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Protein Overview: TGL1

General Information:
Name(s) found: TGL1 / YKL140W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 548 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDALink to PubMed articleLink to PubMed article]
    integral to membrane [IDALink to PubMed article]
    Biological Process: lipid metabolic process [IMPLink to PubMed article]
    sterol metabolic process [IMPLink to PubMed article]
    Molecular Function: sterol esterase activity [IDALink to PubMed article]
    lipase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYFPFLGRLS ITDYIIVVLV YIESIISSVL KLIPQPMINL FEWLINFSTS SDDNTIEEKL  60
   61 RSAPTIHEMC AIFDISVEDH LVRTEDNYIL TLHRIPPISK NRFNNKVVYL HHGLLMCSDV 120
  121 WCCNIERHKN LPFVLHDLGY DVWMGNNRGN KYSTAHLNKP PKSNKFWDFS IDEFAFFDIP 180
  181 NSIEFILDIT KVDKVICIGF SQGSAQMFAA FSLSEKLNRK VSHFIAIAPA MTPKGLHNRI 240
  241 VDTLAKSSPG FMYLFFGRKI VLPSAVIWQR TLHPTLFNLC IDIANKILFN WKSFNILPRQ 300
  301 KIASYAKLYS TTSVKSIVHW FQILRSQKFQ MFEESDNMLN SLTRPYQIAN FPTRTNIKIP 360
  361 ILLIYGGIDS LVDIDVMKKN LPFNSVFDVK VDNYEHLDLI WGKDADTLVI AKVLRFIEFF 420
  421 NPGNVSVKTN QLLPSASLVE ELPSTTWKTT HPTHGLSYRT HSADRSPLSV QADEADEVHN 480
  481 ADNSRFLRRV FSTSAIDEDN ENEHQDDTED QIHKEQQRRL SAYLESSKDL RQLDANSSTT 540
  541 ALDALNKE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CDC25 CKA2 DCP2 EDC3 EDE1 ENP1 FPR3 GLC7 HRR25 MDS3 RPM2 SEC23 SFB3 SGM1 SIT4 TGL1 TSR1
    View Details Qiu et al. (2008) TGL1 TGL3 TGL4 TGL5 YEH1 YEH2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TGL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..463] PSI-BLAST 526.554485 Gastric lipase
    2 View Details [464..548] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  3.20549979663539 bayes_pls_golite062009
  • malate dehydrogenase activity
    		•  2.28093794718528 bayes_pls_golite062009
  • palmitoyl-(protein) hydrolase activity
    		•  2.14423515928317 bayes_pls_golite062009
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • triglyceride lipase activity
    		•  1.2959733599348 bayes_pls_golite062009
  • sterol esterase activity
    		•  1.21262745914703 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  1.18565704009692 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.985235528680562 bayes_pls_golite062009
  • palmitoyl-CoA hydrolase activity
    		•  0.92549140936125 bayes_pls_golite062009
  • peptidase activity
    		•  0.858311047004898 bayes_pls_golite062009
  • lipase activity
    		•  0.849473630399459 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.590445773074315 bayes_pls_golite062009
  • carboxylesterase activity
    		•  0.424330502936163 bayes_pls_golite062009
  • binding
    		•  0.351031277062254 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle