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Protein Overview: SIN3

General Information:
Name(s) found: SIN3 / YOL004W [SGD]
Description(s) found:
Found 23 descriptions.
SHOW ALL
  • Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1536 amino acids

    Gene Ontology:
    Cellular Component: Sin3 complex [IPILink to PubMed article]
    histone deacetylase complex [IPILink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed articleLink to PubMed article]
    chromatin silencing at rDNA [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    double-strand break repair via nonhomologous end joining [IMPLink to PubMed article]
    histone deacetylation [IMPLink to PubMed article]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed articleLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    Molecular Function: transcription coactivator activity [IMPLink to PubMed article]
    histone deacetylase activity [IMPLink to PubMed article]
    transcription corepressor activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQVWHNSNS QSNDVATSND ATGSNERNEK EPSLQGNKPG FVQQQQRITL PSLSALSTKE  60
   61 EDRRDSNGQQ ALTSHAAHIL GYPPPHSNAM PSIATDSALK QPHEYHPRPK SSSSSPSINA 120
  121 SLMNAGPAPL PTVGAASFSL SRFDNPLPIK APVHTEEPKS YNGLQEEEKA TQRPQDCKEV 180
  181 PAGVQPADAP DPSSNHADAN DDNNNNENSH DEDADYRPLN VKDALSYLEQ VKFQFSSRPD 240
  241 IYNLFLDIMK DFKSQAIDTP GVIERVSTLF RGYPILIQGF NTFLPQGYRI ECSSNPDDPI 300
  301 RVTTPMGTTT VNNNISPSGR GTTDAQELGS FPESDGNGVQ QPSNVPMVPS SVYQSEQNQD 360
  361 QQQSLPLLAT SSGLPSIQQP EMPAHRQIPQ SQSLVPQEDA KKNVDVEFSQ AISYVNKIKT 420
  421 RFADQPDIYK HFLEILQTYQ REQKPINEVY AQVTHLFQNA PDLLEDFKKF LPDSSASANQ 480
  481 QVQHAQQHAQ QQHEAQMHAQ AQAQAQAQAQ VEQQKQQQQF LYPASGYYGH PSNRGIPQQN 540
  541 LPPIGSFSPP TNGSTVHEAY QDQQHMQPPH FMPLPSIVQH GPNMVHQGIA NENPPLSDLR 600
  601 TSLTEQYAPS SIQHQQQHPQ SISPIANTQY GDIPVRPEID LDPSIVPVVP EPTEPIENNI 660
  661 SLNEEVTFFE KAKRYIGNKH LYTEFLKILN LYSQDILDLD DLVEKVDFYL GSNKELFTWF 720
  721 KNFVGYQEKT KCIENIVHEK HRLDLDLCEA FGPSYKRLPK SDTFMPCSGR DDMCWEVLND 780
  781 EWVGHPVWAS EDSGFIAHRK NQYEETLFKI EEERHEYDFY IESNLRTIQC LETIVNKIEN 840
  841 MTENEKANFK LPPGLGHTSM TIYKKVIRKV YDKERGFEII DALHEHPAVT APVVLKRLKQ 900
  901 KDEEWRRAQR EWNKVWRELE QKVFFKSLDH LGLTFKQADK KLLTTKQLIS EISSIKVDQT 960
  961 NKKIHWLTPK PKSQLDFDFP DKNIFYDILC LADTFITHTT AYSNPDKERL KDLLKYFISL1020
 1021 FFSISFEKIE ESLYSHKQNV SESSGSDDGS SIASRKRPYQ QEMSLLDILH RSRYQKLKRS1080
 1081 NDEDGKVPQL SEPPEEEPNT IEEEELIDEE AKNPWLTGNL VEEANSQGII QNRSIFNLFA1140
 1141 NTNIYIFFRH WTTIYERLLE IKQMNERVTK EINTRSTVTF AKDLDLLSSQ LSEMGLDFVG1200
 1201 EDAYKQVLRL SRRLINGDLE HQWFEESLRQ AYNNKAFKLY TIDKVTQSLV KHAHTLMTDA1260
 1261 KTAEIMALFV KDRNASTTSA KDQIIYRLQV RSHMSNTENM FRIEFDKRTL HVSIQYIALD1320
 1321 DLTLKEPKAD EDKWKYYVTS YALPHPTEGI PHEKLKIPFL ERLIEFGQDI DGTEVDEEFS1380
 1381 PEGISVSTLK IKIQPITYQL HIENGSYDVF TRKATNKYPT IANDNTQKGM VSQKKELISK1440
 1441 FLDCAVGLRN NLDEAQKLSM QKKWENLKDS IAKTSAGNQG IESETEKGKI TKQEQSDNLD1500
 1501 SSTASVLPAS ITTVPQDDNI ETTGNTESSD KGAKIQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CTI6 DEP1 EAF3 FUN19 PHO23 RCO1 RPD3 RXT2 RXT3 SAP30 SDS3 SIN3 UME1
    View Details (MIPS) Mewes HW, et al. (2004) RPD3 SAP30 SIN3 STB1 STB2
    View Details Krogan NJ, et al. (2006) ASH1 COQ6 CTI6 DEP1 EAF3 GRX5 PHO23 RCO1 RPD3 RXT2 RXT3 SAP30 SAY1 SDS3 SIN3 UME1
    View Details Gavin AC, et al. (2006) CTI6 RCO1 RPD3 RXT3 SAP30 SDS3 SIN3 UME1
    View Details Gavin AC, et al. (2002) ABF2 ACT1 ADA2 ADH1 ARP4 ARP8 ATG3 CDC45 CKA1 CKA2 CKB1 CKB2 CLU1 CTI6 DEP1 DOT6 EAF3 ECM16 ERG26 ESC8 FUN19 GCN1 GCN5 GLT1 HAT1 HEM13 HSP42 HTA2 IES1 IES5 INO80 IOC3 ISW1 ISW2 ITC1 KAP114 KAP123 LYS12 MCM2 MCM5 MCM6 MCM7 MED4 MES1 MNN4 MOT1 MTR10 MYO1 NGG1 NHP10 NOP1 NPL6 NRD1 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PDC1 PFK2 PHO23 PSK1 PTC1 PUF6 RCO1 RPB2 RPC40 RPD3 RPN9 RPO21 RPT5 RSC2 RSC4 RSC58 RSC6 RSC8 RVB2 RXT2 RXT3 SAP30 SDS3 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 STO1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 TFP1 TOP1 TUP1 UME1 UME6 VAS1 VPS1
    View Details Ho Y, et al. (2002) ADH2 CDC28 CEG1 CKA1 CKA2 CKB1 CKB2 CTI6 DIS3 EAF3 FIP1 FKH1 FKH2 FYV8 GCD2 GCD7 GCN3 HAS1 HHF1, HHF2 HPR1 HTB1 HTB2 INO80 KAP95 MBP1 MES1 MFT1 MGM101 MPH1 NAM8 NET1 NOP1 NOP6 NUP1 NUP2 NUP60 PAP1 PCT1 REB1 RNT1 RPD3 RRP1 RRP4 RRP43 RRP6 RTT103 SEC2 SIF2 SIN3 SNU56 SRP1 STO1 SUI2 SUI3 THO2 TRA1 UBP12 UME1 URE2 YGR017W YMR144W YPR090W
    View Details Qiu et al. (2008) HDA1 HDA2 HDA3 HOS1 SAP30 SDS3 SIN3 SNT1 STB2 SUM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SIN3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..237] ORFEUS 11.5 RBP1
    2 View Details [238..321] Pfam 19.346787 Paired amphipathic helix repeat No confident structure predictions are available.
    3 View Details [322..423] deduced N/A No confident structure predictions are available.
    4 View Details [424..489] Pfam 19.69897 Paired amphipathic helix repeat No confident structure predictions are available.
    5 View Details [490..606] PSI-BLAST 172.134302 Sin3A
    6 View Details [607..732] ORFEUS 11.33 Sin3A
    7 View Details [733..1024] MSA 1.021966 View MSA. No confident structure predictions are available.
    8 View Details [1025..1368] MSA 2.019929 View MSA. No confident structure predictions are available.
    9 View Details [1369..1536] MSA 2.014993 View MSA. No confident structure predictions are available.
    10 View Details [1179..1355] deduced N/A No confident structure predictions are available.
    11 View Details [1356..1449] deduced N/A No confident structure predictions are available.
    12 View Details [1450..1536] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein deacetylase activity
    		•  8.92489148049718 bayes_pls_golite062009
  • histone deacetylase activity
    		•  8.77562367748348 bayes_pls_golite062009
  • deacetylase activity
    		•  7.74805102638387 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.99241841178307 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  4.85992273034906 bayes_pls_golite062009
  • transcription repressor activity
    		•  4.25514230798992 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.82193713323077 bayes_pls_golite062009
  • transcription corepressor activity
    		•  3.30769773581294 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.83214064778422 bayes_pls_golite062009
  • DNA binding
    		•  2.82083682611814 bayes_pls_golite062009
  • transcription factor binding
    		•  2.73494763175272 bayes_pls_golite062009
  • transcription cofactor activity
    		•  2.59356984380124 bayes_pls_golite062009
  • binding
    		•  2.59005615358803 bayes_pls_golite062009
  • protein binding
    		•  2.41769888237582 bayes_pls_golite062009
  • transcription factor activity
    		•  1.99794029160509 bayes_pls_golite062009
  • transcription activator activity
    		•  1.89949115818087 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.41949477529902 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.918453145717461 bayes_pls_golite062009
  • catalytic activity
    		•  0.30211814650972 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • protein deacetylase activity
    		•  9.15317765173842 bayes_pls_golite062009
  • histone deacetylase activity
    		•  9.00540919224423 bayes_pls_golite062009
  • deacetylase activity
    		•  7.91874136549804 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  6.08470985892139 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  4.91057345050982 bayes_pls_golite062009
  • transcription repressor activity
    		•  4.58162229232685 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.97924147512738 bayes_pls_golite062009
  • transcription corepressor activity
    		•  3.71696410617503 bayes_pls_golite062009
  • transcription factor binding
    		•  3.06004981994503 bayes_pls_golite062009
  • transcription cofactor activity
    		•  2.96293930027313 bayes_pls_golite062009
  • DNA binding
    		•  2.90699688513784 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.89854237920034 bayes_pls_golite062009
  • binding
    		•  2.65480555250736 bayes_pls_golite062009
  • protein binding
    		•  2.51615225301602 bayes_pls_golite062009
  • transcription factor activity
    		•  2.07660852403223 bayes_pls_golite062009
  • transcription activator activity
    		•  1.96507140095887 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.50631346254518 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.06494495723884 bayes_pls_golite062009
  • catalytic activity
    		•  0.289349813503192 bayes_pls_golite062009
    6
    Term Confidence Notes
  • protein deacetylase activity
    		•  8.92489148049718 bayes_pls_golite062009
  • histone deacetylase activity
    		•  8.77562367748348 bayes_pls_golite062009
  • deacetylase activity
    		•  7.74805102638387 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.99241841178307 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  4.85992273034906 bayes_pls_golite062009
  • transcription repressor activity
    		•  4.25514230798992 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.82193713323077 bayes_pls_golite062009
  • transcription corepressor activity
    		•  3.30769773581294 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.83214064778422 bayes_pls_golite062009
  • DNA binding
    		•  2.82083682611814 bayes_pls_golite062009
  • transcription factor binding
    		•  2.73494763175272 bayes_pls_golite062009
  • transcription cofactor activity
    		•  2.59356984380124 bayes_pls_golite062009
  • binding
    		•  2.59005615358803 bayes_pls_golite062009
  • protein binding
    		•  2.41769888237582 bayes_pls_golite062009
  • transcription factor activity
    		•  1.99794029160509 bayes_pls_golite062009
  • transcription activator activity
    		•  1.89949115818087 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.41949477529902 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.918453145717461 bayes_pls_golite062009
  • catalytic activity
    		•  0.30211814650972 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle