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Protein Overview: TGL4

General Information:
Name(s) found: TGL4 / YKR089C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 910 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: triglyceride catabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    triglyceride mobilization [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: triglyceride lipase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKISDLTS TQNKPLLVTQ QLIEKYYEQI LGTSQNIIPI LNPKNKFIRP SKDNSDVERV  60
   61 EEDAGKRLQT GKNKTTNKVN FNLDTGNEDK LDDDQETVTE NENNDIEMVE TDEGEDERQG 120
  121 SSLASKCKSF LYNVFVGNYE RDILIDKVCS QKQHAMSFEE WCSAGARLDD LTGKTEWKQK 180
  181 LESPLYDYKL IKDLTSRMRE ERLNRNYAQL LYIIRTNWVR NLGNMGNVNL YRHSHVGTKY 240
  241 LIDEYMMESR LALESLMESD LDDSYLLGIL QQTRRNIGRT ALVLSGGGTF GLFHIGVLGT 300
  301 LFELDLLPRV ISGSSAGAIV ASILSVHHKE EIPVLLNHIL DKEFNIFKDD KQKSESENLL 360
  361 IKISRFFKNG TWFDNKHLVN TMIEFLGDLT FREAYNRTGK ILNITVSPAS LFEQPRLLNN 420
  421 LTAPNVLIWS AVCASCSLPG IFPSSPLYEK DPKTGERKPW TGSSSVKFVD GSVDNDLPIS 480
  481 RLSEMFNVDH IIACQVNIHV FPFLKLSLSC VGGEIEDEFS ARLKQNLSSI YNFMANEAIH 540
  541 ILEIGSEMGI AKNALTKLRS VLSQQYSGDI TILPDMCMLF RIKELLSNPT KEFLLREITN 600
  601 GAKATWPKVS IIQNHCGQEF ALDKAISYIK GRMIVTSSLK TPFQFADSVI GLIKAPEQTS 660
  661 DESKNPENST LLTRTPTKGD NHISNVLDDN LLESESTNSL LLLRENASTY GRSPSGFRPR 720
  721 YSITSASLNP RHQRRKSDTI STSRRPAKSF SFSVASPTSR MLRQSSKING HPPPILQKKT 780
  781 SMGRLMFPMD AKTYDPESHE LIPHSASIET PAMVDKKLHF GRKSRYLRHM NKKWVSSSNI 840
  841 LYTDSDKEDH PTLRLISNFD SDAMIHSDLA GNFRRHSIDG RPPSQATKSS PFRSRPSSST 900
  901 QHKSTTSFTQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) TGL1 TGL3 TGL4 TGL5 YEH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TGL4 Huh WK, et al. (2003)
    View Data TGL4 and ERG6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] deduced N/A No confident structure predictions are available.
    2 View Details [113..259] MSA 1.039976 View MSA. No confident structure predictions are available.
    3 View Details [260..505] Pfam 56.455932 Patatin-like phospholipase No confident structure predictions are available.
    4 View Details [506..772] MSA 1.096972 View MSA. No confident structure predictions are available.
    5 View Details [773..910] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • phospholipase A2 activity
    		•  2.22630563405125 bayes_pls_golite062009
  • phospholipase activity
    		•  2.02363770793596 bayes_pls_golite062009
  • lipase activity
    		•  1.83391969295473 bayes_pls_golite062009
  • catalytic activity
    		•  1.681309422157 bayes_pls_golite062009
  • [acyl-carrier-protein] S-malonyltransferase activity
    		•  1.27314027329282 bayes_pls_golite062009
  • S-malonyltransferase activity
    		•  1.27314027329282 bayes_pls_golite062009
  • malonyltransferase activity
    		•  1.27314027329282 bayes_pls_golite062009
  • hydrolase activity
    		•  0.755660272658182 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  0.432469017757431 bayes_pls_golite062009
  • carboxylesterase activity
    		•  0.431665185524913 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.39017969987234 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  0.28475890150768 bayes_pls_golite062009
  • binding
    		•  0.112552746544258 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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