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View Structure Prediction Details

Protein: DCP2
Organism: Saccharomyces cerevisiae
Length: 970 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DCP2.

Description E-value Query
Range
Subject
Range
DCP2 - Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure fr...
DCP2_YEAST - m7GpppN-mRNA hydrolase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DCP2 PE=1 SV=1
0.0 [1..970] [1..970]
DCP2_MOUSE - mRNA-decapping enzyme 2 OS=Mus musculus GN=Dcp2 PE=1 SV=1
2.0E-61 [14..238] [8..242]
gi|15451577 - gi|15451577|gb|AAK98701.1|AC069158_13 Putative ABC transporter [Oryza sativa]
4.0E-57 [24..245] [114..342]
DCP2_SCHPO - mRNA decapping complex subunit 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=dcp2 PE=1...
dcp2 - mRNA decapping complex subunit Dcp2
1.0E-54 [14..257] [7..255]
gi|19069226, gi|... - gi|19074584|ref|NP_586090.1| putative protein with Mut T domain (Nudix hydrolase family) [Encephalit...
gi|19074584 - gi|19074584|ref|NP_586090.1| putative protein with Mut T domain (Nudix hydrolase family) [Encephalit...
3.0E-52 [14..258] [2..232]
CE23761 - WBGene00003582 locus:dcap-2 status:Partially_confirmed SW:O62255 protein_id:CAB05206.2
3.0E-48 [14..200] [172..362]
gi|8163725, gi|8... - gi|8163725|gb|AAF73827.1| unknown [Streptococcus pneumoniae], gi|8163717|gb|AAF73820.1| unknown [Str...
3.0E-33 [107..294] [2..190]
gi|183576435, gi... - gi|183576435|gb|EDT96963.1| MutT/nudix family protein [Streptococcus pneumoniae CDC3059-06], gi|1684...
gi|15901504, gi|... - gi|15901504|ref|NP_346108.1| MutT/nudix family protein [Streptococcus pneumoniae TIGR4], gi|14973161...
gi|25389257 - pir||C95194 MutT/nudix family protein [imported] - Streptococcus pneumoniae (strain TIGR4)
1.0E-26 [67..227] [35..191]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPLRHALE NVTSVDRILE DLLVRFIINC PNEDLSSVER ELFHFEEASW FYTDFIKLMN  60
   61 PTLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [65-267]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLKIKSFAQL IIKLCPLVWK WDIRVDEALQ QFSKYKKSIP VRGAAIFNEN LSKILLVQGT  60
   61 ESDSWSFPRG KISKDENDID CCIREVKEEI GFDLTDYIDD NQFIERNIQG KNYKIFLISG 120
  121 VSEVFNFKPQ VRNEIDKIEW FDFKKISKTM YKSNIKYYLI NSMMRPLSMW LRHQRQIKNE 180
  181 DQLKSYAEEQ LKLLLGITKE EQI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1mut__
Description: Nucleoside triphosphate pyrophosphorylase (MutT)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [268-508]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPGRELLNML HTAVQANSNN NAVSNGQVPS SQELQHLKEQ SGEHNQQKDQ QSSFSSQQQP  60
   61 SIFPSLSEPF ANNKNVIPPT MPMANVFMSN PQLFATMNGQ PFAPFPFMLP LTNNSNSANP 120
  121 IPTPVPPNFN APPNPMAFGV PNMHNLSGPA VSQPFSLPPA PLPRDSGYSS SSPGQLLDIL 180
  181 NSKKPDSNVQ SSKKPKLKIL QRGTDLNSIK QNNNDETAHS NSQALLDLLK KPTSSQKIHA 240
  241 S

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.75
Match: 1deqA
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [509-587]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPDTSFLPND SVSGIQDAEY EDFESSSDEE VETARDERNS LNVDIGVNVM PSEKDSRRSQ  60
   61 KEKPRNDASK TNLNASAES

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [588-594]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSVEWGP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [821-903]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNSAKGLLNI LKKNDSTGYP RTEGGPSSEM STSMKRNDAT NNQELDKNST ELLNYLKPKP  60
   61 LNDGYENISN KDSSHELLNI LHG

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.74
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #6
Region A:
Residues: [595-667]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKSSPSTQSK QNSSVGMQNK YRQEIHIGDS DAYEVFESSS DEEDGKKLEE LEQTQDNSKL  60
   61 ISQDILKENN FQD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.74
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #7
Region A:
Residues: [668-750]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEVPHRDMPT ESNKSINETV GLSSTTNTVK KVPKVKILKR GETFASLAND KKAFDSSSNV  60
   61 SSSKDLLQML RNPISSTVSS NQQ

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.74
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #8
Region A:
Residues: [751-820]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPKSQHLSGD EEIMMMLKRN SVSKPQNSEE NASTSSINDA NASELLGMLK QKEKDITAPK  60
   61 QPYNVDSYSQ 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.74
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #9
Region A:
Residues: [904-970]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKNSSAFNNN VYATDGYSLA SDNNENSSNK LLNMLQNRSS AINEPNFDVR SNGTSGSNEL  60
   61 LSILHRK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle