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Protein Overview: SRB8

General Information:
Name(s) found: SRB8 / YCR081W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1427 amino acids

    Gene Ontology:
    Cellular Component: transcription factor complex [TASLink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [TASLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: RNA polymerase II transcription mediator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNGSGRYLL TPPDDLHPYV PSSKPQEQVY PDFKPWEHTA AEDQILANFV AKGFYHTPMV  60
   61 NFESISARSS VHESLVTQSN ILSQQFDKII KIREDHINKI PSNSTTTLHG PGFQLPNRIT 120
  121 LTDHRKETWL HELSSSHTSL VKIGKFIPHG LKRRQVIEQC YLKFIPLKRA IWLIKCCYFI 180
  181 EWKSNHKKKR SNAAGADDAI SMHLLKDWTD TFVYILEKLI FDMTNHYNDS QQLRTWKRQI 240
  241 SYFLKLLGNC YSLRLINKEI FHHWLVEFIN KMENFEFLPL SLHILMIFWN DICQIDTNAP 300
  301 VAATITSSQK EPFFLVTKIT DMLLHKYYIV SSSKSMINDE NYIINDIKKN NKIKLNILKI 360
  361 LSSLILKIFQ EQSLEVFIFP TSNWEIYKPL LFEIVSNADT NQNSDMKKKL ELISYRNESL 420
  421 KNNSSIRNVI MSASNANDFQ LTIVTCKQFP KLSCIQLNCI DTQFTKLLDD NPTEFDWPTY 480
  481 VDQNPLTMHK IIQLILWSIH PSRQFDHYES NQLVAKLLLL RINSTDEDLH EFQIEDAIWS 540
  541 LVFQLAKNFS AQKRVVSYMM PSLYRLLNIL ITYGIIKVPT YIRKLISSGL LYLQDSNDKF 600
  601 VHVQLLINLK ISPLMKSQYN MVLRNVMEYD VKFYEIFNFD QLVEITEQIK MRILSNDITN 660
  661 LQLSKTPLSI KIMVAEWYLS HLCSGILSSV NRTVLLKIFK IFCIDLEVFH HFFKWIEFIV 720
  721 YHQLLSDIES LEALMDILLC YQKLFSQFIN DHILFTKTFI FIYKKVLKEK DVPAYNVTSF 780
  781 MPFWKFFMKN FPFVLKVDND LRIELQSVYN DEKLKTEKLK NDKSEVLKVY SMINNSNQAV 840
  841 GQTWNFPEVF QVNIRFLLHN SEIIDTNTSK QFQKARNNVM LLIATNLKEY NKFMSIFLKR 900
  901 KDFTNKNLIQ LISLKLLTFE VTQNVLGLEY IIRLLPINLE NNDGSYGLFL KYHKEQFIKS 960
  961 NFEKILLTCY ELEKKYHGNE CEINYYEILL KILITYGSSP KLLATSTKII MLLLNDSVEN1020
 1021 SSNILEDILY YSTCPSETDL NDIPLGSGQP DNDTVVTNDD KSDDDDHTVD EIDHVEYYVM1080
 1081 MDFANLWVFQ AFTCFCIKKI MENNEPAMAM EDLKNFIFQI IEITNSNDLC SQIFDQLKDM1140
 1141 QTIEMITQIV EKDFCTSCLQ NNNQKIDDNY IVVVIEIITS LSMRFQRETS GMIVISMENY1200
 1201 HLLIKIIRQL SELNEGNLSK REIQIDAVLK IFSFHQDSIF QRIIADLSAD KPTSPFIDSI1260
 1261 CKLFDKISFN LRLKLFLYEI LSSLKSFAIY SSTIDAPAFH TSGKVELPKK LLNLPPFQVS1320
 1321 SFVKETKLHS GDYGEEEDAD QEESFSLNLG IGIVEIAHEN EQKWLIYDKK DHKYVCTFSM1380
 1381 EPYHFISNYN TKYTDDMATG SNDTTAFNDS CVNLSLFDAR FERKNPH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADA2 CSE2 GAL11 MED1 MED11 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SSN2 SSN3 YAP1
    View Details (MIPS) Mewes HW, et al. (2004) SRB8 SSN2 SSN3 SSN8
    View Details Krogan NJ, et al. (2006) HTD2 SRB8 SSN2
    View Details Gavin AC, et al. (2006) CSE2 GAL11 MED1 MED11 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SSN2
    View Details Gavin AC, et al. (2002) ADA2 ADH1 COG3 CSE2 ENO2 FAB1 FBA1 GAL11 GCN5 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MLP1 MRPL6 NUT1 NUT2 PGD1 PGK1 RGR1 ROX3 RPG1 RPO21 SIN4 SPT7 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SSE2 SSN2 SSN3 SSN8 TAF6 TIF1, TIF2 YIL077C
    View Details Qiu et al. (2008) SRB4 SRB8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SRB8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..340] MSA 4.012926 View MSA. No confident structure predictions are available.
    2 View Details [341..665] deduced N/A No confident structure predictions are available.
    3 View Details [666..1059] MSA 1.003 View MSA. No confident structure predictions are available.
    4 View Details [1060..1427] deduced N/A No confident structure predictions are available.
    5 View Details [548..637] deduced N/A No confident structure predictions are available.
    6 View Details [638..845] deduced N/A No confident structure predictions are available.
    7 View Details [846..1058] deduced N/A No confident structure predictions are available.
    8 View Details [1059..1251] deduced N/A No confident structure predictions are available.
    9 View Details [1252..1427] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle