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Protein Overview: SPT7

General Information:
Name(s) found: SPT7 / YBR081C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1332 amino acids

    Gene Ontology:
    Cellular Component: SLIK (SAGA-like) complex [IPILink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    SAGA complex [IDALink to PubMed article]
    Biological Process: chromatin modification [TASLink to PubMed article]
    protein complex assembly [IMPLink to PubMed articleLink to PubMed article]
    conjugation with cellular fusion [IMPLink to PubMed article]
    histone acetylation [TASLink to PubMed article]
    Molecular Function: structural molecule activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTERIPIKNY QRTNAKALLK LTEKLFNKNF FDLYLTSQQL VVLEYLLSIS SEEDKLKAWD  60
   61 YFLKGNIALN VEKSFPLTQE EEHHGAVSPA VDTRSDDVSS QTIKDNNNTN TNTSISNENH 120
  121 VENEIEDKGD NAIANEDNFV NNDESDNVEE DLFKLDLEDL KQQISGTRFI GNLSLKIRYV 180
  181 LWQCAIDYIY CDRNEFGDEN DTEYTLLDVE EKEEEEIGKN EKPQNKEGIS KFAEDEDYDD 240
  241 EDENYDEDST DVKNVDDPPK NLDSISSSNI EIDDERRLVL NISISKETLS KLKTNNVEEI 300
  301 MGNWNKIYHS FEYDKETMIK RLKLEESDKM IEKGKKKRSR SDLEAATDEQ DRENTNDEPD 360
  361 TNQKLPTPEG STFSDTGNKR PKQSNLDLTV NLGIENLSLK HLLSSIQQKK SQLGISDYEL 420
  421 KHLIMDVRKN RSKWTSDERI GQEELYEACE KVVLELRNYT EHSTPFLNKV SKREAPNYHQ 480
  481 IIKKSMDLNT VLKKLKSFQY DSKQEFVDDI MLIWKNCLTY NSDPSHFLRG HAIAMQKKSL 540
  541 QLIRMIPNIT IRNRADLEKE IEDMEKDKDY ELDEEEEVAG SGRKGLNMGA HMLAKENGKV 600
  601 SEKDSSKTVK DEAPTNDDKL TSVIPEGEKE KDKTASSTVT VHENVNKNEI KENGKNEEQD 660
  661 MVEESSKTED SSKDADAAKK DTEDGLQDKT AENKEAGENN EEEEDDDDED EDEDMVDSQS 720
  721 YLLEKDDDRD DLEISVWKTV TAKVRAEICL KRTEYFKNGK LNSDSEAFLK NPQRMKRFDQ 780
  781 LFLEYKEQKA LESYRQKIEQ NSIMKNGFGT VLKQEDDDQL QFHNDHSLNG NEAFEKQPND 840
  841 IELDDTRFLQ EYDISNAIPD IVYEGVNTKT LDKMEDASVD RMLQNGINKQ SRFLANKDLG 900
  901 LTPKMNQNIT LIQQIRHICH KISLIRMLQS PLSAQNSRSN PNAFLNNHIY NYTIIDDSLD 960
  961 IDPVSQLPTH DYKNNRELIW KFMHKNISKV AMANGFETAH PSAINMLTEI AGDYLSNLIK1020
 1021 TLKLHHETNS LNRGTNVEML QTTLLENGIN RPDDLFSYVE SEFGKKTKKL QDIKQKLESF1080
 1081 LRALLRPTLQ ELSERNFEDE SQSFFTGDFA SELTGEDFFG FRELGLEKEF GVLSSSVPLQ1140
 1141 LLTTQFQTVD GETKVQAKKI QPEESDSIVY KKITKGMLDA GSFWNTLLPL LQKDYERSKA1200
 1201 YIAKQSKSSA NDKTSMTSTE DNSFALLEED QFVSKKTATK ARLPPTGKIS TTYKKKPIAS1260
 1261 AFILPEEDLE NDVKADPTTT VNAKVGAEND GDSSLFLRTP QPLDPLDMDD AFDDTNMGSN1320
 1321 SSFSLSLPRL NQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADA2 GCN5 HFI1 NGG1 SGF11 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 TRA1 UBP8
    View Details (MIPS) Mewes HW, et al. (2004) ADA2 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF10 TAF12 TAF5 TAF6 TAF9 TRA1
    View Details Krogan NJ, et al. (2006) ADA2 AHC1 AHC2 FMP40 GCN5 HFI1 MSS4 NGG1 PDR15 RAD59 REV3 SGF11 SGF29 SGF73 SNL1 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 UBP8 YMR007W
    View Details Gavin AC, et al. (2006) ADA2 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8
    View Details Gavin AC, et al. (2002) ADA2 ADH1 CCL1 CLU1 COG3 CSE2 DCS2 ENO2 FAB1 FAP1 FBA1 FPR1 FUN19 GAL11 GCN5 HEM13 HFI1 KAP114 KAP123 KAP95 KIN28 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MES1 MLP1 MNN4 MOT1 MRPL6 MRPS28 MYO1 MYO4 NGG1 NOP1 NUT1 NUT2 PFK2 PGD1 PGK1 PSK1 PTC1 PUF6 RGR1 ROX3 RPB2 RPG1 RPN9 RPO21 RPT5 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SSE2 SSL1 SSN2 SSN3 SSN8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 TFA1 TFB1 TFB3 TFB4 TIF1, TIF2 TIF6 UBP8 VAS1 VPS1 YIL077C
    View Details Ho Y, et al. (2002) ADA2 ARP4 FAA2 FET4 GCN5 HFI1 RPO31 RTF1 SGF29 SPT7 STB4 SWC4 SWI5 TAF6 TDA3 TRA1 UBP8
    View Details Qiu et al. (2008) ADA2 ARP4 EPL1 GAL11 GCN5 HFI1 MED1 NGG1 SGF29 SGF73 SIN4 SPT20 SPT3 SPT7 SPT8 SUS1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF5 TAF6 TAF9 TRA1 UBP8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SPT7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..329] PSI-BLAST 10.69897 Heavy meromyosin subfragment
    2 View Details [330..389] deduced N/A No confident structure predictions are available.
    3 View Details [390..558] PSI-BLAST 101.69897 GCN5
    4 View Details [559..632] ORFEUS 14.09 No description for 1l8mA was found.
    5 View Details [633..711] ORFEUS 14.09 No description for 1l8mA was found.
    6 View Details [712..781] ORFEUS 14.09 No description for 1l8mA was found.
    7 View Details [782..901] ORFEUS 14.09 No description for 1l8mA was found.
    8 View Details [902..1332] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle