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Protein Overview: RGD1

General Information:
Name(s) found: RGD1 / YBR260C [SGD]
Description(s) found:
Found 28 descriptions.
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  • GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 666 amino acids

    Gene Ontology:
    Cellular Component: cellular bud [IDALink to PubMed article]
    actin cortical patch [IDALink to PubMed article]
    Biological Process: response to acid [IMPLink to PubMed article]
    osmosensory signaling pathway [IGILink to PubMed article]
    Molecular Function: Rho GTPase activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEETAKKPAS ATVSAKSSHD GGTDDLAHLF STPEIKKVLN SDVAINALLS RLKQSLLTCE  60
   61 EFMKFIRKKY AFEEEHVQEL SKQYKHFFNI QGSTNSSLKK MIHEVLGFDG KMAQVKQSYI 120
  121 TALQKMYSEI SSLLLTMTKL RKSVKENSKR LEKDVSDAIH SAEKAQSRYN SLCQDWDKLR 180
  181 MTDPTKTKLT LRGSKTTKEQ EEELLRKIDN ADLEYKQKVD HSNSLRNTFI TKERPRIVQE 240
  241 LKDLILEIDT AMTIQLQKYT IWTENLVLNT GVTISPLDST KSMKSFAGSV SNERDLYSFL 300
  301 NKYNQTGKHS LLINKNLIPV SYKKHPSMNH GQKNKSPPKF AVDPSRNSIP KRMISTHNES 360
  361 PFLSSSSNTA AVPNANLNSA TPSLNTNKQL PPTMASSISS TSNAAGAMSP SSSIVTSDTT 420
  421 SSITKTLDPG NNSPQIPEEL INSLDSDRPI SHIQTNNNMP PGVQKNFKTF GVPLESLIEF 480
  481 EQDMVPAIVR QCIYVIDKFG LDQEGIYRKS ANVLDVSKLK EEIDKDPANI SMILPSKPHS 540
  541 DSDIYLVGSL LKTFFASLPD SVLPKALSSE IKVCLQIEDP TTRKNFMHGL IYNLPDAQYW 600
  601 TLRALVFHLK RVLAHEAQNR MNLRALCIIW GPTIAPANPD DANDVNFQIM AMEVLLEVSD 660
  661 QAFEPE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FYV8 RGD1
    View Details Krogan NJ, et al. (2006) FYV8 RGD1
    View Details Ho Y, et al. (2002) ARP2 BCK1 BUL1 CDC12 DOG1 DOG2 GUS1 IDH1 IMD4 LYS12 MET6 MKK2 MSK1 NPA3 PRB1 PYC1 RGD1 RNQ1 RPN1 RPN7 RVB1 SEC53 TMA19 VMA22
    View Details Qiu et al. (2008) LRG1 RGD1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RGD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..435] PSI-BLAST 14.39794 Heavy meromyosin subfragment
    2 View Details [436..559] PSI-BLAST 166.70927 p50 RhoGAP domain
    3 View Details [560..666] PSI-BLAST 166.70927 p50 RhoGAP domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.43584893484993 bayes_pls_golite062009
  • protein binding
    		•  1.87308005875135 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.48820833936343 bayes_pls_golite062009
  • signal transducer activity
    		•  0.546501086239797 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.546501086239797 bayes_pls_golite062009
  • GTPase binding
    		•  0.50066793947946 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.459881864914566 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.456472132383968 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.180886944097381 bayes_pls_golite062009
  • small GTPase binding
    		•  0.0531578648468707 bayes_pls_golite062009
    2
    Term Confidence Notes
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  3.29568423512865 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • binding
    		•  2.36195429973813 bayes_pls_golite062009
  • actin binding
    		•  2.22794146985308 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.05040620031468 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.70891877343852 bayes_pls_golite062009
  • signal transducer activity
    		•  0.648419213388211 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.648419213388211 bayes_pls_golite062009
  • actin filament binding
    		•  0.613502134123252 bayes_pls_golite062009
  • motor activity
    		•  0.55239878540339 bayes_pls_golite062009
  • diacylglycerol binding
    		•  0.515403424540209 bayes_pls_golite062009
  • tubulin binding
    		•  0.477476507404761 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.36751853312336 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.348246993470003 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle