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Protein Overview: ARX1

General Information:
Name(s) found: ARX1 / YDR101C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 593 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    nucleoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: ribosomal large subunit biogenesis [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALAISHEDT QILLKDKNIL QESVLNKYRT AGQIAQTALK YVTSLINDSY HSKTTQRQLT  60
   61 VPELCLLTDS FILTRLEQYY KNKVNERGIA IPTTIDIDQI SGGWCPEIDD TQNLLNWNKG 120
  121 KDSTFASSVT GTLRPGDLVK ITLGVHIDGY TSEVSHTMVI YPVDETKPIL QPTGPLLGGK 180
  181 ADAVAAAHIA METVVALLAC ALTPEKLPAS LGGTSSGITG QLIRTIVDTI ARSYNCGVVP 240
  241 GSRVRRIRRF LAGQNEGIVA EREYKGVVWT ESHQEADLLS NTDAKDLTVV DRGQSTPFTN 300
  301 VSAIPSDDFV VQSGEVYLID LKMASLEHCT KKGLVTLETV DSYTGKSHKA GELIARPGAY 360
  361 VRDFAQTHIL KLKTSRQLLT KIDKQGVYPF KLSHLSSNFP FVHENEEELQ SLKKDLKSFR 420
  421 LGMSEISNNY LCVESPIQIA RWVPWDHILK ATNPNGNLSY DATSTLTLPG HELPLPKLGV 480
  481 SAIKLKSLMN STKESISLPV ARECNTIVLC DSSVSTTDRP ELLRLTGGSK TCQPSWIHSQ 540
  541 HELNPQDSIV QGIFQLATLA KDKRFGLLLK ETQPMKQKSV ETSNGGVEET MKM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ALB1 ARX1 BUD20 CIC1 DBP10 DRS1 ERB1 HAS1 IPI1 IPI3 LSG1 MDN1 MRT4 NIP7 NMD3 NOC3 NOG1 NOG2 NOP15 NOP7 NSA1 NSA2 NUG1 REI1 RIX1 RIX7 RLP7 RPL25 RPL27A RPL28 RPL31A RPL36B RSA4 SDA1 SPB1 TIF6
    View Details Krogan NJ, et al. (2006) ALB1 ARX1 DBP9 GLE2 PSE1 RAD27 SLX9 THO1
    View Details Gavin AC, et al. (2006) ARX1 FPR4 MRT4 NIP7 NOG1 NOG2 NOP2 NSA2 NUG1 RPF2 SDA1 TIF6
    View Details Gavin AC, et al. (2002) ACT1 ADE3 ADH1 ARB1 ARO1 ARX1 BEM2 BMS1 BRX1 BUD20 CIC1 CLU1 CYR1 CYS4 DBP10 DBP2 DBP9 DCP2 DRS1 EBP2 EMP24 ERB1 ERP1 ERP2 ERV25 FKS1 FPR4 FUN12 GCN1 HAS1 HDA1 HER1 HHF1, HHF2 HIS3 HSC82 INP2 IPI1 IPI3 KAP123 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MLC1 MLC2 MRT4 MYO1 MYO2 MYO4 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PHB1 PRT1 PUF6 RAT1 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SHE2 SHE3 SHM1 SKI2 SNU13 SPB1 SPB4 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 VMA13 YEF3 YGL036W YPL009C YTM1
    View Details Ho Y, et al. (2002) AFG2 ALB1 ARX1 BUD20 DSS4 EHD3 FAA4 FYV4 HHF1, HHF2 HTA1 HTB1 HTB2 LHP1 MAM33 MNP1 MRPS16 NMD3 NOG1 NOP12 NOP13 NOP7 NSA2 NUG1 PRP43 PUF6 PWP1 RIX1 RSM24 RSM25 SEC4 YBL044W YPT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NAF1 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ARX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..355] PSI-BLAST 64.69897 Methionine aminopeptidase
    2 View Details [356..593] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle