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Protein Overview: COQ6

General Information:
Name(s) found: COQ6 / YGR255C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 479 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: ubiquinone biosynthetic process [IMPLink to PubMed article]
    Molecular Function: ubiquinone biosynthetic process monooxygenase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFFSKVMLTR RILVRGLATA KSSAPKLTDV LIVGGGPAGL TLAASIKNSP QLKDLKTTLV  60
   61 DMVDLKDKLS DFYNSPPDYF TNRIVSVTPR SIHFLENNAG ATLMHDRIQS YDGLYVTDGC 120
  121 SKATLDLARD SMLCMIEIIN IQASLYNRIS QYDSKKDSID IIDNTKVVNI KHSDPNDPLS 180
  181 WPLVTLSNGE VYKTRLLVGA DGFNSPTRRF SQIPSRGWMY NAYGVVASMK LEYPPFKLRG 240
  241 WQRFLPTGPI AHLPMPENNA TLVWSSSERL SRLLLSLPPE SFTALINAAF VLEDADMNYY 300
  301 YRTLEDGSMD TDKLIEDIKF RTEEIYATLK DESDIDEIYP PRVVSIIDKT RARFPLKLTH 360
  361 ADRYCTDRVA LVGDAAHTTH PLAGQGLNMG QTDVHGLVYA LEKAMERGLD IGSSLSLEPF 420
  421 WAERYPSNNV LLGMADKLFK LYHTNFPPVV ALRTFGLNLT NKIGPVKNMI IDTLGGNEK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ASH1 COQ6 CTI6 DEP1 EAF3 GRX5 PHO23 RCO1 RPD3 RXT2 RXT3 SAP30 SAY1 SDS3 SIN3 UME1
    View Details Qiu et al. (2008) COQ6 GUT2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data COQ6 Huh WK, et al. (2003)
    View Data COQ6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110]
    [133..244]
    [356..426]
    [472..479]    		 PSI-BLAST 76.522879 p-Hydroxybenzoate hydroxylase, PHBH; p-Hydroxybenzoate hydroxylase (PHBH)
    2 View Details [111..132]
    [245..355]
    [427..471]    		 PSI-BLAST 76.522879 p-Hydroxybenzoate hydroxylase, PHBH; p-Hydroxybenzoate hydroxylase (PHBH)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.94752631746117 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.52511707514198 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.45104542724719 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.18990628739838 bayes_pls_golite062009
  • antioxidant activity
    		•  1.12347155061135 bayes_pls_golite062009
  • catalytic activity
    		•  1.03127962968326 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
    		•  0.876978863121464 bayes_pls_golite062009
  • binding
    		•  0.850689563354756 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  0.643810447309487 bayes_pls_golite062009
  • protein binding
    		•  0.370064403093958 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.23045510393832 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  0.130601418359425 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  0.0438965603843511 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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    Created and Maintained by: Michael Riffle