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View Structure Prediction Details

Protein: AHA1
Organism: Saccharomyces cerevisiae
Length: 350 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AHA1.

Description E-value Query
Range
Subject
Range
AHA1_YEAST - Hsp90 co-chaperone AHA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AHA1 PE=1 SV=1
AHA1 - Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is...
0.0 [1..350] [1..350]
YNY8_SCHPO - Uncharacterized protein C1711.08 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC1711....
SPBC1711.08 - chaperone activator Aha1
0.0 [5..350] [7..336]
AHSA1 - AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
0.0 [5..350] [21..337]
AHSA1_MOUSE - Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Mus musculus GN=Ahsa1 PE=1 SV=2
0.0 [5..350] [21..337]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-84 [58..350] [1..279]
gi|21593383, gi|... - gi|21593383|gb|AAM65332.1| unknown [Arabidopsis thaliana], gi|18399461|ref|NP_566410.1| Aha1 domain-...
4.0E-79 [5..347] [21..359]
gi|3850126 - gi|3850126|emb|CAA21927.1| conserved hypothetical protein [Candida albicans]
7.0E-48 [1..155] [1..147]

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Predicted Domain #1
Region A:
Residues: [1-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVNNPNNWH WVDKNCIGWA KEYFKQKLVG VEAGSVKDKK YAKIKSVSSI EGDCEVNQRK  60
   61 GKVISLFDLK ITVLIEGHVD SKDGSALPFE GSINVPEVAF DSEASSYQFD ISIFKETSEL 120
  121 SEAKPLIRSE LLPKLRQIFQ QFGKDLLATH GNDIQVPESQ VKSNYT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
chaperone binding 2.87169826684641 bayes_pls_golite062009
ATPase regulator activity 2.31076586548557 bayes_pls_golite062009
binding 2.05200237600398 bayes_pls_golite062009
ATPase activator activity 1.99816875782377 bayes_pls_golite062009
protein binding 1.12549021331477 bayes_pls_golite062009
heat shock protein binding 0.87871487226722 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [167-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGNQKSSFTE IKDSASKPKK NALPSSTSTS APVSSTNKVP QNGSGNSTSI YLEPTFNVPS  60
   61 SELYETFLDK QRILAWTRSA QFFNSGPKLE TKEKFELFGG NVISELVSCE KDKKLVFHWK 120
  121 LKDWSAPFNS TIEMTFHESQ EFHETKLQVK WTGIPVGEED RVRANFEEYY VRSIKLTFGF 180
  181 GAVL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.44038379867996 bayes_pls_golite062009
hydrolase activity 0.271155119882887 bayes_pls_golite062009
protein binding 0.186935278553638 bayes_pls_golite062009
catalytic activity 0.0116392906163881 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle