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Protein Overview: DCP2

General Information:
Name(s) found: DCP2 / YNL118C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 970 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytoplasmic mRNA processing body [IDALink to PubMed article]
    Biological Process: deadenylation-independent decapping of nuclear-transcribed mRNA [IMPLink to PubMed article]
    deadenylation-dependent decapping of nuclear-transcribed mRNA [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    mRNA catabolic process [TASLink to PubMed article]
    Molecular Function: mRNA binding [IPILink to PubMed article]
    m7G(5')pppN diphosphatase activity [IDALink to PubMed article]
    hydrolase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPLRHALE NVTSVDRILE DLLVRFIINC PNEDLSSVER ELFHFEEASW FYTDFIKLMN  60
   61 PTLPSLKIKS FAQLIIKLCP LVWKWDIRVD EALQQFSKYK KSIPVRGAAI FNENLSKILL 120
  121 VQGTESDSWS FPRGKISKDE NDIDCCIREV KEEIGFDLTD YIDDNQFIER NIQGKNYKIF 180
  181 LISGVSEVFN FKPQVRNEID KIEWFDFKKI SKTMYKSNIK YYLINSMMRP LSMWLRHQRQ 240
  241 IKNEDQLKSY AEEQLKLLLG ITKEEQIDPG RELLNMLHTA VQANSNNNAV SNGQVPSSQE 300
  301 LQHLKEQSGE HNQQKDQQSS FSSQQQPSIF PSLSEPFANN KNVIPPTMPM ANVFMSNPQL 360
  361 FATMNGQPFA PFPFMLPLTN NSNSANPIPT PVPPNFNAPP NPMAFGVPNM HNLSGPAVSQ 420
  421 PFSLPPAPLP RDSGYSSSSP GQLLDILNSK KPDSNVQSSK KPKLKILQRG TDLNSIKQNN 480
  481 NDETAHSNSQ ALLDLLKKPT SSQKIHASKP DTSFLPNDSV SGIQDAEYED FESSSDEEVE 540
  541 TARDERNSLN VDIGVNVMPS EKDSRRSQKE KPRNDASKTN LNASAESNSV EWGPGKSSPS 600
  601 TQSKQNSSVG MQNKYRQEIH IGDSDAYEVF ESSSDEEDGK KLEELEQTQD NSKLISQDIL 660
  661 KENNFQDGEV PHRDMPTESN KSINETVGLS STTNTVKKVP KVKILKRGET FASLANDKKA 720
  721 FDSSSNVSSS KDLLQMLRNP ISSTVSSNQQ SPKSQHLSGD EEIMMMLKRN SVSKPQNSEE 780
  781 NASTSSINDA NASELLGMLK QKEKDITAPK QPYNVDSYSQ KNSAKGLLNI LKKNDSTGYP 840
  841 RTEGGPSSEM STSMKRNDAT NNQELDKNST ELLNYLKPKP LNDGYENISN KDSSHELLNI 900
  901 LHGNKNSSAF NNNVYATDGY SLASDNNENS SNKLLNMLQN RSSAINEPNF DVRSNGTSGS 960
  961 NELLSILHRK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DCP1 DCP2 DHH1 EDC3 LSM4
    View Details Krogan NJ, et al. (2006) DCP1 DCP2 EDC2 EDC3 PBY1
    View Details Gavin AC, et al. (2006) DCP1 DCP2 EDC3
    View Details Gavin AC, et al. (2002) ARX1 ASC1 BEM2 BMS1 BRX1 BUD20 CDC33 CIC1 CLF1 CLU1 CWC23 CYR1 CYS4 DBP10 DBP9 DCP1 DCP2 DHH1 DIB1 DRS1 EBP2 EDC3 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 KRS1 LHP1 LOC1 LSG1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAK21 MAK5 MDN1 MIS1 MRT4 NAM7 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PAT1 PRP24 PRP31 PRP38 PRP4 PRP43 PRP46 PRP6 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPM2 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SMB1 SMD2 SNU114 SNU13 SNU23 SNU66 SPB1 SPB4 SPP382 SQS1 SRO9 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) ABP1 ACO1 AIM41 ATP4 BUD14 CAR2 CDC25 CKA2 COR1 CRZ1 CYS4 DCP1 DCP2 DHH1 DNM1 EDC3 EDE1 EGD2 ENP1 FPR3 GAS1 GCN3 GLC7 GPG1 GPH1 HHF1, HHF2 HRR25 HSP104 HXT7 HYP2 IPP1 LOC1 LSM1 LSM4 LSM7 LSP1 LTV1 MDH1 MDS3 MGE1 NSA1 NUG1 OYE2 PAT1 PEX19 PIL1 PIN4 PTC4 PUF3 RIO2 RPC19 RPM2 SAP185 SAP190 SAS10 SEC2 SEC23 SES1 SFB3 SGM1 SIT4 TGL1 TMA19 TSR1 VMA4 YBR225W YER138C
    View Details Qiu et al. (2008) DCP1 DCP2 DCS1 DCS2 DHH1 EDC3 KEM1 LSM1 PAT1 RPB4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DCP2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..64] deduced N/A No confident structure predictions are available.
    2 View Details [65..267] PSI-BLAST 19.0 Nucleoside triphosphate pyrophosphorylase (MutT)
    3 View Details [268..508] ORFEUS 11.75 Fibrinogen
    4 View Details [509..587] deduced N/A No confident structure predictions are available.
    5 View Details [588..594]
    [821..903]    		 ORFEUS 8.74 No description for 1l8mA was found.
    6 View Details [595..667] ORFEUS 8.74 No description for 1l8mA was found.
    7 View Details [668..750] ORFEUS 8.74 No description for 1l8mA was found.
    8 View Details [751..820] ORFEUS 8.74 No description for 1l8mA was found.
    9 View Details [904..970] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle