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Protein Overview: YBR090C-A, NHP6B

General Information:
Name(s) found: YBR090C-A [SGD]
NHP6B / YBR089C-A [SGD]
Description(s) found:
Found 21 descriptions.
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  • Chromosome II from 426443 to 426144 [SGD]
  • High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 99 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromatin [ISSLink to PubMed article]
    Biological Process: chromatin remodeling [IMPLink to PubMed article]
    chromatin organization [ISSLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article][IPILink to PubMed article]
    regulation of transcription from RNA polymerase III promoter [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [ISSLink to PubMed article]
    Molecular Function: chromatin binding [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAATKEAKQP KEPKKRTTRR KKDPNAPKRR LSAYMFFANE NRDIVRSENP DVTFGQVGRI  60
   61 LGERWKALTA EEKQPYESKA QADKKRYESE KELYNATRA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) ADE5,7 HHF1, HHF2 IOC3 ISW1 ISW2 ITC1 MOT1 NPL6 REB1 RFA1 RFX1 RNR2 RPC34 RPC40 RPO31 RSC2 RSC3 RSC58 RSC8 RVB2 SFH1 STH1 STO1 TAF1 TFC7 TOP1 VPS1 YBR090C-A, NHP6B
    View Details Qiu et al. (2008) NHP6A PCC1 YBR090C-A, NHP6B

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YBR090C-A, NHP6B Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..99] PSI-BLAST 284.0103 NHP6a

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  5.15324651287773 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.01228762819617 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.9607192917135 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.06355503548774 bayes_pls_golite062009
  • transcription factor activity
    		•  3.82658263870186 bayes_pls_golite062009
  • binding
    		•  3.6211482127468 bayes_pls_golite062009
  • transcription activator activity
    		•  2.95665802871704 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.75319687398598 bayes_pls_golite062009
  • protein binding
    		•  2.18211240370246 bayes_pls_golite062009
  • chromatin binding
    		•  1.64428658020027 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.53825678633232 bayes_pls_golite062009
  • transcription factor binding
    		•  1.10315330167937 bayes_pls_golite062009
  • DNA bending activity
    		•  0.87985209274756 bayes_pls_golite062009
  • crossed form four-way junction DNA binding
    		•  0.293183929205961 bayes_pls_golite062009
  • bent DNA binding
    		•  0.293183929205961 bayes_pls_golite062009
  • open form four-way junction DNA binding
    		•  0.293183929205961 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.261169200304829 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle