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Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. Catalysis of the hydrolysis of any ester bond. Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. Catalysis of the reaction: sphingomyelin + H2O = ceramide phosphate + choline. Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. Catalysis of the hydrolysis of a glycerophospholipid. Catalysis of the hydrolysis of a lipid or phospholipid.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: phospholipase activity
Acc: GO:0004620
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of a glycerophospholipid.
Proteins in PDR annotated with:
   This term: 47 [Search]
   Term or descendants: 373 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004620 - phospholipase activity (interactive image map)
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Created and Maintained by: Michael Riffle