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Protein Overview: BCK1

General Information:
Name(s) found: BCK1 / YJL095W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1478 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: response to acid [IMPLink to PubMed article]
    endoplasmic reticulum unfolded protein response [IMPLink to PubMed article]
    intracellular protein kinase cascade [IMPLink to PubMed article]
    response to nutrient [IMPLink to PubMed article]
    protein amino acid phosphorylation [TASLink to PubMed article]
    Molecular Function: MAP kinase kinase kinase activity [IGILink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFLRKIAGT AHTHSRSDSN SSVKFGHQPT SSVASTKSSS KSPRATSRKS IYDDIRSQFP  60
   61 NLTPNSTSSQ FYESTPVIEQ SFNWTTDDHI SAGTLENPTS FTNSSYKNDN GPSSLSDSRK 120
  121 SSGGNSVNSL SFDKLILSWD PTDPDEWTMH RVTSWFKFHD FPESWILFFK KHQLFGHRFI 180
  181 KLLAYDNFAV YEKYLPQTKT ASYTRFQQLL KKTMTKNVTN SHIRQKSASK LKSSRSSSES 240
  241 IKSKLKNSKS QEDISNSRST SESALSPTKS GPSKTDEKNF LHSTSTHQKT KSASSLYRRS 300
  301 FISLRGSSSS NASSAKSPSN IKLSIPARPH SIIESNSTLT KSASPPASPS YPSIFRRHHK 360
  361 SSSSESSLLN SLFGSGIGEE APTKPNPQGH SLSSENLAKG KSKHYETNVS SPLKQSSLPT 420
  421 SDDKGNLWNK FKRKSQIGVP SPNTVAYVTS QETPSLKSNS STATLTVQTA DVNIPSPSSS 480
  481 PPPIPKTANR SLEVISTEDT PKISSTTASF KETYPDCINP DKTVPVPVNN QKYSVKNFLL 540
  541 DQKFYPLKKT GLNDSENKYI LVTKDNVSFV PLNLKSVAKL SSFKESALTK LGINHKNVTF 600
  601 HMTDFDCDIG AAIPDDTLEF LKKSLFLNTS GKIYIKDQMK LQQKPKPAPL TSENNVPLKS 660
  661 VKSKSSMRSG TSSLIASTDD VSIVTSSSDI TSFDEHASGS GRRYPQTPSY YYDRVSNTNP 720
  721 TEELNYWNIK EVLSHEENAP KMVFKTSPKL ELNLPDKGSK LNIPTPITEN ESKSSFQVLR 780
  781 KDEGTEIDFN HRRESPYTKP ELAPKREAPK PPANTSPQRT LSTSKQNKPI RLVRASTKIS 840
  841 RSKRSKPLPP QLLSSPIEAS SSSPDSLTSS YTPASTHVLI PQPYKGANDV MRRLKTDQDS 900
  901 TSTSPSLKMK QKVNRSNSTV STSNSIFYSP SPLLKRGNSK RVVSSTSAAD IFEENDITFA 960
  961 DAPPMFDSDD SDDDSSSSDD IIWSKKKTAP ETNNENKKDE KSDNSSTHSD EIFYDSQTQD1020
 1021 KMERKMTFRP SPEVVYQNLE KFFPRANLDK PITEGIASPT SPKSLDSLLS PKNVASSRTE1080
 1081 PSTPSRPVPP DSSYEFIQDG LNGKNKPLNQ AKTPKRTKTI RTIAHEASLA RKNSVKLKRQ1140
 1141 NTKMWGTRMV EVTENHMVSI NKAKNSKGEY KEFAWMKGEM IGKGSFGAVY LCLNVTTGEM1200
 1201 MAVKQVEVPK YSSQNEAILS TVEALRSEVS TLKDLDHLNI VQYLGFENKN NIYSLFLEYV1260
 1261 AGGSVGSLIR MYGRFDEPLI KHLTTQVLKG LAYLHSKGIL HRDMKADNLL LDQDGICKIS1320
 1321 DFGISRKSKD IYSNSDMTMR GTVFWMAPEM VDTKQGYSAK VDIWSLGCIV LEMFAGKRPW1380
 1381 SNLEVVAAMF KIGKSKSAPP IPEDTLPLIS QIGRNFLDAC FEINPEKRPT ANELLSHPFS1440
 1441 EVNETFNFKS TRLAKFIKSN DKLNSSKLRI TSQENKTE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BCK1 YIP5
    View Details Gavin AC, et al. (2002) ACE2 ALT2 BCK1 CDC11 DRE2 ECM30 ENP2 IML1 MNL1 MTR4 MYO2 RGC1 SEC3 UBP15 YBL044W YJR098C YNL313C
    View Details Ho Y, et al. (2002) AHA1 ARO1 ARP2 BCK1 BUL1 CHS1 CMP2 CPR6 DBP7 EGD2 FOL2 GAL7 GND1 IDH1 ILV5 IPP1 KIC1 KIN2 KOG1 KSP1 LHS1 LYS12 MKK2 MKT1 NPA3 OYE2 PDC6 PIL1 PMA1 PRB1 PRI2 PSY2 QCR2 RCN2 RGD1 RNQ1 RPN1 RPN6 RPN7 RPT3 RVB1 SIS1 SKG3 SLT2 SMK1 TIF1, TIF2 TPD3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BCK1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..653] deduced N/A No confident structure predictions are available.
    2 View Details [654..949] ORFEUS 10.04 No description for 1ldvA was found.
    3 View Details [950..1032] PSI-BLAST 15.0 pak1 autoregulatory domain
    4 View Details [1033..1129] deduced N/A No confident structure predictions are available.
    5 View Details [1130..1259] PSI-BLAST 486.9897 pak1
    6 View Details [1260..1478] PSI-BLAST 486.9897 pak1
    7 View Details [808..921] PSI-BLAST 10.30103 No description for 2nptB was found.
    8 View Details [922..1087] PSI-BLAST 16.221849 pak1 autoregulatory domain
    9 View Details [1088..1171] PSI-BLAST 34.30103 No description for 2ozoA was found.
    10 View Details [1172..1478] PSI-BLAST 117.0 Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.40869571527615 bayes_pls_golite062009
  • protein kinase activity
    		•  2.33375027480966 bayes_pls_golite062009
  • kinase activity
    		•  2.3070634049589 bayes_pls_golite062009
  • binding
    		•  2.24212855645397 bayes_pls_golite062009
  • protein binding
    		•  2.09596244214119 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.07643991042071 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.93849072962936 bayes_pls_golite062009
  • transferase activity
    		•  1.56694652741645 bayes_pls_golite062009
  • signal transducer activity
    		•  1.24594754122874 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.24594754122874 bayes_pls_golite062009
  • potassium channel regulator activity
    		•  1.20477942519661 bayes_pls_golite062009
  • phospholipase binding
    		•  0.746850275604721 bayes_pls_golite062009
  • kinase binding
    		•  0.452988418922855 bayes_pls_golite062009
  • protein kinase binding
    		•  0.438176837693626 bayes_pls_golite062009
    		• 0.31361705040754 bayes_pls_golite062009
  • hydrolase activity
    		•  0.297499761800095 bayes_pls_golite062009
  • channel regulator activity
    		•  0.295510833740311 bayes_pls_golite062009
  • catalytic activity
    		•  0.178906437366734 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle