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Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA topoisomerase (ATP-hydrolyzing) activity
Acc: GO:0003918
Aspect: Molecular Function
Desc: Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
Synonyms:
  • DNA topoisomerase (ATP-hydrolysing)
  • topoisomerase II
  • DNA gyrase activity
  • DNA-gyrase activity
  • type II DNA topoisomerase activity
  • topoisomerase
  • deoxyribonucleic topoisomerase activity
  • deoxyribonucleate topoisomerase
  • DNA topoisomerase IV activity
  • DNA topoisomerase type II activity
  • DNA topoisomerase II
Proteins in PDR annotated with:
   This term: 71 [Search]
   Term or descendants: 71 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003918 - DNA topoisomerase (ATP-hydrolyzing) activity (interactive image map)
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