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Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: (S)-malate + acceptor = oxaloacetate + reduced acceptor. Catalysis of the reaction: (R)-malate + NAD+ = pyruvate + CO2 + NADH + H+.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: malate dehydrogenase activity
Acc: GO:0016615
Aspect: Molecular Function
Desc: Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
Proteins in PDR annotated with:
   This term: 43 [Search]
   Term or descendants: 115 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016615 - malate dehydrogenase activity (interactive image map)

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