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Protein Overview: PMS1

General Information:
Name(s) found: PMS1 / YNL082W [SGD]
Description(s) found:
Found 23 descriptions.
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  • ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 873 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromosome [TASLink to PubMed article]
    Biological Process: meiotic mismatch repair [IMPLink to PubMed article]
    mismatch repair [TASLink to PubMed article]
    meiosis [TASLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]
    DNA binding [IDALink to PubMed article]
    ATP binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQIHQINDI DVHRITSGQV ITDLTTAVKE LVDNSIDANA NQIEIIFKDY GLESIECSDN  60
   61 GDGIDPSNYE FLALKHYTSK IAKFQDVAKV QTLGFRGEAL SSLCGIAKLS VITTTSPPKA 120
  121 DKLEYDMVGH ITSKTTTSRN KGTTVLVSQL FHNLPVRQKE FSKTFKRQFT KCLTVIQGYA 180
  181 IINAAIKFSV WNITPKGKKN LILSTMRNSS MRKNISSVFG AGGMRGLEEV DLVLDLNPFK 240
  241 NRMLGKYTDD PDFLDLDYKI RVKGYISQNS FGCGRNSKDR QFIYVNKRPV EYSTLLKCCN 300
  301 EVYKTFNNVQ FPAVFLNLEL PMSLIDVNVT PDKRVILLHN ERAVIDIFKT TLSDYYNRQE 360
  361 LALPKRMCSQ SEQQAQKRLK TEVFDDRSTT HESDNENYHT ARSESNQSNH AHFNSTTGVI 420
  421 DKSNGTELTS VMDGNYTNVT DVIGSECEVS VDSSVVLDEG NSSTPTKKLP SIKTDSQNLS 480
  481 DLNLNNFSNP EFQNITSPDK ARSLEKVVEE PVYFDIDGEK FQEKAVLSQA DGLVFVDNEC 540
  541 HEHTNDCCHQ ERRGSTDTEQ DDEADSIYAE IEPVEINVRT PLKNSRKSIS KDNYRSLSDG 600
  601 LTHRKFEDEI LEYNLSTKNF KEISKNGKQM SSIISKRKSE AQENIIKNKD ELEDFEQGEK 660
  661 YLTLTVSKND FKKMEVVGQF NLGFIIVTRK VDNKYDLFIV DQHASDEKYN FETLQAVTVF 720
  721 KSQKLIIPQP VELSVIDELV VLDNLPVFEK NGFKLKIDEE EEFGSRVKLL SLPTSKQTLF 780
  781 DLGDFNELIH LIKEDGGLRR DNIRCSKIRS MFAMRACRSS IMIGKPLNKK TMTRVVHNLS 840
  841 ELDKPWNCPH GRPTMRHLME LRDWSSFSKD YEI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MLH1 PMS1
    View Details (MIPS) Mewes HW, et al. (2004) MSH2 MSH3 PMS1
    View Details Krogan NJ, et al. (2006) NSA1 PMS1 RDR1
    View Details Gavin AC, et al. (2006) MLH1 PMS1
    View Details Gavin AC, et al. (2002) CMR1 DNA2 HDA1 HDA2 HDA3 HSC82 KAP95 LCD1 MEC1 MGM101 MLH1 MPH1 MSH2 MSH3 MSH6 OLA1 PGK1 PMS1 PRO2 RAD16 RAD52 RFA1 RFA2 RFA3 RIM1 RNH1 RSC8 RVB2 SGS1 SHS1 TIF1, TIF2 TOP3 VAS1 VPS1 YHR122W
    View Details Qiu et al. (2008) MSH2 PMS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PMS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..403] PSI-BLAST 68.39794 DNA mismatch repair protein PMS2
    2 View Details [404..590] MSA 4.434992 View MSA. No confident structure predictions are available.
    3 View Details [591..733] MSA 1.139986 View MSA. No confident structure predictions are available.
    4 View Details [734..826] deduced N/A No confident structure predictions are available.
    5 View Details [827..873] MSA 3.062993 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • mismatched DNA binding
    		•  8.69038541722775 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  7.03361327424191 bayes_pls_golite062009
    		• 6.04882684441736 bayes_pls_golite062009
  • guanine/thymine mispair binding
    		•  5.8954303695758 bayes_pls_golite062009
  • mismatch repair complex binding
    		•  5.63566878749852 bayes_pls_golite062009
  • single base insertion or deletion binding
    		•  5.36719395837475 bayes_pls_golite062009
  • dinucleotide insertion or deletion binding
    		•  4.91072939712457 bayes_pls_golite062009
  • loop DNA binding
    		•  4.26052361441101 bayes_pls_golite062009
  • DNA topoisomerase (ATP-hydrolyzing) activity
    		•  2.66323092512867 bayes_pls_golite062009
  • DNA topoisomerase activity
    		•  2.35776058207527 bayes_pls_golite062009
  • protein kinase activity
    		•  2.13536672517084 bayes_pls_golite062009
  • catalytic activity
    		•  2.10890475146569 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.77725015786603 bayes_pls_golite062009
  • kinase activity
    		•  1.68443268281997 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.64025200399404 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.37978051130887 bayes_pls_golite062009
  • DNA binding
    		•  1.31521246060081 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.22640171545155 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.22084067619837 bayes_pls_golite062009
  • transferase activity
    		•  1.09369139087478 bayes_pls_golite062009
  • exonuclease activity
    		•  1.02947145936572 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.996368427522977 bayes_pls_golite062009
  • signal transducer activity
    		•  0.996368427522977 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.91402301750067 bayes_pls_golite062009
  • binding
    		•  0.908938377164829 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.86218415868631 bayes_pls_golite062009
  • MutSalpha complex binding
    		•  0.8423412194292 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.839521076707668 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.75307991342421 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.71251019785001 bayes_pls_golite062009
  • nuclease activity
    		•  0.69721312877891 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.48105441429954 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.477960254167 bayes_pls_golite062009
  • structural molecule activity
    		•  0.41673693977319 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.36703663415044 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.350394896843651 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle