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Protein Overview: MSH3

General Information:
Name(s) found: MSH3 / YCR092C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1047 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: removal of nonhomologous ends [IGILink to PubMed article][IMPLink to PubMed article][TASLink to PubMed article]
    DNA recombination [IMPLink to PubMed article]
    meiotic mismatch repair [IMPLink to PubMed article]
    mismatch repair [IMPLink to PubMed articleLink to PubMed article]
    mitotic recombination [IMPLink to PubMed article]
    Molecular Function: double-strand/single-strand DNA junction binding [IDALink to PubMed article]
    DNA insertion or deletion binding [IDALink to PubMed article]
    loop DNA binding [IDALink to PubMed article]
    Y-form DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVIGNEPKLV LLRAKSSANR FILLNLLTIM AGQPTISRFF KKAVKSELTH KQEQEVAVGN  60
   61 GAGSESICLD TDEEDNLSSV ASTTVTNDSF PLKGSVSSKN SKNSEKTSGT STTFNDIDFA 120
  121 KKLDRIMKRR SDENVEAEDD EEEGEEDFVK KKARKSPTAK LTPLDKQVKD LKMHHRDKVL 180
  181 VIRVGYKYKC FAEDAVTVSR ILHIKLVPGK LTIDESNPQD CNHRQFAYCS FPDVRLNVHL 240
  241 ERLVHHNLKV AVVEQAETSA IKKHDPGASK SSVFERKISN VFTKATFGVN STFVLRGKRI 300
  301 LGDTNSIWAL SRDVHQGKVA KYSLISVNLN NGEVVYDEFE EPNLADEKLQ IRIKYLQPIE 360
  361 VLVNTDDLPL HVAKFFKDIS CPLIHKQEYD LEDHVVQAIK VMNEKIQLSP SLIRLVSKLY 420
  421 SHMVEYNNEQ VMLIPSIYSP FASKIHMLLD PNSLQSLDIF THDGGKGSLF WLLDHTRTSF 480
  481 GLRMLREWIL KPLVDVHQIE ERLDAIECIT SEINNSIFFE SLNQMLNHTP DLLRTLNRIM 540
  541 YGTTSRKEVY FYLKQITSFV DHFKMHQSYL SEHFKSSDGR IGKQSPLLFR LFSELNELLS 600
  601 TTQLPHFLTM INVSAVMEKN SDKQVMDFFN LNNYDCSEGI IKIQRESESV RSQLKEELAE 660
  661 IRKYLKRPYL NFRDEVDYLI EVKNSQIKDL PDDWIKVNNT KMVSRFTTPR TQKLTQKLEY 720
  721 YKDLLIRESE LQYKEFLNKI TAEYTELRKI TLNLAQYDCI LSLAATSCNV NYVRPTFVNG 780
  781 QQAIIAKNAR NPIIESLDVH YVPNDIMMSP ENGKINIITG PNMGGKSSYI RQVALLTIMA 840
  841 QIGSFVPAEE IRLSIFENVL TRIGAHDDII NGDSTFKVEM LDILHILKNC NKRSLLLLDE 900
  901 VGRGTGTHDG IAISYALIKY FSELSDCPLI LFTTHFPMLG EIKSPLIRNY HMDYVEEQKT 960
  961 GEDWMSVIFL YKLKKGLTYN SYGMNVAKLA RLDKDIINRA FSISEELRKE SINEDALKLF1020
 1021 SSLKRILKSD NITATDKLAK LLSLDIH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MSH2 MSH3
    View Details (MIPS) Mewes HW, et al. (2004) MSH2 MSH3 PMS1
    View Details Gavin AC, et al. (2002) CMR1 DNA2 HDA1 HDA2 HDA3 HSC82 KAP95 LCD1 MEC1 MGM101 MLH1 MPH1 MSH2 MSH3 MSH6 OLA1 PGK1 PMS1 PRO2 RAD16 RAD52 RFA1 RFA2 RFA3 RIM1 RNH1 RSC8 RVB2 SGS1 SHS1 TIF1, TIF2 TOP3 VAS1 VPS1 YHR122W
    View Details Ho Y, et al. (2002) BIO3 HTB1 MSH3
    View Details Qiu et al. (2008) MSH3 MSH6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..116] deduced N/A No confident structure predictions are available.
    2 View Details [117..281] PSI-BLAST 1510.457575 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    3 View Details [282..444] PSI-BLAST 1510.457575 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    4 View Details [445..467]
    [768..1047]    		 PSI-BLAST 1510.457575 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    5 View Details [468..632]
    [720..767]    		 PSI-BLAST 1510.457575 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    6 View Details [633..719] PSI-BLAST 1510.457575 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.39

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle