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Protein Overview: MPP10

General Information:
Name(s) found: MPP10 / YJR002W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 593 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    small-subunit processome [IMPLink to PubMed article]
    nuclear outer membrane [TASLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: maturation of SSU-rRNA [IPILink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSELFGVLKS NAGRIILKDP SATSKDVKAY IDSVINTCKN GSITKKAELD EITVDGLDAN  60
   61 QVWWQVKLVL DSIDGDLIQG IQELKDVVTP SHNLSDGSTL NSSSGEESEL EEAESVFKEK 120
  121 QMLSADVSEI EEQSNDSLSE NDEEPSMDDE KTSAEAAREE FAEEKRISSG QDERHSSPDP 180
  181 YGINDKFFDL EKFNRDTLAA EDSNEASEGS EDEDIDYFQD MPSDDEEEEA IYYEDFFDKP 240
  241 TKEPVKKHSD VKDPKEDEEL DEEEHDSAMD KVKLDLFADE EDEPNAEGVG EASDKNLSSF 300
  301 EKQQIEIRKQ IEQLENEAVA EKKWSLKGEV KAKDRPEDAL LTEELEFDRT AKPVPVITSE 360
  361 VTESLEDMIR RRIQDSNFDD LQRRTLLDIT RKSQRPQFEL SDVKSSKSLA EIYEDDYTRA 420
  421 EDESALSEEL QKAHSEISEL YANLVYKLDV LSSVHFVPKP ASTSLEIRVE TPTISMEDAQ 480
  481 PLYMSNASSL APQEIYNVGK AEKDGEIRLK NGVAMSKEEL TREDKNRLRR ALKRKRSKAN 540
  541 LPNVNKRSKR NDVVDTLSKA KNITVINQKG EKKDVSGKTK KSRSGPDSTN IKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BFR2 BMS1 BUD21 DIM1 DIP2 ECM16 EMG1 ENP1 ENP2 IMP3 IMP4 KRE33 KRR1 MPP10 NAN1 NOC4 NOP1 NOP14 NOP56 NOP58 PNO1 PWP2 RCL1 ROK1 RPS13 RPS7A RRP12 RRP9 SAS10 SOF1 UTP10 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9
    View Details Krogan NJ, et al. (2006) JHD2 MPP10 SAS10 UGP1 UTP25
    View Details Gavin AC, et al. (2002) ADE4 ADH1 ASC1 BEM2 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HRR25 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PFS2 PNO1 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 RCL1 REF2 RIO2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SNF2 SNF5 SOF1 SRO9 SWI3 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YGR054W YOR059C YSH1
    View Details Qiu et al. (2008) FCF1 IMP3 IMP4 MPP10 RRP3 UTP15 UTP23

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #01 Alpha factor Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #28 Asynchronous Prep5-TiO2 Phosphopeptide Enrichment Keck JM, et al. (2011)
    View Run MLP2 #05 Alpha Factor Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #07 Alpha Factor Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] ab initio 8.65 No description for 1l8mA was found.
    2 View Details [79..157] ab initio 8.65 No description for 1l8mA was found.
    3 View Details [158..224] ab initio 8.65 No description for 1l8mA was found.
    4 View Details [225..302] ab initio 8.65 No description for 1l8mA was found.
    5 View Details [303..501] MSA 2.065996 View MSA. No confident structure predictions are available.
    6 View Details [502..593] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle