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Protein Overview: SGF73

General Information:
Name(s) found: SGF73 / YGL066W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters; null mutant displays defects in premeiotic DNA synthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 657 amino acids

    Gene Ontology:
    Cellular Component: SLIK (SAGA-like) complex [IPILink to PubMed article]
    SAGA complex [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    Biological Process: chromatin modification [IMPLink to PubMed articleLink to PubMed article]
    histone acetylation [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: histone acetyltransferase activity [IMPLink to PubMed article]
    structural molecule activity [IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSGDAEIKG IKPKVIEEYS LSQGSGPSND SWKSLMSSAK DTPLQYDHMN RESLKKYFNP  60
   61 NAQLIEDPLD KPIQYRVCEK CGKPLALTAI VDHLENHCAG ASGKSSTDPR DESTRETIRN 120
  121 GVESTGRNNN DDDNSNDNNN DDDDDDDNDD NEDDDDADDD DDNSNGANYK KNDSSFNPLK 180
  181 RSTSMESANT PNMDTKRSKT GTPQTFSSSI KKQKKVKQRN PTEKHLIDFN KQCGVELPEG 240
  241 GYCARSLTCK SHSMGAKRAV SGRSKPYDVL LADYHREHQT KIGAAAEKRA KQQELQKLQK 300
  301 QIQKEQKKHT QQQKQGQRSK QRNVNGGKSA KNGGKSTVHN GNNINEIGHV NLTPEEETTQ 360
  361 VLNGVSRSFP LPLESTVLSS VRYRTKYFRM REMFASSFSV KPGYTSPGYG AIHSRVGCLD 420
  421 LDRTTDYKFR VRTPQPINHL TNQNLNPKQI QRLQQQRALQ AQLLSQQQQQ QQQQQQHHSP 480
  481 QAQAQASTQQ PTQGMVPNHF PGGATNSSFN ANVSSKQIQQ QQQQQQHKSQ DTGLTPLEIQ 540
  541 SQQQKLRQQQ LQQQKFEAAA SYLANATKLM QESNQDSHLS GTHNNNSSKN GNNNLMTMKA 600
  601 SISSPNTSVN SIQSPPSVNS VNGSGQGVST GINVSGNNGR IEVGIGNSVN PYNGRIN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADA2 GCN5 HFI1 NGG1 SGF11 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 TRA1 UBP8
    View Details (MIPS) Mewes HW, et al. (2004) ADA2 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF10 TAF12 TAF5 TAF6 TAF9 TRA1
    View Details Krogan NJ, et al. (2006) ADA2 AHC1 AHC2 FMP40 GCN5 HFI1 MSS4 NGG1 PDR15 RAD59 REV3 SGF11 SGF29 SGF73 SNL1 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 UBP8 YMR007W
    View Details Gavin AC, et al. (2006) ADA2 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8
    View Details Gavin AC, et al. (2002) ADA2 ADH1 CLU1 FUN19 GCN5 HEM13 HFI1 KAP114 KAP123 MED4 MES1 MNN4 MOT1 MYO1 MYO4 NGG1 NOP1 PFK2 PSK1 PTC1 PUF6 RPB2 RPN9 RPO21 RPT5 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 UBP8 VAS1 VPS1
    View Details Qiu et al. (2008) ADA2 AHC1 ARP4 CHD1 EAF3 EPL1 GAL11 GCN5 HFI1 MED1 MED2 MED6 NGG1 NUT1 NUT2 PGD1 RGR1 SAS3 SGF11 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 SRB2 SRB4 SRB5 SRB6 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF5 TAF6 TAF8 TAF9 TRA1 UBP8 YNG1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SGF73 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] ORFEUS 10.1 No description for 1l8mA was found.
    2 View Details [111..189] ORFEUS 10.1 No description for 1l8mA was found.
    3 View Details [190..258] ORFEUS 10.1 No description for 1l8mA was found.
    4 View Details [259..332] ORFEUS 10.1 No description for 1l8mA was found.
    5 View Details [333..657] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle