YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: SNF2

General Information:
Name(s) found: SNF2 / YOR290C [SGD]
Description(s) found:
Found 33 descriptions.
SHOW ALL
  • Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1703 amino acids

    Gene Ontology:
    Cellular Component: SWI/SNF complex [TASLink to PubMed article]
    chromatin remodeling complex [TASLink to PubMed article]
    Biological Process: chromatin remodeling [TASLink to PubMed article]
    double-strand break repair [IMPLink to PubMed article]
    Molecular Function: DNA-dependent ATPase activity [IDALink to PubMed article][IMPLink to PubMed article]
    general RNA polymerase II transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIPQRQFSN EEVNRCYLRW QHLRNEHGMN APSVPEFIYL TKVLQFAAKQ RQELQMQRQQ  60
   61 QGISGSQQNI VPNSSDQAEL PNNASSHISA SASPHLAPNM QLNGNETFST SAHQSPIMQT 120
  121 QMPLNSNGGN NMLPQRQSSV GSLNATNFSP TPANNGENAA EKPDNSNHNN LNLNNSELQP 180
  181 QNRSLQEHNI QDSNVMPGSQ INSPMPQQAQ MQQAQFQAQQ AQQAQQAQQA QQAQARLQQG 240
  241 RRLPMTMFTA EQSELLKAQI TSLKCLVNRK PIPFEFQAVI QKSINHPPDF KRMLLSLSEF 300
  301 ARRRQPTDQN NQSNLNGGNN TQQPGTNSHY NNTNTDNVSG LTRNAPLDSK DENFASVSPA 360
  361 GPSSVHNAKN GTLDKNSQTV SGTPITQTES KKEENETISN VAKTAPNSNK THTEQNNPPK 420
  421 PQKPVPLNVL QDQYKEGIKV VDIDDPDMMV DSFTMPNISH SNIDYQTLLA NSDHAKFTIE 480
  481 PGVLPVGIDT HTATDIYQTL IALNLDTTVN DCLDKLLNDE CTESTRENAL YDYYALQLLP 540
  541 LQKAVRGHVL QFEWHQNSLL TNTHPNFLSK IRNINVQDAL LTNQLYKNHE LLKLERKKTE 600
  601 AVARLKSMNK SAINQYNRRQ DKKNKRLKFG HRLIATHTNL ERDEQKRAEK KAKERLQALK 660
  661 ANDEEAYIKL LDQTKDTRIT HLLRQTNAFL DSLTRAVKDQ QKYTKEMIDS HIKEASEEVD 720
  721 DLSMVPKMKD EEYDDDDDNS NVDYYNVAHR IKEDIKKQPS ILVGGTLKDY QIKGLQWMVS 780
  781 LFNNHLNGIL ADEMGLGKTI QTISLLTYLY EMKNIRGPYL VIVPLSTLSN WSSEFAKWAP 840
  841 TLRTISFKGS PNERKAKQAK IRAGEFDVVL TTFEYIIKER ALLSKVKWVH MIIDEGHRMK 900
  901 NAQSKLSLTL NTHYHADYRL ILTGTPLQNN LPELWALLNF VLPKIFNSVK SFDEWFNTPF 960
  961 ANTGGQDKIE LSEEETLLVI RRLHKVLRPF LLRRLKKDVE KELPDKVEKV VKCKMSALQQ1020
 1021 IMYQQMLKYR RLFIGDQNNK KMVGLRGFNN QIMQLKKICN HPFVFEEVED QINPTRETND1080
 1081 DIWRVAGKFE LLDRILPKLK ATGHRVLIFF QMTQIMDIME DFLRYINIKY LRLDGHTKSD1140
 1141 ERSELLRLFN APDSEYLCFI LSTRAGGLGL NLQTADTVII FDTDWNPHQD LQAQDRAHRI1200
 1201 GQKNEVRILR LITTNSVEEV ILERAYKKLD IDGKVIQAGK FDNKSTSEEQ EALLRSLLDA1260
 1261 EEERRKKRES GVEEEEELKD SEINEILARN DEEMAVLTRM DEDRSKKEEE LGVKSRLLEK1320
 1321 SELPDIYSRD IGAELKREES ESAAVYNGRG ARERKTATYN DNMSEEQWLR QFEVSDDEKN1380
 1381 DKQARKQRTK KEDKSEAIDG NGEIKGENID ADNDGPRINN ISAEDRADTD LAMNDDDFLS1440
 1441 KKRKAGRPRG RPKKVKLEGS ENSEPPALES SPVTGDNSPS EDFMDIPKPR TAGKTSVKSA1500
 1501 RTSTRGRGRG RGRGRGRGRG RGRPPKARNG LDYVRTPAAA TSPIDIREKV AKQALDLYHF1560
 1561 ALNYENEAGR KLSDIFLSKP SKALYPDYYM IIKYPVAFDN INTHIETLAY NSLKETLQDF1620
 1621 HLIFSNARIY NTEGSVVYED SLELEKVVTK KYCEIMGDNS QLDFTEFDEQ YGTRPLVLPP1680
 1681 VVTSSVAESF TDEADSSMTE ASV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARP7 ARP9 SNF12 SNF2 SNF5 SNF6 SWI1 SWI3 SWP82
    View Details (MIPS) Mewes HW, et al. (2004) ARP7 ARP9 SNF11 SNF12 SNF2 SNF5 SNF6 SWI1 SWI3 TAF14
    View Details Krogan NJ, et al. (2006) SNF12 SNF2 SNF5 SNF6 SWI1 SWI3 SWP82
    View Details Gavin AC, et al. (2002) ADH1 ARP9 ATG26 BEM2 BUD3 CBF5 COP1 CPR1 CYR1 DIM1 ECM16 EMG1 ENP1 HCA4 HHF1, HHF2 HOS2 HOS4 HRR25 IMG1 IMG2 IML1 IMP3 IMP4 KAP95 KRE33 KRR1 LHP1 LTV1 MHR1 MPP10 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 NAB3 NAB6 NAM7 NOB1 NOC4 NOP1 NOP14 NPL3 NRD1 NRP1 NUG1 PNO1 POL2 PRP43 PUB1 RCL1 RET2 RIO2 ROM2 RRP12 RTC6 RVB2 SAM1 SEC1 SEC26 SEC27 SET3 SGN1 SIF2 SIN4 SLX9 SMD3 SNF12 SNF2 SNF5 SNF6 SNT1 SOF1 STO1 SWI1 SWI3 SWP82 SYP1 TAF5 TIF4631 TIF4632 TSR1 UTP15 UTP20 UTP22 UTP6 UTP7 VPS1 YDR115W YGR054W YML6
    View Details Qiu et al. (2008) ARP7 ARP9 SNF11 SNF12 SNF2 SNF5 SNF6 SWI1 SWI3 TAF14 TAF5 TFB5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB3 No Comments Hazbun TR, et al. (2003)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SNF2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..404] MSA 28.176997 View MSA. No confident structure predictions are available.
    2 View Details [405..708] deduced N/A No confident structure predictions are available.
    3 View Details [709..962] PSI-BLAST 7.221849 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    4 View Details [963..1014] deduced N/A No confident structure predictions are available.
    5 View Details [1015..1086] PSI-BLAST 7.39794 Putative DEAD box RNA helicase
    6 View Details [1087..1347] PSI-BLAST 5.39794 Nucleotide excision repair enzyme UvrB
    7 View Details [1348..1510] deduced N/A No confident structure predictions are available.
    8 View Details [1511..1703] PSI-BLAST 87.10721 GCN5

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  2.4348680404207 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.07968294254548 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription activator activity
    		•  0.889929694023098 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • motor activity
    		•  0.677658554107 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.543891899378373 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.31144582840038 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.243902356228423 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.18426050934025 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.14606996093053 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.13050483816765 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.11674780318211 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle