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Protein Overview: UTP18

General Information:
Name(s) found: UTP18 / YJL069C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 594 amino acids

    Gene Ontology:
    Cellular Component: nuclear outer membrane [IMPLink to PubMed article][IPILink to PubMed article]
    nucleolus [IDALink to PubMed articleLink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMATTAMNV SVPPPDEEEQ LLAKFVFGDT TDLQENLAKF NADFIFNEQE MDVEDQEDEG  60
   61 SESDNSEEDE AQNGELDHVN NDQLFFVDDG GNEDSQDKNE DTMDVDDEDD SSSDDYSEDS 120
  121 EEAAWIDSDD EKIKVPILVT NKTKKLRTSY NESKINGVHY INRLRSQFEK IYPRPKWVDD 180
  181 ESDSELDDEE DDEEEGSNNV INGDINALTK ILSTTYNYKD TLSNSKLLPP KKLDIVRLKD 240
  241 ANASHPSHSA IQSLSFHPSK PLLLTGGYDK TLRIYHIDGK TNHLVTSLHL VGSPIQTCTF 300
  301 YTSLSNQNQQ NIFTAGRRRY MHSWDLSLEN LTHSQTAKIE KFSRLYGHES TQRSFENFKV 360
  361 AHLQNSQTNS VHGIVLLQGN NGWINILHST SGLWLMGCKI EGVITDFCID YQPISRGKFR 420
  421 TILIAVNAYG EVWEFDLNKN GHVIRRWKDQ GGVGITKIQV GGGTTTTCPA LQISKIKQNR 480
  481 WLAVGSESGF VNLYDRNNAM TSSTPTPVAA LDQLTTTISN LQFSPDGQIL CMASRAVKDA 540
  541 LRLVHLPSCS VFSNWPTSGT PLGKVTSVAF SPSGGLLAVG NEQGKVRLWK LNHY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DIP2 IMP3 IMP4 MPP10 PWP2 RRP9 UTP10 UTP13 UTP15 UTP18 UTP21 UTP22 UTP4 UTP6 UTP7
    View Details Krogan NJ, et al. (2006) DIP2 HSV2 PWP2 UTP13 UTP18 UTP21 UTP6 YJL147C
    View Details Gavin AC, et al. (2006) CMS1 DIP2 MRD1 NAN1 NOP58 PNO1 PWP2 ROK1 RRP9 UTP10 UTP13 UTP15 UTP18 UTP21 UTP22 UTP4 UTP6 UTP7 UTP8 UTP9
    View Details Gavin AC, et al. (2002) ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PFS2 PNO1 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 RCL1 REF2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SOF1 SRO9 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YOR059C YSH1
    View Details Ho Y, et al. (2002) ARP10 CKA1 CKA2 CKB1 CKB2 DIP2 DIP5 ESL2 FET4 KRE33 LCP5 MUM2 NAN1 NOP1 NOP56 PGM2 PNO1 POR1 PRP40 PTC5 PWP2 RRP5 TFP1 UTP10 UTP11 UTP13 UTP14 UTP18 UTP21 UTP22 UTP30 UTP6 YHR020W
    View Details Qiu et al. (2008) DBP7 GAR1 MTR4 NSR1 NUG1 RNT1 UTP13 UTP18 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data UTP18 and SPC42 Unpublished Data
    View Data UTP18 Huh WK, et al. (2003)
    View Data UTP18 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..90] deduced N/A No confident structure predictions are available.
    2 View Details [91..231] MSA 2.981994 View MSA. No confident structure predictions are available.
    3 View Details [232..594] PSI-BLAST 73.0 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • snoRNA binding
    		•  3.51833501249106 bayes_pls_golite062009
    		• 3.41022148055944 bayes_pls_golite062009
  • RNA binding
    		•  3.0829625416797 bayes_pls_golite062009
  • binding
    		•  2.22722319261713 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.25687092973217 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.20712373307552 bayes_pls_golite062009
  • structural molecule activity
    		•  1.20572493724069 bayes_pls_golite062009
  • protein binding
    		•  1.11897341394404 bayes_pls_golite062009
  • DNA binding
    		•  0.711274653406079 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.523052412917759 bayes_pls_golite062009
  • ligase activity
    		•  0.280267687917718 bayes_pls_golite062009
  • transcription factor activity
    		•  0.243992994917491 bayes_pls_golite062009
  • mRNA binding
    		•  0.0519838181830878 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle