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Catalysis of the hydrolysis of any ester bond. Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates. Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. Catalysis of the site-specific cleavage of RNA by a catalytic RNA_mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA. Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules. Catalysis of the hydrolysis of ester linkages within nucleic acids. Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides. Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates. Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ribonuclease activity
Acc: GO:0004540
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
Proteins in PDR annotated with:
   This term: 206 [Search]
   Term or descendants: 724 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004540 - ribonuclease activity (interactive image map)
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