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Protein Overview: NAM7

General Information:
Name(s) found: NAM7 / YMR080C [SGD]
Description(s) found:
Found 31 descriptions.
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  • ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 971 amino acids

    Gene Ontology:
    Cellular Component: polysome [TASLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    [NOT]mitochondrion [IDALink to PubMed article]
    Biological Process: regulation of translational termination [TASLink to PubMed article]
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TASLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    [NOT]translational frameshifting [IMPLink to PubMed article]
    mRNA catabolic process [TASLink to PubMed article]
    chromatin silencing at silent mating-type cassette [IGILink to PubMed article]
    Molecular Function: nucleic acid binding [TASLink to PubMed article]
    RNA-dependent ATPase activity [TASLink to PubMed article]
    ATP-dependent RNA helicase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVGSGSHTPY DISNSPSDVN VQPATQLNST LVEDDDVDNQ LFEEAQVTET GFRSPSASDN  60
   61 SCAYCGIDSA KCVIKCNSCK KWFCNTKNGT SSSHIVNHLV LSHHNVVSLH PDSDLGDTVL 120
  121 ECYNCGRKNV FLLGFVSAKS EAVVVLLCRI PCAQTKNANW DTDQWQPLIE DRQLLSWVAE 180
  181 QPTEEEKLKA RLITPSQISK LEAKWRSNKD ATINDIDAPE EQEAIPPLLL RYQDAYEYQR 240
  241 SYGPLIKLEA DYDKQLKESQ ALEHISVSWS LALNNRHLAS FTLSTFESNE LKVAIGDEMI 300
  301 LWYSGMQHPD WEGRGYIVRL PNSFQDTFTL ELKPSKTPPP THLTTGFTAE FIWKGTSYDR 360
  361 MQDALKKFAI DKKSISGYLY YKILGHQVVD ISFDVPLPKE FSIPNFAQLN SSQSNAVSHV 420
  421 LQRPLSLIQG PPGTGKTVTS ATIVYHLSKI HKDRILVCAP SNVAVDHLAA KLRDLGLKVV 480
  481 RLTAKSREDV ESSVSNLALH NLVGRGAKGE LKNLLKLKDE VGELSASDTK RFVKLVRKTE 540
  541 AEILNKADVV CCTCVGAGDK RLDTKFRTVL IDESTQASEP ECLIPIVKGA KQVILVGDHQ 600
  601 QLGPVILERK AADAGLKQSL FERLISLGHV PIRLEVQYRM NPYLSEFPSN MFYEGSLQNG 660
  661 VTIEQRTVPN SKFPWPIRGI PMMFWANYGR EEISANGTSF LNRIEAMNCE RIITKLFRDG 720
  721 VKPEQIGVIT PYEGQRAYIL QYMQMNGSLD KDLYIKVEVA SVDAFQGREK DYIILSCVRA 780
  781 NEQQAIGFLR DPRRLNVGLT RAKYGLVILG NPRSLARNTL WNHLLIHFRE KGCLVEGTLD 840
  841 NLQLCTVQLV RPQPRKTERP MNAQFNVESE MGDFPKFQDF DAQSMVSFSG QIGDFGNAFV 900
  901 DNTELSSYIN NEYWNFENFK SAFSQKQNRN EIDDRNLYQE EASHLNSNFA RELQREEQKH 960
  961 ELSKDFSNLG I

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NAM7 SGN1
    View Details (MIPS) Mewes HW, et al. (2004) NAM7 NMD2 UPF3
    View Details Gavin AC, et al. (2006) ADH3 NAM7
    View Details Gavin AC, et al. (2002) ASC1 CDC33 CLF1 CWC23 DCP2 DHH1 DIB1 ERB1 HCA4 IML1 KRS1 LHP1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 NAB3 NAB6 NAM7 NOG2 NOP1 NPL3 NRD1 NRP1 NUG1 PAT1 POL2 PRP24 PRP31 PRP38 PRP4 PRP43 PRP46 PRP6 PUB1 SGN1 SMB1 SMD2 SMD3 SNF2 SNU114 SNU23 SNU66 SPP382 SQS1 SRO9 STO1 SWI1 TIF4631 TIF4632
    View Details Qiu et al. (2008) ECM32 MKT1 NAM7 NMD2 SSB1 UPF3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NAM7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..224] deduced N/A No confident structure predictions are available.
    2 View Details [225..389] MSA 1.198991 View MSA. No confident structure predictions are available.
    3 View Details [390..638] PSI-BLAST 89.0 DEXX box DNA helicase
    4 View Details [639..971] PSI-BLAST 89.0 DEXX box DNA helicase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle