GCN5 HDA1 HDA2 HDA3 HEM13 HHF1, HHF2 HOT1 HRR25 HSC82 HTA2 IES1 IES5 INO80 IOC3 ISW1 ISW2 ITC1 KAP114 KAP123 KAP95 LCD1 LSM12 LTV1 MEC1 MED4 MES1 MGM101 MIR1 MLH1 MNN4 MOT1 MPH1 MSH2 MSH3 MSH6 MYO1 NAP1 NGG1 NHP10 NIP1 NOB1 NOP1 NPL6 NRD1 OLA1 PDB1 PDC1 PEP4 PFK2 PGK1 PHO23 PMS1 PNO1 POL2 PRO2 PRP43 PRT1 PSK1 PTC1 PUF6 RAD16 RAD52 RCO1 REB1 RET1 RFA1 RFA2 RFA3 RFX1 RIM1 RIO2 RNH1 RNR2 RPA135 RPB2 RPC34 RPC40 RPC82 RPD3 RPG1 RPN9 RPO21 RPO31 RPT5 RRP12 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RVB2 RXT2 RXT3 SAP30 SDS3 SFH1 SGF29 SGF73 SGS1 SHS1 SIN3 SIN4 SNF12 SNF2 SNF5 SNF6 SPT15 SPT16 SPT20 SPT7 SPT8 SSA3 SSA4 STH1 STO1 SWI1 SWI3 SWP82 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TDH3 TEF4 TFC7 TIF1, TIF2 TIF35 TOP1 TOP2 TOP3 TSR1 TUP1 UME1 UME6 UTP22 VAS1 VMA4 VPS1 WRS1 YBR090C-A, NHP6B YEF3 YGR054W YHR122W YMR315W YTA7
    View Details Ho Y, et al. (2002) AHP1 CDC39 DCS1 DCS2 DNM1 GDB1 RAD50 TSA2 UBP15 UBR1 VPS1 YAK1 YLR241W YPL247C
    View Details Qiu et al. (2008) ARL1 RHO1 VPS1 YPT7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VPS1 and SNF7 Huh WK, et al. (2003)
    View Data VPS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..356] PSI-BLAST 1185.0 Dynamin G domain
    2 View Details [357..583] Pfam 42.69897 Dynamin central region No confident structure predictions are available.
    3 View Details [584..704] Pfam 40.173925 Dynamin GTPase effector domain No confident structure predictions are available.
    4 View Details [600..704] Pfam 40.187087 No description for PF02212.9 was found. Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.74389108884083 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.67097555143215 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.65161658635465 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.64849912301318 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.39629638016861 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.39600931083427 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.36051733655256 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.35906629925754 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.35679406876731 bayes_pls_golite062009
  • ATPase activity
    		•  2.2625504298178 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.24901251684901 bayes_pls_golite062009
  • binding
    		•  2.01755875920323 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.65609907941094 bayes_pls_golite062009
  • motor activity
    		•  1.47133910026814 bayes_pls_golite062009
  • protein transporter activity
    		•  1.37245678118001 bayes_pls_golite062009
  • hydrolase activity
    		•  1.34710139310747 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.3182108176243 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.723407201613229 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.704934361725919 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.568484017802328 bayes_pls_golite062009
  • actin binding
    		•  0.563996324417607 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.46552249844591 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • signal recognition particle binding
    		•  0.29390189699022 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.282397764628576 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0636334376764289 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.0529006651532686 bayes_pls_golite062009
  • signal transducer activity
    		•  0.0529006651532686 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle