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Protein Overview: HDA2

General Information:
Name(s) found: HDA2 / YDR295C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 674 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    histone deacetylase complex [IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IDALink to PubMed article]
    histone deacetylation [IDALink to PubMed article]
    Molecular Function: histone deacetylase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRKNSKKLK VYYLPVTLTQ FQKDLSEILI SLHAKSFKAS IIGEPQADAV NKPSGLPAGP  60
   61 ETHPYPTLSQ RQLTYIFDSN IRAIANHPSL LVDHYMPRQL LRMEPTESSI AGSHKFQVLN 120
  121 QLINSICFRD REGSPNEVIK CAIIAHSIKE LDLLEGLILG KKFRTKRLSG TSLYNEKHKF 180
  181 PNLPTVDSTI NKDGTPNSVS STSSNSNSTS YTGYSKDDYD YSVKRNLKKR KINTDDWLFL 240
  241 ATTKHLKHDQ YLLANYDIDM IISFDPMLEV ELPALQVLRN NANKDIPIIK LLVQNSPDHY 300
  301 LLDSEIKNSS VKSSHLSNNG HVDDSQEYEE IKSSLLYFLQ ARNAPVNNCE IDYIKLVKCC 360
  361 LEGKDCNNIL PVLDLITLDE ASKDSSDSGF WQPQLTKLQY SSTELPLWDG PLDIKTYQTE 420
  421 LMHRAVIRLR DIQDEYAKGT VPLYEKRLNE TQRQNQLDEI KNSVGLTFKK KQEVEKSIND 480
  481 SEKRLKHAMT ESTKLQNKIN HLLKNRQELE NFNKLPSNTI SSENHLEEGS ALADKLKEYI 540
  541 DKNATLFNKL KELQQANAEK SKLNDELRSK YQIESSKAAE SAQTLKILQE SMKSLENEVN 600
  601 GPLTKFSTES LKKELERLQN DFQSLKARNK FLKNYITLMN RQYDLKNKNN VQVEKAAANG 660
  661 TRFRSTRSNT PNYT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HDA1 HDA2 HDA3
    View Details Krogan NJ, et al. (2006) HDA1 HDA2 HDA3
    View Details Gavin AC, et al. (2006) HDA1 HDA2 HDA3 PRO2
    View Details Gavin AC, et al. (2002) CMR1 DNA2 HDA1 HDA2 HDA3 HSC82 KAP95 LCD1 MEC1 MGM101 MLH1 MPH1 MSH2 MSH3 MSH6 OLA1 PGK1 PMS1 PRO2 RAD16 RAD52 RFA1 RFA2 RFA3 RIM1 RNH1 RSC8 RVB2 SGS1 SHS1 TIF1, TIF2 TOP3 VAS1 VPS1 YHR122W
    View Details Qiu et al. (2008) HDA1 HDA2 HDA3 HOS1 HOS4 RPD3 SDS3 SET3 SIN3 SNT1 STB2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HDA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..59] deduced N/A No confident structure predictions are available.
    2 View Details [60..391] PSI-BLAST 17.154902 Heavy meromyosin subfragment
    3 View Details [392..498] PSI-BLAST 8.69897 Tropomyosin
    4 View Details [499..674] MSA 4.212997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein deacetylase activity
    		•  6.89067246450687 bayes_pls_golite062009
  • histone deacetylase activity
    		•  6.72973102400173 bayes_pls_golite062009
  • deacetylase activity
    		•  6.17788760083229 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.08778624990141 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  4.31765999651746 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.55154985983449 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.90369937566383 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.90369937566383 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.49423102874486 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.712553030350746 bayes_pls_golite062009
  • histone binding
    		•  0.557787598121402 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.474709214154094 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.141400887946529 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle